H. Frasure

The association between quality of life and overall survival in ovarian cancer patients during adjuvant chemotherapy: A Gynecologic Oncology Group study.

5075 Background: To explore the association between baseline quality-of-life (QOL) domain scores and overall survival (OS) in ovarian cancer patients receiving adjuvant chemotherapy. Methods: Patients with optimal stage III ovarian cancer on Gynecologic Oncology Group protocol #172 completed the Functional Assessment of Cancer Therapy-Generic (FACT-G) and were then randomly assigned to either intravenous (IV) or intraperitoneal (IP) chemotherapy. The FACT scale includes physical, functional, social, and emotional well- being domains (PWB, FWB, SWB, EWB). Patients who rated their lack of energy as ‘quite a bit or very much were compared with those who reported higher energy levels. Results: After adjusting for patient age, treatment assignment, and the presence of gross disease, only the PWB subscale was significantly associated with OS. Patients who reported baseline PWB scores in the lowest quantile (PWB score < 15 points) had decreased OS (HR: 1.81; 95% CI: 1.2∼f2.72; p = 0.005) relative to those wh...