H. Gokmen Ozel

PP266-SUN: Determining the Effects of Dietary Proteins and Fats on Blood Glucose in Type 1 Diabetes

Rationale: The study investigated the effects of dietary proteins and fats on blood glucose and the effects of fatprotein (CFP) counting in addition to carbohydrate (CARB) counting for calculating prandial insulin dosage on blood glucose profile in subjects with type 1 diabetes (T1D) who are under multiple dose insulin treatment. Methods: Thirty subjects with T1D, aged 16 18 years, were given 4 different breakfast meals being standardized meal (SM-insulin dose based on CARB counting), meal with high protein (MHP-CARB counting), meal with high protein-high fat (MHPF-a-CARB counting) and meal with high protein-high fat (MHPF-b-CARB and CFP counting) on different days. On the 0, 30, 60, 90, 120, 150, 180, 210 and 240 minutes of meals consumption capillary blood sample was examined. Results: The blood glucose levels of 0 90min did not change after different meals consumption (p > 0.05), blood glucose levels were higher after MHPF-b consumption compared to MHPF-a consumption in measurements during 120 240min (p < 0.05). There were no difference between meals in early (0 120min) postprandial glucose response (p = 0.405). There were no difference between SM, MHP and MHPF-a in late (120 240min) response while response after MHPF-b was significantly lower than response after SM, MHP and MHPF-a consumption (p = 0.032). There were no difference in relative glycaemic index (RGI) on 0 120min between meals while RGI of MHPF-a on 120 240min (118.92±44.62) was significantly higher than of SM (100.00±0.00) and MHPF-b (95.03±39.01) and RGI of MHPF-b was lower than MHP (109.77±37.42) (p = 0.046). RGI of MHPF-a (110.47±25.95) on 0 240min was found to be significantly higher than of SM (100.00±0.00) and MHPF-b (94.98±24.38) (p = 0.046). Conclusion: It was concluded in the study that meal-related insulin dosing based on carbohydrate plus fat/protein counting has given positive results in postprandial glycaemic profile in subjects with T1D.