H. Marrak

Acebutolol-induced subacute cutaneous lupus erythematosus.

Beta-blocking medications are rarely associated with drug-induced lupus erythematosus syndrome and have never been incriminated as a cause of subacute lupus erythematosus (SCLE). We present herein the first case of SCLE induced by acebutolol. A 57-year-old woman presented with a 1-month history of a cutaneous eruption of the photoexposed areas. One month ago, the patient had started a treatment with oral acebutolol to cure a hypertension of 1-year evolution. Physical examination revealed erythematous scaly annular plaques, involving the face, arms and trunk. Immunologic serology findings revealed a positive titer of antinuclear antibodies up to 1/1,280 with positivity of antihistone and Ro/SSA antibodies. Acebutolol was stopped, and the lesions cleared completely 4 months later. Literature data, along with our case, suggest a link between acebutolol therapy and the onset of a lupus syndrome. Although this is the first report of acebutolol-induced SCLE, we should be aware of this occurrence, and avoidance of acebutolol is recommended in patients with stigmata of lupus erythematosus

Hémangioendothéliome épithélioïde cutané

Resume Introduction L’hemangioendotheliome epithelioide est une tumeur des tissus mous prenant naissance a partir de l’endothelium vasculaire. Elle est consideree comme une tumeur de bas grade de malignite. La localisation a la peau est tres rare et fait souvent partie d’une atteinte multisystemique. Observation Une femme de 34 ans, consultait pour un nodule cutane erythemato-violace, douloureux, siegeant a l’avant-bras droit et evoluant depuis 6 mois. Une echographie abdominale avait ete pratiquee 1 mois avant l’apparition du nodule cutane, du fait de douleurs epigastriques et etait normale. Les examens histologiques et immunohistochimiques cutanes permettaient de poser le diagnostic d’hemangioendotheliome epithelioide. Le bilan d’extension, comprenant des examens radiologiques, echographiques, un scanner thoraco-abdominal et une imagerie par resonance magnetique, revelait la presence de nodules hepatiques. Le traitement consistait en une exerese large et complete de la tumeur. Apres un an d’evolution, aucune recidive locale n’etait observee et les localisations hepatiques etaient stables. Discussion L’hemangioendotheliome epithelioide appartient au groupe des tumeurs vasculaires epithelioides ayant en commun un aspect morphologique epithelioide des cellules tumorales endotheliales. La localisation a la peau est rare et a notre connaissance, seulement 20 cas d’hemangioendotheliome epithelioide avec atteinte cutanee ont ete rapportes dans la litterature. L’hemangioendotheliome epithelioide cutane peut rester isole ou rentrer dans le cadre d’une maladie multifocale avec des atteintes viscerales associees. Ainsi, la decouverte de lesions cutanees impose la pratique d’un bilan d’extension a la recherche de localisations profondes. L’hemangioendotheliome epithelioide etant considere comme une tumeur de bas grade de malignite, l’integrite du foie chez cette malade, observee un mois avant l’apparition de la maladie, est en faveur d’une maladie multicentrique plutot que de localisations metastatiques hepatiques d’une tumeur cutanee primitive.

Tongue hyperpigmentation during PEG-interferon-alfa/ribavirin therapy in a non-Caucasian patient with chronic hepatitis C: a case report and review of the literature

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Unilateral upper limb skin sarcoid reaction after homolateral mastectomy for breast cancer

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