Hacer Yapıcıoğlu Yıldızdaş

Polymorphism of the angiotensin-converting enzyme gene and angiotensin-converting enzyme activity in transient tachypnea of neonate and respiratory distress syndrome.

Background: Transient tachypnea of neonate (TTN) and respiratory distress syndrome (RDS) of the newborn are the most common cause of early respiratory distress in the immediate neonatal period. There is increasing evidence to support the role for the activation of the renin angiotensin system during acute lung injury. Objectives: The purpose of this study was to determine if there is a relationship between angiotensin-converting enzyme (ACE) I/D polymorphism, ACE activity and TTN and respiratory distress syndromes. Methods: Nineteen neonates with TTN, 20 neonates with RDS and 21 control infants are studied for ACE polymorphism and serum ACE activity. Results: Twenty six (43.3%) patients have DD polymorphism, 19 (31.7%) patients have ID polymorphism and 15 (25%) patients have II polymorphism. Serum ACE activity is 43.5 ± 1.8 (40–46) U/L in DD, 31.5 ± 2.3 (28–36) U/L in ID and 22.1± 2.1(19–46) U/L in II patient. Conclusions: The study could not find any difference in DD alleles and ACE activity between control group and TTN group. ACE polymorphism was not different between RDS group and control group in this study.

Evaluation of Score for Neonatal Acute Physiology and Perinatal Extension II and Clinical Risk Index for Babies with additional parameters

The aim of this study was to determine mortality risk by calculating Score for Neonatal Acute Physiology and Perinatal Extension II (SNAP‐PE‐II) and Clinical Risk Index for Babies (CRIB) score, and evaluate prediction of the effects of antenatal corticosteroid and surfactant treatment on mortality.

Evaluation of the SNAP‐PE‐II and CRIB scoring systems with additional parameters

The aim of this study was to determine mortality risk by calculating Score for Neonatal Acute Physiology and Perinatal Extension II (SNAP‐PE‐II) and Clinical Risk Index for Babies (CRIB) score, and evaluate prediction of the effects of antenatal corticosteroid and surfactant treatment on mortality.

The coincidence of necrotizing enterocolitis and rotavirus infections and potential associations with cytokines

BACKGROUND Necrotizing enterocolitis (NEC) is the most common gastrointestinal disease in neonatal intensive care units. Although the pathogenesis of NEC remains unclear, evidence suggests that infections, especially bacterial infections, may play an important role. Viral infections may also result in NEC. Several outbreaks of NEC associated with rotaviruses have been described previously. OBJECTIVE To investigate the association between rotavirus (RV) and serum interleukin (IL)-6 and IL-8 levels in infants with NEC. METHODS RV infections were prospectively studied using antigen detection in the stools of 31 infants with NEC. Additionally, serum levels of IL-6, IL-8 and tumour necrosis factor-alpha were tested using micro-ELISA at 0 h and 48 h after diagnosis of NEC. RESULTS Fecal specimens from 13 infants were positive, while fecal specimens from 18 infants were negative for RV according to antigen detection (RV+ and RV- groups, respectively). The mortality rate and the severity of NEC were not significantly different between the RV+ and RV- groups. IL-6 levels at 0 h and 48 h after diagnosis of NEC in RV+ infants were lower compared with RV- infants, while IL-8 levels were greater at 0 h and 48 h after diagnosis of NEC in RV+ infants compared with RV- infants. CONCLUSION A high prevalence of RV infection in neonates with NEC was found. Decreased IL-6 levels and increased IL-8 and tumour necrosis factor-alpha levels in RV+ neonates with NEC suggests a role for RV in NEC.

Non-persistent pesticides in breast milk in an agricultural area in Turkey

Abstract Background: Organophosphates, pythyreoids, carbamate pesticides and fungicides are heavily used in agriculture. They may have dangerous effects on newborn health especially on immune system and growth via prenatal transmission by placenta or postnatal transmission by breastfeeding. Methods: In 2015, 144 non-persistent pesticides in 64 milk samples of 32 mothers were studied by OuEChERS method in liquid chromatography/tandem mass spectrometer in neonatal Intensive Care Unit in Adana, a city in Cukurova region which is an important agricultural area in Turkey. Results: Pesticides were detected in milk samples of 11 mothers (34.3%) and 21 (32.8%) of milk samples. In five mothers, fungicides (in 5/10 samples propicanozole-PP, in 4/10 samples bromucanozole-BM), in five mothers, organophosphates (in 10/10 samples primyphosphomethyl-PPM), in one mother, both organophosphates and fungicide (in 1/2 samples PPM and in 1/2 samples buprimate) were detected. However, the estimated daily intakes (EDI) were less than acceptable daily intakes (ADI) for PPM, PP and BM, respectively. Conclusions: Although pesticides levels in human milk did not exceed the ADIs, we suggest monitoring pesticides in human breast milk especially for newborn health.

