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Dive into the research topics where Haijin Li is active.

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Featured researches published by Haijin Li.


Cell Research | 2010

Identification and characterization of microRNAs in raw milk during different periods of lactation, commercial fluid, and powdered milk products

Xi Chen; Chao Gao; Haijin Li; Lei Huang; Qi Sun; Yanye Dong; Chunliang Tian; Shengpu Gao; Hailin Dong; Danping Guan; Xiaoyun Hu; Shujian Zhao; Liang Li; Lin Zhu; Qiao Yan; Junfeng Zhang; Ke Zen; Chen-Yu Zhang

Recent baby formula milk powder contamination incidents have shown that the classic markers or standards in milk quality control are insufficient in identifying “manipulated” poor-quality milk. In the present study, we demonstrated for the first time that cow milk contains large amounts of microRNAs (miRNAs) and that the unique expression profile of milk-specific miRNAs can serve as a novel indicator and possible new standard for the quality control of raw milk and milk-related commercial products, such as fluid milk and powdered formula milk. First, using Solexa sequencing, we systematically screened miRNA expression in raw milk and identified a total of 245 miRNAs in raw milk. Unlike other classic biomarkers whose expression levels are nearly identical at different periods of lactation, individual miRNAs can be significantly altered during lactation process, implicating that miRNAs may be a more accurate indicator to reflect the quality alteration of milk. Second, using TaqMan probe-based miRNA quantitative RT-PCR, we further identified seven miRNAs that have a relatively consistent expression throughout the lactation process, and more importantly, the expression profile of these seven milk-specific miRNAs can serve as an ideal biomarker for discriminating poor-quality or “manipulated” milk from pure raw milk, as well as for the quality control of commercial milk products, such as fluid milk and powdered formula milk. Together, our findings provide a basis for understanding the physiological role of milk miRNAs and a new potential standard for determining the quality of raw milk or milk-related commercial products.


Archive | 2009

Non-small cell lung cancer detection marker, detection method thereof, related biochip and reagent kit

Chen-Yu Zhang; Ke Zeng; Junfeng Zhang; Yi Ba; Xi Chen; Haijin Li


Archive | 2011

Marker for detecting colon and rectum cancer as well as detection method, kit and biological chip thereof

Chen-Yu Zhang; Ke Zeng; Haijin Li


Archive | 2010

Method for regulating microrna content in organisms and uses thereof

Ke Zeng; 曾科; Chen-Yu Zhang; 张辰宇; Junfeng Zhang; 张峻峰; Haijin Li; 李海进


Archive | 2011

Method for regulating content of micro-ribonucleic acids in organism and use thereof

Ke Zeng; Chen-Yu Zhang; Junfeng Zhang; Haijin Li


Archive | 2010

Method for Modulating MicroRNA Content in Living Beings and the Use Thereof

Ke Zeng; Chen-Yu Zhang; Junfeng Zhang; Haijin Li


Archive | 2011

Novel technology for diagnosing liver cancer by utilizing microRNAs in serum

Chen-Yu Zhang; Ke Zeng; Junfeng Zhang; Haijin Li


Archive | 2011

Breast cancer detecting marker as well as detecting method, kit and biological chip thereof

Chen-Yu Zhang; Ke Zeng; Haijin Li


Archive | 2009

Non-small cell lung cancer detection marker, detection method thereof, related reagent kit and biochip

Chen-Yu Zhang; Ke Zeng; Junfeng Zhang; Yi Ba; Xi Chen; Haijin Li


Archive | 2012

MARKERS, METHODS, BIOCHIPS AND KITS FOR MILK QUALITY DETECTION

Chengyu Zhang; Ke Zeng; Junfeng Zhang; Chunliang Tian; Haijin Li

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Yi Ba

Tianjin Medical University Cancer Institute and Hospital

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