Haitham Mourad

Basic Emotion Recognition and Psychopathology in Schizophrenia

Socio-emotional competence is a key aspect of schizophrenia, both in terms of psychopathological vulnerability and outcome. In this respect, current research increasingly emphasizes the importance of deficits in facial expression recognition. The focus of the present study is the performance in recognizing 6 basic emotions (sadness, anger, happiness, fear, disgust, surprise) which play an essential role in shaping daily function and interpersonal interactions. A group of 20 patients diagnosed with DSM-IV schizophrenia were compared with a group of 20 matched controls on a facial expression recognition task, derived from the Karolinska Directed Emotional Faces (Lundqvist D, Flykt A, Öhmann A (1998) The Karolinska Directed Emotional Faces (KDEF). Stockholm (Sweden): Karolinska Institute), and were subsequently assessed with the Positive and Negative Syndrome Scale (PANSS). Facial expression recognition performance was significantly more impaired in patients, and was selectively correlated with the positive and cognitive dimensions of the positive and negative syndrome scale. Furthermore, significant group differences were found with respect to happiness and surprise.

Relations between a computerized shopping task and cognitive tests in a group of persons diagnosed with schizophrenia compared with healthy controls

Cognitive deficits are clearly associated with poor everyday life functioning in persons diagnosed with schizophrenia. However, previous studies have primarily used questionnaires to assess everyday life functioning. We developed a computerized real-life activity task (shopping task), where participants are required to shop for a list of seven grocery store items. Thirty individuals diagnosed with schizophrenia and 30 healthy controls were administered an extensive battery of cognitive tests and the computerized shopping task. Performances on the computerized shopping task significantly differentiated patients and healthy controls for several variables. Moreover, performance on the shopping task was significantly correlated with verbal episodic memory, cognitive flexibility, planning, processing speed, and inhibition. Finally, performance on the computerized shopping task was significantly correlated with various clinical variables and with a global measure of social functioning. These findings suggest that the computerized task used in the present study provides an indication of the level of everyday life functioning and cognitive functioning of persons diagnosed with schizophrenia, and, therefore, may be viewed as a valuable instrument in both an evaluation and remediation context.

Multitasking capacities in persons diagnosed with schizophrenia: A preliminary examination of their neurocognitive underpinnings and ability to predict real world functioning

Difficulties in everyday life activities are core features of persons diagnosed with schizophrenia and in particular during multitasking activities. However, at present, patients׳ multitasking capacities have not been adequately examined in the literature due to the absence of suitable assessment strategies. We thus recently developed a computerized real-life activity task designed to take into account the complex and multitasking nature of certain everyday life activities where participants are required to prepare a room for a meeting. Twenty-one individuals diagnosed with schizophrenia and 20 matched healthy controls completed the computerized task. Patients were also evaluated with a cognitive battery, measures of symptomatology and real world functioning. To examine the ecological validity, 14 other patients were recruited and were given the computerized version and a real version of the meeting preparation task. Results showed that performance on the computerized task was significantly correlated with executive functioning, pointing to the major implication of these cognitive processes in multitasking situations. Performance on the computerized task also significantly predicted up to 50% of real world functioning. Moreover, the computerized task demonstrated good ecological validity. These findings suggest the importance of evaluating multitasking capacities in patients diagnosed with schizophrenia in order to predict real world functioning.

Performance on a computerized shopping task significantly predicts real world functioning in persons diagnosed with bipolar disorder.

Persons diagnosed with bipolar disorder often suffer from cognitive impairments. However, little is known concerning how these cognitive deficits impact their real world functioning. We developed a computerized real-life activity task, where participants are required to shop for a list of grocery store items. Twenty one individuals diagnosed with bipolar disorder and 21 matched healthy controls were administered the computerized shopping task. Moreover, the patient group was assessed with a battery of cognitive tests and clinical scales. Performance on the shopping task significantly differentiated patients and healthy controls for two variables: Total time to complete the shopping task and Mean time spent to consult the shopping list. Moreover, in the patient group, performance on these variables from the shopping task correlated significantly with cognitive functioning (i.e. processing speed, verbal episodic memory, planning, cognitive flexibility, and inhibition) and with clinical variables including duration of illness and real world functioning. Finally, variables from the shopping task were found to significantly explain 41% of real world functioning of patients diagnosed with bipolar disorder. These findings suggest that the shopping task provides a good indication of real world functioning and cognitive functioning of persons diagnosed with bipolar disorder.

Performance on an Everyday Life Activity in Persons Diagnosed with Alcohol Dependency Compared to Healthy Controls: Relations between a Computerized Shopping Task and Cognitive and Clinical Variables

AIM Persons diagnosed with alcohol dependency often suffer from cognitive impairments. Little is known, however, concerning how these cognitive deficits impact complex, everyday life activities. We set out to better characterize the nature of everyday life difficulties in patients with alcohol dependency using a computerized shopping task. METHODS A computerized real-life activity task (shopping task) required participants to shop for a list of eight grocery store items. Twenty individuals diagnosed with alcohol dependency and 20 healthy controls were administered a battery of cognitive tests, clinical scales and the shopping task. RESULTS Performance on the shopping task significantly differentiated patients and healthy controls for several variables and, in particular, for total time. Total time to complete the task correlated significantly with poor performance on measures of processing speed, verbal episodic memory, cognitive flexibility and inhibition. Total time was significantly correlated with poorer everyday life functioning and longer duration of illness. CONCLUSION This computerized task is a good proxy measure of the level of everyday life and cognitive functioning of persons diagnosed with alcohol dependency.

1006 – Basic emotion recognition and psychopathology in schizophrenia

Socio-emotional competence is a key aspect of schizophrenia, both in terms of psychopathological vulnerability and outcome. In this respect, current research increasingly emphasizes the importance of deficits in facial expression recognition. The focus of the present study is the performance in recognizing six basic emotions (sadness, anger, happiness, fear, disgust, surprise), which play an essential role in shaping daily function and interpersonal interactions. A group of 20 patients diagnosed with DSM-IV schizophrenia were compared with a group of 20 matched controls on a facial expression recognition task, derived from the Karolinska Directed Emotional Faces (KDEF; Lundqvist et al., 1998), and were subsequently assessed with the Positive and Negative Syndrome Scale (PANSS). Facial expression recognition performance was significantly more impaired in patients, and was selectively correlated with the Positive and Cognitive dimensions of the PANSS. Furthermore, significant group differences were found with respect to joy and surprise.