H. Regaieg

Fatal anaphylactic reaction to intravenous infusion of Ondansetron: a report of two cases

Ondansetron is a selective 5 hydroxy-tryptamine 3 (5-HT3) receptor antagonist widely used as an effective antiemetic drug especially for the prevention of chemotherapy-induced nausea and vomiting [1]. The efficacy of ondansetron has been reported in several studies and it is reported to be a well-tolerated drug [2]. The most common side effects reported to ondansetron are headaches, diarrhea, constipation, fever and dizziness [3-5]. Anaphylactic reaction to ondansetron is rarely reported [6,7]. Abstract

Leucémie myélomonocytaire juvénile : à propos de trois cas

Juvenile myelomonocytic leukemia (JMML), previously known as juvenile chronic myeloid leukemia (JCML), is a rare, myelodysplastic-myeloproliferative disease typically presenting in early childhood. This disorder is difficult to distinguish from other myeloproliferative syndromes such as chronic myeloid leukemia (CML) because of the similarities in their clinical and bone marrow findings. However, because of its unique biological characteristics such as absolute monocytosis with dysplasia, absence of Philadelphia chromosome or BCR-ABL fusion protein, hypergammaglobulinemia, and raised fetal hemoglobin level, this disorder does not satisfy the criteria for inclusion in the CML or chronic myelomonocytic leukemia (CMML) group, as seen in adult patients. We describe three cases of JMML, who had very similar clinical and laboratory findings.

Primary Testicular Lymphoma: A Study of 11 Cases

Primary testicular lymphoma(PTL) is an uncommon extranodal presentation constituting 1% of all NHL and 5% of all testicular neoplasm. The objective of our study was to identify the presenting signs and symptoms, treatment and outcome of patients with testicular lymphoma diagnosed atthe Hematology department of Farhat Hached University Hospital from 1997 to 2007 and to perform bibliography review about this pathology. Eleven cases were identified; the median age was 61 years (range:31-83).All patients presented with testicular and s crotal swelling or mass.B symptoms (recurrent fever of>38∫C temperature, night sweets and unexplained weight loss of>10% of the body weight within six months prior to diagnosis) were present in 6 patients. According to the