H. Walter

The Y-Specific SSLP of the Locus DYS19 in Four Different European Samples

The Y-Specific Simple Sequence Length Polymorphism (SSLP) of the locus DYS19 was investigated in two Slovakian samples--Bratislava and Medzev--and in two German samples--Bremen and Hannover. The allele frequencies show a significant difference between the Slovakian and German samples.

GM and KM allotypes in nine population samples of Sicily

Serum samples of 864 unrelated healthy male and female individuals belonging to nine provinces of Sicily were types for Glm (1,2,3,17), G3m (5,10,11,13,14,15,16,21), and KM (1). With the exception of the Trapani sample these samples are characterized by the presence of five GM haplotypes: GM*1,17;21,26; GM*1,2,17;21,26; GM*1,3;5,10,11,13,14,26; GM*3;5,10,13,14,26; and GM*1,17;10,11,13,15,16. The interpopulation variability in the distribution of these haplotypes is considerable, which is especially due to haplotypes GM*1,3;5,10,11,13,14,26, and GM*3;5,10,13,14,26. However, no clear-cut clustering of the samples according to historical or geographical facts could be shown. Comparisons with other Italian populations reveal the considerable genetic difference of the Sicilians, which is in particular caused by the presence of the haplotypes GM*1,3;5,10,11,13,14,26, and GM*1,17;10,11,13,15,16. These haplotypes are quite uncommon in Europeans and may reflect gene flow from the Middle East. The KM phenotype and allele frequencies also show a considerable interpopulation variability among the nine Sicilian samples, but as for GM no distinction between eastern and western provinces of Sicily is present.

Genetic studies in four tribal populations of the Surat District, Gujarat (India)

Four tribal populations (Chaudhuri, Vasava, Kotwalia and Gamit) of the Surat District in Gujarat (India) have been investigated for the distribution of 22 polymorphic systems of the blood. The main results of this study are as follows: The allele frequencies show considerable heterogeneity among these populations. From the genetic structure analysis it is seen that only a small fraction of the total gene diversity accounts for genetic differences among them, and the major portion of it is due to genetic variation within them. Analysis of genetic distance according to Nei (1972) reveals that the Vasava and Kotwalia show a rather close genetic relationship, while the Chaudhuri and Gamit differ from both the Vasava and Kotwalia.

Red cell polymorphisms in Sardinia

Acid phosphatase (ACP1), esterase D (ESD) and phosphoglucomutase 1 (PGM1) polymorphisms have been studied in Sardinia and the following gene frequencies have been found: ACP1*A = 0.235, ACP1*B = 0.684 and ACP1*C = 0.081; ESD*2 = 0.118 and PGM1*2 = 0.233. These findings confirm the genetic uniqueness of Sardinians compared to the other Italian and European populations.

Red-Cell Enzyme Polymorphisms in the Reggio Calabria Province (Italy)

Acid phosphatase (ACP1), adenosine deaminase (ADA), esterase D (ESD), glyoxalase 1 (GLO1), phosphogluconate dehydrogenase (PGD) and phosphoglucomutase 1 and 2 (PGM1 and PGM2) polymorphisms have been studied in the Reggio Calabria province (Southern Italy). The ACP1*A allele and ADA, GLO1, PGD and PGM1 systems have frequencies similar to those reported for Sicily and Southern Italy.

On the Variability of Gc Subtypes in Italy

909 individuals from different places of Italy were analyzed for the distribution of Gc subtypes. The observed heterogeneity in the distribution of the allele frequencies was found to be statistically significant. Comparing our results with those reported by other authors it is seen that within Italy a considerable regional variation in the frequencies of the Gc subtype alleles is present. However, there are no indications for any particular distribution patterns or gradients. In one of our samples (Bari district), one case of Gc 1S-1C3 was found.

Genetic Heterogeneity in Italy

The studies carried out by several Authors on the distribution of genetic markers in Italy have shown a more or less genetic heterogeneity of the Italian population. At present, however, a detailed regional analysis of it is still standing out.