H. Wong

Two synthetic approaches to rebeccamycin

Abstract Two synthetic approaches to a new indolocarbazole antitumor antibiotic, rebeccamycin, were developed. The absolute configuration of rebeccamycin was determined by a total synthesis.

Total synthesis of (±) podophyllotoxin

Abstract A straightforward approach to podophyllotoxin was developed using silyl enol ether 5 .

A new and mild method for the reduction of secondary amides to carbinolamine ethers and imines: a conversion of oxotomaymycin to tomaymycin

Abstract A new and mild method for reducing 2° amides to carbinolamine ethers and imines and its use in the synthesis of pyrrolo[1,4]benzodiazepine antibiotics is reported.

Stereochemical studies on esperamicins: Determination of the absolute configuration of hydroxyamino sugar fragment.

Abstract The β-D-gluco-hexopyranose configuration has been assigned for the hydroxyamino sugar fragment of esperamicin A 1 . This determination concluded our study on the absolute configuration of the carbohydrate portion of esperamicins.

Stereochemical studies on esperamicins: Determination of the absolute configuration of isopropylamino sugar moiety

The absolute stereochmistry of the isopropylamino sugar moiety of esperamicin A1 was determined as the α-L-threo-pentopyranosyl by comparing the CD spectra of derivatized methanolysis product 4 with those of two synthesized antipodal glycosides 9 and 11.

New chemistry of mitomycin C

Abstract Novel and significant analogues of mitomycin C were prepared based on new chemistry utilizing mitomycin C in its anion form.