H. Sorg

Stammzellen aus dem Fettgewebe

While stem cells derived from the bone marrow are well-known in clinical medicine, fatty tissue as a source of mesenchymal stem cells is still the subject of recent research. However, adipose-derived stem cells (ASC) are not only harvested less invasively, i.e. via minimally invasive liposuction, but also yield higher numbers of multipotent stem cells.Due to cell-cell interactions and also because of the very favorable secretion profile of growth factors and cytokines ASCs displayed an extraordinary regenerative potential in recent preclinical and clinical applications and achieved a significantly better healing in ischemic muscle, heart, and brain insults and in impaired wound healing. ASCs enhanced regeneration in skeletal tissues such as cartilage or bone. They also revealed immunomodulatory effects and improved the clinical status in immunological diseases.In conclusion ASCs are comparable to bone marrow-derived stem cells concerning possible applications in clinical medicine.

[Stem cells from fatty tissue : A new resource for regenerative medicine?].

While stem cells derived from the bone marrow are well-known in clinical medicine, fatty tissue as a source of mesenchymal stem cells is still the subject of recent research. However, adipose-derived stem cells (ASC) are not only harvested less invasively, i.e. via minimally invasive liposuction, but also yield higher numbers of multipotent stem cells.Due to cell-cell interactions and also because of the very favorable secretion profile of growth factors and cytokines ASCs displayed an extraordinary regenerative potential in recent preclinical and clinical applications and achieved a significantly better healing in ischemic muscle, heart, and brain insults and in impaired wound healing. ASCs enhanced regeneration in skeletal tissues such as cartilage or bone. They also revealed immunomodulatory effects and improved the clinical status in immunological diseases.In conclusion ASCs are comparable to bone marrow-derived stem cells concerning possible applications in clinical medicine.

Primärversorgung von Sehnenverletzungen der Hand

ZusammenfassungSehnenverletzungen der Hand sind häufig und stellen hohe Ansprüche an die chirurgische Versorgung. Eine genaue Kenntnis der Anatomie der Streck- und Beugesehnen im Bereich der Hand ist Voraussetzung, um eine detaillierte klinische Untersuchung durchführen und die richtige Diagnose stellen zu können. Abhängig von der vorliegenden Verletzung kommen verschiedene konservative oder operative Therapieoptionen in Betracht. Im Gesamtkonzept der Versorgung von Sehnenverletzungen der Hand spielt die Nachbehandlung eine wichtige Rolle, um ein optimales funktionelles Ergebnis zu erzielen. Es ist jedoch zu beachten, dass Ausmaß, Mechanismus und exakte anatomische Lokalisation der Verletzung sowie Begleitverletzungen ebenso die Operationsergebnisse beeinflussen wie die Mitarbeit des einzelnen Patienten in der Nachbehandlung.AbstractTendon injuries of the hand are common and their treatment is surgically challenging. Precise knowledge of the anatomy of the extensor and flexor tendons in the hand is necessary to be able to perform a detailed clinical examination and to estimate adequately the extent of injury. Depending on the injury pattern, various conservative and surgical treatment options must be considered. Concerning the overall concept of the supply of tendon injuries of the hand, follow-up treatment is crucial to achieve an optimal functional outcome. It should be noted, however, that the results are influenced by the following: extent of the injury, mechanism, exact anatomical location, associated injuries, and finally the participation of the patient in the follow-up treatment.Tendon injuries of the hand are common and their treatment is surgically challenging. Precise knowledge of the anatomy of the extensor and flexor tendons in the hand is necessary to be able to perform a detailed clinical examination and to estimate adequately the extent of injury. Depending on the injury pattern, various conservative and surgical treatment options must be considered. Concerning the overall concept of the supply of tendon injuries of the hand, follow-up treatment is crucial to achieve an optimal functional outcome. It should be noted, however, that the results are influenced by the following: extent of the injury, mechanism, exact anatomical location, associated injuries, and finally the participation of the patient in the follow-up treatment.

Die Rolle von Erythropoietin bei der Verbesserung der Wundheilung

ZusammenfassungPleiotrope Substanzen sind durch ihr ausgesprochen vielfältiges und komplexes Wirkspektrum charakterisiert und dies macht sie für die Therapie von Wunden attraktiv. Neben seinem bekannten Effekt der Steigerung der Hämatopoese konnte das Glykoproteinhormon Erythropoietin (EPO) in diversen anderen Organen eine deutliche Gewebeprotektion aufzeigen. Der Einsatz von EPO im Rahmen von Regenerationsprozessen der Haut basiert hier wahrscheinlich im Wesentlichen auf seiner zytoprotektiven, proangiogenen, antiapoptotischen sowie antiinflammatorischen Wirksamkeit. Hier kann EPO durch eine niedrigdosierte bzw. einmalige Applikation die strukturelle und koordinierte Interaktion verschiendener Zelltypen untereinander stimulieren. Diese Übersichtsarbeit soll die Vor- und Nachteile einer EPO-Gabe im Rahmen verschiedener Heilungs- und Regenerationsvorgänge der Haut aus der experimentellen Forschung beleuchten und mögliche klinische Anwendungen diskutieren.AbstractPleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.Pleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.

