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Dive into the research topics where Hajime Ohtani is active.

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Featured researches published by Hajime Ohtani.


Platelets | 2009

The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients.

Shosaku Nomura; Norihito Inami; Akira Shouzu; Seitarou Omoto; Yutaka Kimura; Nobuyuki Takahashi; Atsushi Tanaka; Fumiaki Urase; Yasuhiro Maeda; Hajime Ohtani; Toshiji Iwasaka

Platelet-derived microparticles (PDMP) play an important role in the pathogenesis of diabetic vasculopathy, and statins or eicosapentaenoic acid (EPA) have been shown to have a beneficial effect on atherosclerosis in hyperlipidemic patients. However, the influence of EPA and statins on PDMP and adiponectin in atherosclerosis is poorly understood. We investigated the effect of pitavastatin and EPA on circulating levels of PDMP and adiponectin in hyperlipidemic patients with type II diabetes. A total of 191 hyperlipidemic patients with type II diabetes were divided into three groups: group A received pitavastatin 2 mg once daily (n = 64), group B received EPA 1800 mg daily (n = 55) and group C received both drugs (n = 72). PDMP and adiponectin were measured by ELISA at baseline and after 3 and 6 months of drug treatment. Thirty normolipidemic patients were recruited as healthy controls. PDMP levels prior to treatment in hyperlipidemic patients with diabetes were higher than levels in healthy controls (10.4 ± 1.9 vs. 3.1 ± 0.4 U/ml, p < 0.0001), and adiponectin levels were lower than controls (3.20 ± 0.49 vs. 5.98 ± 0.42 µg/ml, p < 0.0001). PDMP decreased significantly in group B (before vs. 6M, 10.6 ± 2.0 vs. 8.0 ± 1.7 U/ml, p < 0.01), but not in group A (before vs. 6M, 9.4 ± 1.9 vs. 9.6 ± 1.7 U/ml, not significant). In contrast, group A exhibited a significant increase in adiponectin levels after treatment (before vs. 6M, 3.29 ± 0.51 vs. 4.16 ± 0.60 µg/ml, p < 0.001). Furthermore, group C exhibited significant improvement in both PDMP and adiponectin levels after treatment (PDMP, before vs. 6M, 11.2 ± 2.0 vs. 4.5 ± 2.7 U/ml, p < 0.001; adiponectin, before vs. 6M, 3.24 ± 0.41 vs. 4.02 ± 0.70 µg/ml, p < 0.001). Reductions of PDMP in combined therapy were significantly greater than those observed with EPA alone (p < 0.05 by ANOVA). In addition, soluble CD40 ligand exhibited almost the same change as PDMP in all therapy groups. These results suggest that pitavastatin possesses an adiponectin-dependent antiatherosclerotic effect, and this drug is able to enhance the anti-platelet effect of EPA. The combination therapy of pitavastatin and EPA may be beneficial for the prevention of vascular complication in hyperlipidemic patients with type II diabetes.


Japanese Circulation Journal-english Edition | 2008

PJ-727 Inhibition of iNOS Uncoupling by Tetrahydrobiopterin Restores Tolerance to Ischemia/Reperfusion Injury in Streptozotocin-Induced Diabetic Rat Heart(Myocardial ischemia / reperfusion, basic / clinical(04)(IHD),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Toru Okazaki; Hajime Ohtani; Koji Yamashita; Akira Moriguchi; Daisuke Satoh; Seiji Matsuhisa; Yuzo Akita; Chiharu Enoki; Hiroji Imamura; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2008

OE-308 Sarcolemmal Dystrophin is an End-Target of RISK Activation Mediated by Ischemic Postconditioning against Myocardial Infarction(Myocardial ischemia/reperfusion, basic/clinical(01)(IHD),Oral Presentation(English),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Akira Moriguchi; Hajime Ohtani; Koji Yamashita; Toru Okazaki; Daisuke Satoh; Seiji Matsuhisa; Yuzo Akita; Chiharu Enoki; Hiroji Imamura; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2008