New biomarkers for antenatal infection: MICA and MICB gene expression in preterm babies

Abstract The human major histocompatibility complex class I chain-related gene A and B (MICA and MICB) is one of the genes in chromosome 6. As MIC expression is inducible by heat, viral infection, inflammation and DNA damage, the molecules have been thought to be stress markers for the cells. We aimed to find the level of mRNA concentrations of MICA and MICB in neonates without any evidence of early onset infection.

Mekonyum Aspirasyon Sendromu

Mekonyumlu amniyon sivisi normal gebeliklerin %13’unde gozlenir ve bu hastalarin %5’inde mekonyum aspirasyon sendromu gelisir. Mekonyum aspirasyon sendromu daha cok miadinda ve postmature bebeklerde gorulur. Mekonyum aspirasyon sendromunda hafif takipne ve dispneden agir solunum yetmezligi ve persistan pulmoner hipertansiyona kadar degisen cok farkli bir klinik tabloya rastlanabilir. Mekonyum aspirasyon sendromu kompleks fizyopatolojiye sahip ciddi bir yenidogan hastaligidir. Yenidogan doneminde mekonyum aspirasyon sendromu geciren bebeklerde, akut etkilerin yaninda uzun donemde anormal bronsial reaktivite, hisiltili solunum gibi solunum sistemi patolojilerine rastlanmaktadir. Tedavide bircok yardimci, ilave tedaviler de kullanilmaya ve denenmeye devam edilmektedir. Bu derlemede amniyon sivisi mekonyumlu olan ve mekonyum aspirasyon sendromlu bir bebegin antenatal, natal ve postnatal donemdeki yonetimi aktarilmistir.

Withdrawal syndrome and hypomagnesaemia and in a newborn exposed to valproic acid and carbamazepine during pregnancy.

The usage of drugs during pregnancy affect the fetus and the newborn. In this report, we present findings from a newborn baby, whose mother was epileptic, and was under the treatment of valproic acid and carbamazepine during pregnancy. We have found symptoms of withdrawal syndrome, hyponatremia and feeding problem, which was most probably related to exposure to the mentioned drugs. We have also diagnosed hypomagnesaemia and atrial septal defect 4 milimeters in diameter. There are already many reports about the side effects of valproic acid and carbamazepine usage during pregnancy. To the best of our knowledge, hypomagnesaemia has not yet been reported as a side effect. We think that hypomagnesaemia is also related to the usage of antiepileptics.

O-222 Evaluation Of The Influence Of Bifidobakterium Lactis 2011 And Hindiba Inulin On Feeding Intolerance And Necrotising Enterocolitis In Premature Babies

Aim To evaluate the influence of bifidobakterium lactis 2011 and hindiba inulin on feeding intolerance and necrotising enterocolitis in premature babies Material and method 89 premature babies with the diagnosis of feeding intolerance were enrolled in the study. Premature babies were divided into two groups; Study group (group 1) had Bifidobakterium Lactis (5 × 109 CFU) + Hindiba Inulin (900 mg) (MaflorR) liquefied with 10 ml sterile water with the dosage of 3 × 1 ml peroral while control group (group 2) did not have any medication for feeding intolerance. Results Gender and gestational weeks of the groups were not significantly different. B. Lactis ve Hindiba Inulin was started at mean 9.9 days and continued for mean 11.1 days. Time of starting oral feeding and time of full enteral feeding were longer in study group and this was statistically significant. (p < 0,05). Although NEC was not significantly different between groups (p > 0,05), babies in the study group diagnosed as in Grade 1 and did not progress, one third of the diagnosed babies in the control group progressed to Grade 2. When the groups were compared according to weight gain, study group gained more weights and it was statistically significant. (p < 0,05). Conclusion Probiotics and prebiotics may have positive effect due to higher weight gain and not advancing in NEC in study group having B. Lactis and Hindiba Inulin.