Halina Milgrom

Treatment of kaposi's sarcoma with vinblastine

Fourteen patients with Kaposis sarcoma (KS) were treated systemically with vinblastine sulfate in a low‐dose regimen and compared with 23 patients reported in the medical literature. The therapeutic results in our series were excellent in terms of regression of cutaneous lesions. Vinblastine appears to be a drug that is well suited for the management of KS in an outpatient setting. Intravenous therapy may be supplemented with intralesional or intraarterial vinblastine.

Squamous cell carcinoma in dominant type epidermolysis bullosa dystrophica.

The unusual genetic disorder epidermolysis bullosa dystrophica has been reported in several patients in whom the chronic cutaneous scars led to the development of cutaneous squamous cell carcinoma. However, only one of these previously reported cases involved the autosomal dominant form of the disease; the remainder occurred in its recessive counterpart. We report the second and third patients with squamous cell carcinoma associated with the dominant form of epidermolysis bullosa dystrophica. In addition, we not only observed the previous electron microscopic findings of decreased numbers of anchoring fibrils beneath the basal lamina but have also noted marked disruption of the basal lamina itself.

Unusual Clinical Presentation of Epidermotropic Cutaneous Lymphoma

Abstract: A 35‐year‐old black woman developed numerous vitiligo‐like small hypopigmented macules on the upper and lower extremities. Histologically the lesions were consistent with epidermotropic mycosis fungoides or pagetoid reliculosis. The patient is presented because of a clinical picture unusual for either of the above microscopic diagnoses.

Breast carcinoma and basal cell epithelia after X-ray therapy for hirsutism

We report a 60‐year‐old woman with a history of x‐ray therapy for generalized hirsutism at 20 years of age who at the age of 37 years developed the first of numerous basal cell epitheliomas on her trunk, including chest, on a background of radiation damaged skin. At the age of 51 years one of the basal cell epitheliomas was biopsied and an incidental histologic finding was a breast carcinoma. The basal cell epithelioma is clearly linked with x‐ray exposure; breast cancer is less so although there is impressive epidemiologic evidence supporting an association between human breast cancer and radiation exposure. In view of an association between thyroid cancer and dermatologic x‐ray therapy, further investigation of such an association with breast cancer should be considered. It may be wise to evaluate patients who received dermatologic x‐ray exposure to their breasts for possible breast cancer and to consider radiation induced skin damage on or near the skin overlying the thyroid or breasts as a cutaneous marker of internal malignancy or potential internal malignancy.

Unusual clinical presentation of epidermotropic cutaneous lymphoma. Small hypopigmented macules.

ABSTRACT: A 35‐year‐old black woman developed numerous vitiligo‐like small hypopigmented macules on the upper and lower extremities. Histologically the lesions were consistent with epidermotropic mycosis fungoides or pagetoid reticulosis. The patient is presented because of a clinical picture unusual for either of the above microscopic diagnoses.

Local Chemotherapy in Cutaneous and Mucosal Neoplasia.

Excerpt Local administration of antimitotic agents to primary and metastatic tumors in the skin was explored in animals and in man to develop model systems of neoplasia. Several antitumor agents we...