PJ-370 Investigation of Actual Condition of Digestibility Ulcer Treatment with Low Dosage Aspirin(Preventive medicine/Epidemiology/Education(06)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Junji Iwasaka; Naotsugu Oyama; Chihiro Oishi; Koji Yamashita; Toru Okazaki; Daisuke Satoh; Takanao Ueyama; Seiji Matsuhisa; Yuzo Akita; Haeng Nam Park; Yoshihiro Yamamoto; Hajime Ohtani; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2008

PJ-480 Inhibition of Nitric Oxide Synthase Uncoupling Ameliorates Cardiac Dysfunction in Streptozotocin-induced Diabetic Mice(Diabetes/Obesity/Metabolic syndrome(12)(H),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Hiromi Jo; Hajime Ohtani; Atsushi Kosaki; Toru Okazaki; Kouji Yamashita; Yuzo Akita; Seiji Matsuhisa; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2008

OJ-182 The Mechanism of Oxidative Stress-induced Refractoriness to Ischemic Preconditioning in Aged Heart(Myocardial ischemia / reperfusion, basic / clinical(02)(IHD),Oral Presentation (Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation Society)

Koji Yamashita; Hajime Ohtani; Toru Okazaki; Akira Moriguchi; Daisuke Satoh; Seiji Matsuhisa; Yuzo Akita; Chiharu Enoki; Hiroji Imamura; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2007

PE-564 Comparison of Safety of Mesenchymal Stem Cell Transplantation between Intracoronary Infusion and Direct Injection in Rats with Myocardial Infarction(Regeneration (angiogenesis/myocardial regeneration)-3, The 71st Annual Scientific Meeting of the Japanese Circulation Society)

Chiharu Enoki; Hajime Ohtani; Daisuke Satoh; Toru Okazaki; Akira Moriguchi; Reiji Hattori; Toshiji Iwasaka; Hiroji Imamura


Japanese Circulation Journal-english Edition | 2006

PJ-106 Is Myocardial Hibernation a Self-defense Mechanism Against Contractile Force-induced Oncosis in Energy-depleted Myocyte?(Myocardial ischemia-reperfusion, basic/clinical-5 (IHD) PJ18,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Hajime Ohtani; Seiji Matsuhisa; Yuzo Akita; Shiori Kyoi; Chiharu Enoki; Kimiko Tatsumi; Hiroji Imamura; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2006

PJ-105 Activation of Mitochondrial K_ Channels and Inhibition of Glycogen Synthase Kinase-3β Independently Contribute to Cardioprotection Mediated by Ischemic Preconditioning(Myocardial ischemia-reperfusion, basic/clinical-5 (IHD) PJ18,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Hajime Ohtani; Kenichi Manabe; Seiji Matsuhisa; Yuzo Akita; Shiori Kyoi; Chiharu Enoki; Hiroyoshi Fujiwara; Hiroji Imamura; Toshiji Iwasaka


Japanese Circulation Journal-english Edition | 2006

OJ-186 Role of Phosphatidylinositol 3-kinase-mTOR Cascade in Self-renewal and Myogenic Differentiation of Bone Marrow-derived Mesenchymal Stem Cells(Regeneration (angionenesis/myocardial regeneration)-3 (M) OJ31,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

Hajime Ohtani; Takayuki Okada; Chiharu Enoki; Yue Wu; Kimiko Tatsumi; Seiji Matsuhisa; Yuzo Akita; Shiori Kyoi; Toshiji Iwasaka; Hiroji Imamura

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Toshiji Iwasaka

Kansai Medical University

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Hiroji Imamura

Kansai Medical University

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Seiji Matsuhisa

Kansai Medical University

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Yuzo Akita

University of Connecticut

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Shiori Kyoi

Kansai Medical University

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Toru Okazaki

Kansai Medical University

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Kimiko Tatsumi

Kansai Medical University

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Akira Moriguchi

Kansai Medical University

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