Ha Young Chung
Kyung Hee University
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Featured researches published by Ha Young Chung.
SpringerPlus | 2015
Ho Seob Soh; Ha Young Chung; Hyun Ho Lee; Hemavathi Ajjappala; Kyoungok Jang; Jong-Hwa Park; Joon-Soo Sim; Gee Young Lee; Hyun Ju Lee; Young Hee Han; Jae Wook Lim; Inchan Choi; In-Sik Chung; Bum-Soo Hahn
We expressed the heat-labile enterotoxin B (LTB) subunit from enterotoxigenic Escherichia coli and the cholera toxin B (CTB) subunit from Vibrio cholerae under the control of the rice (Oryza sativa) globulin (Glb) promoter. Binding of recombinant LTB and CTB proteins was confirmed based on GM1-ganglioside binding enzyme-linked immunosorbent assays (GM1-ELISA). Real-time PCR of three generations (T3, T4, and T5) in homozygous lines (LCI-11) showed single copies of LTB, CTB, bar and Tnos. LTB and CTB proteins in rice transgenic lines were detected by Western blot analysis. Immunogenicity trials of rice-derived CTB and LTB antigens were evaluated through oral and intraperitoneal administration in mice, respectively. The results revealed that LTB- and CTB-specific IgG levels were enhanced in the sera of intraperitoneally immunized mice. Similarly, the toxin-neutralizing activity of CTB and LTB in serum of orally immunized mice was associated with elevated levels of both IgG and IgA. The results of the present study suggest that the combined expression of CTB and LTB proteins can be utilized to produce vaccines against enterotoxigenic strains of Escherichia coli and Vibrio cholera, for the prevention of diarrhea.
Plant Cell Reports | 2011
Ho Yong Chung; Hyun Ho Lee; Kyung Il Kim; Ha Young Chung; Jeon Hwang-Bo; Jong Hwa Park; Garry Sunter; Jong Bum Kim; Dong Hwa Shon; Wonyong Kim; In-Sik Chung
Biotechnology Letters | 2011
Jong Min Lee; Ha Young Chung; Kyung Il Kim; Ki Hyun Yoo; Jeon Hwang-Bo; In-Sik Chung; Jong-Hwa Park
KSBB Journal | 2012
Kyung Hwa Chang; Jong-Hwa Park; Do Hyung Kim; Ha Young Chung; Jeon Hwang-Bo; Hyun Ho Lee; Heeyoung Lee; Dong-Hwa Shon; Wonyong Kim; In-Sik Chung
Biotechnology Letters | 2012
Kyung Hwa Chang; Jong-Hwa Park; Ha Young Chung; Jeon Hwang-Bo; Hyun Ho Lee; Do-Hyung Kim; Yunjo Soh; In-Sik Chung
Biotechnology and Bioprocess Engineering | 2011
Ha Young Chung; Jeon Hwang-Bo; Seong-Ki Kim; Nam-In Baek; Youn Hyung Lee; In-Sik Chung; Jong-Hwa Park
Plant Biotechnology Reports | 2014
Ho Yong Chung; Jong Hwa Park; Hyun Ho Lee; Kyung Il Kim; Ha Young Chung; Garry Sunter; Jong Bum Kim; Wonyong Kim; In-Sik Chung
Plant Biotechnology Reports | 2012
Kyung Il Kim; Ha Young Chung; Ki Hyun Yoo; Jong-Hwa Park; Hyun Ho Lee; Yeon Ju Soek; Ki Sung Ko; Hyung Sik Kang; Kyung Jin Lee; Doo-Byoung Oh; Young Hee Joung; In-Sik Chung
Journal of the Korean Society of International Agricultue | 2016
Vimalraj Mani; Kang-Hyun Choi; Parthiban Subramanian; Chang-Muk Lee; Joon-Soo Sim; Ha Young Chung; Inchan Choi; Ja Choon Koo; Bum-Soo Hahn
Archive | 2009
In Sik Chung; 정인식; Kyung Il Kim; 김경일; Jong Min Lee; 이종민; Hyun Ho Lee; 이현호; Dong Hwa Shon; 손동화; Won Yong Kim; 김원용; Heeyoung Lee; 이희영; Ho Yong Chung; 정호용; Ha Young Chung; 정하영; Bo Jeon Hwang; 황보전; Ki Hyun Yoo; 유기현