Haihui Cao
Boston Children's Hospital
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Publication
Featured researches published by Haihui Cao.
Magnetic Resonance in Medicine | 2008
Haihui Cao; Jerome L. Ackerman; Mirko I. Hrovat; Lila Graham; Melvin J. Glimcher; Yaotang Wu
The density of the organic matrix of bone substance is a critical parameter necessary to clinically evaluate and distinguish structural and metabolic pathological conditions such as osteomalacia in adults and rickets in growing children. Water‐ and fat‐suppressed proton projection MRI (WASPI) was developed as a noninvasive means to obtain this information. In this study, a density calibration phantom was developed to convert WASPI intensity to true bone matrix density. The phantom contained a specifically designed poly(ethylene oxide)/poly(methyl methacrylate) (PEO/PMMA) blend, whose MRI properties (T1, T2, and resonance linewidth) were similar to those of solid bone matrix (collagen, tightly bound water, and other immobile molecules), minimizing the need to correct for differences in T1 and/or T2 relaxation between the phantom and the subject. Cortical and trabecular porcine bone specimens were imaged using WASPI with the calibration phantom in the field of view (FOV) as a stable intensity reference. Gravimetric and amino acid analyses were carried out on the same specimens after WASPI, and the chemical results were found to be highly correlated (r2 = 0.98 and 0.95, respectively) to the WASPI intensity. By this procedure the WASPI intensity can be used to obtain the true bone matrix mass density in g cm–3. Magn Reson Med 60:1433–1443, 2008.
Bone | 2010
Haihui Cao; Ara Nazarian; Jerome L. Ackerman; Brian D. Snyder; Andrew E. Rosenberg; Rosalynn M. Nazarian; Mirko I. Hrovat; Guangping Dai; Dionyssios Mintzopoulos; Yaotang Wu
In this study, bone mineral density (BMD) of normal (CON), ovariectomized (OVX), and partially nephrectomized (NFR) rats was measured by (31)P NMR spectroscopy; bone matrix density was measured by (1)H water- and fat-suppressed projection imaging (WASPI); and the extent of bone mineralization (EBM) was obtained by the ratio of BMD/bone matrix density. The capability of these MR methods to distinguish the bone composition of the CON, OVX, and NFR groups was evaluated against chemical analysis (gravimetry). For cortical bone specimens, BMD of the CON and OVX groups was not significantly different; BMD of the NFR group was 22.1% (by (31)P NMR) and 17.5% (by gravimetry) lower than CON. For trabecular bone specimens, BMD of the OVX group was 40.5% (by (31)P NMR) and 24.6% (by gravimetry) lower than CON; BMD of the NFR group was 26.8% (by (31)P NMR) and 21.5% (by gravimetry) lower than CON. No significant change of cortical bone matrix density between CON and OVX was observed by WASPI or gravimetry; NFR cortical bone matrix density was 10.3% (by WASPI) and 13.9% (by gravimetry) lower than CON. OVX trabecular bone matrix density was 38.0% (by WASPI) and 30.8% (by gravimetry) lower than CON, while no significant change in NFR trabecular bone matrix density was observed by either method. The EBMs of OVX cortical and trabecular specimens were slightly higher than CON but not significantly different from CON. Importantly, EBMs of NFR cortical and trabecular specimens were 12.4% and 26.3% lower than CON by (31)P NMR/WASPI, respectively, and 4.0% and 11.9% lower by gravimetry. Histopathology showed evidence of osteoporosis in the OVX group and severe secondary hyperparathyroidism (renal osteodystrophy) in the NFR group. These results demonstrate that the combined (31)P NMR/WASPI method is capable of discerning the difference in EBM between animals with osteoporosis and those with impaired bone mineralization.
Journal of Magnetic Resonance Imaging | 2010
Yaotang Wu; Mirko I. Hrovat; Jerome L. Ackerman; Timothy G. Reese; Haihui Cao; Kirsten Ecklund; Melvin J. Glimcher
To demonstrate water‐ and fat‐suppressed proton projection MRI (WASPI) in a clinical scanner to visualize the solid bone matrix in animal and human subjects.
Journal of Magnetic Resonance Imaging | 2011
Yaotang Wu; Timothy G. Reese; Haihui Cao; Mirko I. Hrovat; Rostislav A. Lemdiasov; Jerome L. Ackerman
To implement solid state 31P MRI (31P SMRI) in a clinical scanner to visualize bone mineral.
International Journal of Molecular Medicine | 2007
A. Aria Tzika; Loukas G. Astrakas; Haihui Cao; Dionyssios Mintzopoulos; Ovidiu C. Andronesi; Michael Mindrinos; Jiangwen Zhang; Laurence G. Rahme; Konstantinos Blekas; Aristidis Likas; Nikolas P. Galatsanos; Rona S. Carroll; Peter McL. Black
International Journal of Molecular Medicine | 2008
A. Aria Tzika; Dionyssios Mintzopoulos; Katie Padfield; Julie Wilhelmy; Michael Mindrinos; Hongue Yu; Haihui Cao; Qunhao Zhang; Loukas G. Astrakas; Jiangwen Zhang; Yong-Ming Yu; Laurence G. Rahme; Ronald G. Tompkins
International Journal of Molecular Medicine | 2008
A. Aria Tzika; Loukas G. Astrakas; Haihui Cao; Dionyssios Mintzopoulos; Qunhao Zhang; Katie Padfield; Hongue Yu; Michael Mindrinos; Laurence G. Rahme; Ronald G. Tompkins
International Journal of Molecular Medicine | 2006
Qunhao Zhang; Haihui Cao; Loukas G. Astrakas; Dionyssios Mintzopoulos; Michael Mindrinos; John T. Schulz; Ronald G. Tompkins; Laurence G. Rahme; A. Aria Tzika
Archive | 2010
Haihui Cao; Jerome L. Ackerman; Mirko I. Hrovat; Melvin J. Glimcher; Yaotang Wu
Archive | 2009
Haihui Cao; Jerome L. Ackerman; T. D. Crenshaw; Melvin J. Glimcher; Yaotang Wu