Primärversorgung von Sehnenverletzungen der Hand@@@Primary treatment of tendon injuries of the hand

ZusammenfassungSehnenverletzungen der Hand sind häufig und stellen hohe Ansprüche an die chirurgische Versorgung. Eine genaue Kenntnis der Anatomie der Streck- und Beugesehnen im Bereich der Hand ist Voraussetzung, um eine detaillierte klinische Untersuchung durchführen und die richtige Diagnose stellen zu können. Abhängig von der vorliegenden Verletzung kommen verschiedene konservative oder operative Therapieoptionen in Betracht. Im Gesamtkonzept der Versorgung von Sehnenverletzungen der Hand spielt die Nachbehandlung eine wichtige Rolle, um ein optimales funktionelles Ergebnis zu erzielen. Es ist jedoch zu beachten, dass Ausmaß, Mechanismus und exakte anatomische Lokalisation der Verletzung sowie Begleitverletzungen ebenso die Operationsergebnisse beeinflussen wie die Mitarbeit des einzelnen Patienten in der Nachbehandlung.AbstractTendon injuries of the hand are common and their treatment is surgically challenging. Precise knowledge of the anatomy of the extensor and flexor tendons in the hand is necessary to be able to perform a detailed clinical examination and to estimate adequately the extent of injury. Depending on the injury pattern, various conservative and surgical treatment options must be considered. Concerning the overall concept of the supply of tendon injuries of the hand, follow-up treatment is crucial to achieve an optimal functional outcome. It should be noted, however, that the results are influenced by the following: extent of the injury, mechanism, exact anatomical location, associated injuries, and finally the participation of the patient in the follow-up treatment.Tendon injuries of the hand are common and their treatment is surgically challenging. Precise knowledge of the anatomy of the extensor and flexor tendons in the hand is necessary to be able to perform a detailed clinical examination and to estimate adequately the extent of injury. Depending on the injury pattern, various conservative and surgical treatment options must be considered. Concerning the overall concept of the supply of tendon injuries of the hand, follow-up treatment is crucial to achieve an optimal functional outcome. It should be noted, however, that the results are influenced by the following: extent of the injury, mechanism, exact anatomical location, associated injuries, and finally the participation of the patient in the follow-up treatment.

The role of erythropoietin in improvement of wound healing

ZusammenfassungPleiotrope Substanzen sind durch ihr ausgesprochen vielfältiges und komplexes Wirkspektrum charakterisiert und dies macht sie für die Therapie von Wunden attraktiv. Neben seinem bekannten Effekt der Steigerung der Hämatopoese konnte das Glykoproteinhormon Erythropoietin (EPO) in diversen anderen Organen eine deutliche Gewebeprotektion aufzeigen. Der Einsatz von EPO im Rahmen von Regenerationsprozessen der Haut basiert hier wahrscheinlich im Wesentlichen auf seiner zytoprotektiven, proangiogenen, antiapoptotischen sowie antiinflammatorischen Wirksamkeit. Hier kann EPO durch eine niedrigdosierte bzw. einmalige Applikation die strukturelle und koordinierte Interaktion verschiendener Zelltypen untereinander stimulieren. Diese Übersichtsarbeit soll die Vor- und Nachteile einer EPO-Gabe im Rahmen verschiedener Heilungs- und Regenerationsvorgänge der Haut aus der experimentellen Forschung beleuchten und mögliche klinische Anwendungen diskutieren.AbstractPleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.Pleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.

Die Rolle von Erythropoietin bei der Verbesserung der Wundheilung@@@The role of erythropoietin in improvement of wound healing

ZusammenfassungPleiotrope Substanzen sind durch ihr ausgesprochen vielfältiges und komplexes Wirkspektrum charakterisiert und dies macht sie für die Therapie von Wunden attraktiv. Neben seinem bekannten Effekt der Steigerung der Hämatopoese konnte das Glykoproteinhormon Erythropoietin (EPO) in diversen anderen Organen eine deutliche Gewebeprotektion aufzeigen. Der Einsatz von EPO im Rahmen von Regenerationsprozessen der Haut basiert hier wahrscheinlich im Wesentlichen auf seiner zytoprotektiven, proangiogenen, antiapoptotischen sowie antiinflammatorischen Wirksamkeit. Hier kann EPO durch eine niedrigdosierte bzw. einmalige Applikation die strukturelle und koordinierte Interaktion verschiendener Zelltypen untereinander stimulieren. Diese Übersichtsarbeit soll die Vor- und Nachteile einer EPO-Gabe im Rahmen verschiedener Heilungs- und Regenerationsvorgänge der Haut aus der experimentellen Forschung beleuchten und mögliche klinische Anwendungen diskutieren.AbstractPleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.Pleiotropic substances are characterized by their versatile and complex range of actions which makes them potential new active agents for the therapy of wounds. Besides its known effect to increase red blood cell production, the glycoprotein hormone erythropoietin (EPO) has been found to demonstrate a tissue protective effect in several other organs. The administration of EPO during skin wound healing is most likely essentially based on its cytopotective, proangiogenic, antiapoptotic and antiinflammatory effects. Herein EPO stimulates a coordinated interaction of different types of cells at a low or only a single dose. This review article aims to present the advantages and disadvantages of EPO administration in different experimental models to study the healing and regeneration processes of the skin and discusses possible clinical applications.

Stammzellen aus dem Fettgewebe@@@Stem cells from fatty tissue: Eine neue Ressource für die regenerative Medizin?@@@A new resource for regenerative medicine?

While stem cells derived from the bone marrow are well-known in clinical medicine, fatty tissue as a source of mesenchymal stem cells is still the subject of recent research. However, adipose-derived stem cells (ASC) are not only harvested less invasively, i.e. via minimally invasive liposuction, but also yield higher numbers of multipotent stem cells.Due to cell-cell interactions and also because of the very favorable secretion profile of growth factors and cytokines ASCs displayed an extraordinary regenerative potential in recent preclinical and clinical applications and achieved a significantly better healing in ischemic muscle, heart, and brain insults and in impaired wound healing. ASCs enhanced regeneration in skeletal tissues such as cartilage or bone. They also revealed immunomodulatory effects and improved the clinical status in immunological diseases.In conclusion ASCs are comparable to bone marrow-derived stem cells concerning possible applications in clinical medicine.