H. L. De Winter

Properties of oligonucleotides with six membered carbohydrate mimics and a 1,4-relationship between the base moiety and the hydroxymethyl group

Abstract The properties of oligonucleotides with a six-membered carbohydrate mimic in the backbone structure and a 1,4-relationship between the base moiety and the hydroxymethyl group are summarized. The different six-membered rings that were studied are: 1,5-anhydro-2,3-dideoxy-D-arabino-hexitol, 1,5-anhydro-2-deoxy-D-mannitol, 1,5-anhydro-2-deoxy-D-altritol and 3-hydroxy-4-hydroxymethyl-cyclohexane.

(+)-(2R-cis)-Dimethyl(10-bromo-2,3,3a,8-tetrahydrodibenz[c,f]isoxazolo[2,3-a]azepin-2-ylmethyl)amine

The title compound, C 19 H 21 BrN 2 O, is a central active serotonin 5-HT 2c antagonist with some H 1 affinity. The (6,7,6)-tricyclic moiety is asymmetrically folded with a dihedral angle of 124.3 (1)° between the aromatic planes. The fused tetrahydroisoxazole ring adopts a conformation halfway between that of a twist and an envelope.