H.Th.M. Folgering

Effects of inhaled beclomethasone dipropionate on beta2-receptor function in the airways and adrenal responsiveness in bronchial asthma

SummarySixteen patients suffering from bronchial astham, with or without chronic bronchitits, sufficiently severe to be treated with inhaled corticosteroids, were studied in a single-blind trial (blind observer) of beclomethasone dipropionate (BDP) given in three randomized dosage regimens: 500, 1000 and 2000 µg per day, each for 4 weeks. The β2-adrenergic agoinst response curve showed a dose-dependent increase in FEV1 which was not affected by different doses of BDP. A small but significant reduction in basal cortisol levels was observed after BDP 500 µg/day. There was no significant difference between the various doses of BDP in reducting cortisol level and stimulation with tetracosactide remained unchanged. The study showed a gradual, dose-dependent improvement in lung function, statistically significant for morning peak expiratory flow rate at BDP 2000 µg/day. Dyspnoea score and β2-agonist use decreased, reflecting the anti-asthmatic effects. An increase in total leukocyte count was observed, together with a decrease in the eosinophil count. Oral candidiasis was seen in 2 out of 16 patients. It is concluded that the clinical anti-asthmatic effects of corticosteroid treatment by inhalation are not due to modulation of β2-receptor function in the airways.

Ventilatory response to CO2 at rest and during positive and negative work in normoxia and hyperoxia.

SummaryVentilation versus alveolar

Capnostat and oxystat. Electronic devices to automatically maintain the end-tidal\(P_{CO_2 } \) and\(P_{O_2 } \) of a subject connected to a closed respiratory circuit at adjustable levels

P_{CO_2 }

Ventilatory effects of beta1-receptor-selective blockade with bisoprolol and metoprolol in asthmatic patients

relationships were determined by the steady-state method in 6 normal male subjects at rest and during positive and negative work at one load in both normoxic and hyperoxic condition. In 5 subjects the slopes of the

Oscillatory respiratory impedance and lung tissue compliance

\dot V_E - P_{A_{CO_2 } }

Target-flow inspiratory muscle training at home and during pulmonary rehabilitation in COPD patients with a ventilatory limitation during exercise.

lines during positive and negative work increased in normoxia as compared with rest. This effect was less evident in hyperoxia. It was also found that the slopes of the