Haluk Recai Ünalp

Analysis of Risk Factors Affecting the Development of Seromas Following Breast Cancer Surgeries: Seromas Following Breast Cancer Surgeries

Abstract:  This study aimed to determine the effects of demographic, clinical, and therapeutic variables in development of seromas. The relation between development of seromas and age, preference for surgery, tumor size, existence of axillary lymph nodes and lymph nodal metastases, number of lymph nodes removed, type of surgical equipments used, drainage duration, drainage flow rate, and whether or not neoadjuvant chemotherapy was received; dead volume was reduced; or pressure garment was used in patients who received surgery due to breast cancer between 2000 and 2005 years. Mean age of 119 patients included in the study was 53.13 ± 13.26 (range 26–79). Seromas were observed in 17 (14.28%) patients. In multivariate logistic regression analysis an association of postoperative seroma formation was noted with a drainage flow rate greater than 50 mL/day after 48th hours following breast surgery (p = 0.007), while other variables investigated herein are not associated with development of seromas. We conclude that a drainage flow rate greater than 50 mL/day after 48th hours is a predicting factor for seroma formation in breast cancer patients. Thus, we do not recommend terminating the drainage before flow rate at 48 hours is seen and daily drainage is lower than acceptable limit.

Urgent abdominal re-explorations.

BackgroundTreatment of a number of complications that occur after abdominal surgeries may require that Urgent Abdominal Re-explorations (UARs), the life-saving and obligatory operations, are performed. The objectives of this study were to evaluate the reasons for performing UARs, outcomes of relaparotomies (RLs) and factors that affect mortality.MethodsDemographic characteristics; initial diagnoses; information from and complications of the first surgery received; durations and outcomes of UAR(s) performed in patients who received early RLs because of complicated abdominal surgeries in our clinic between 01.01.2000 and 31.12.2004 were investigated retrospectively. Statistical analyses were done using the chi-square and Fisher exact tests.ResultsEarly UAR was performed in 81 out of 4410 cases (1.8%). Average patient age was 50.46 (13–81) years with a male-to-female ratio of 60/21. Fifty one (62.96%) patients had infection, 41 (50.61%) of them had an accompanying serious disease, 24 (29.62%) of them had various tumors and 57 (70.37%) patients were operated under emergency conditions during first operation. Causes of urgent abdominal re-explorations were as follows: leakage from intestinal repair site or from anostomosis (n:34; 41.97%); hemorrhage (n:15; 18.51%); intestinal perforation (n:8; 9.87%); intraabdominal infection or abscess (n:8; 9.87%); progressive intestinal necrosis (n:7; 8.64%); stomal complications (n:5; 6.17%); and postoperative ileus (n:4; 4.93%). Two or more UARs were performed in 18 (22.22%) cases, and overall mortality was 34.97% (n:30). Interval between the first laparotomy and UAR averaged as 6.95 (1–20) days, and average hospitalization period was 27.1 (3–78) days.Mortality rate was found to be higher among the patients who received multiple UARs. The most common (55.5%) cause of mortality was sepsis/multiple organ failure (MOF). The rates for common mortality and sepsis/MOF-dependent mortality that occured following UAR were significantly higher in patients who received GIS surgery than in those who received other types of surgeries (p:0.000 and 0.010, respectively).ConclusionUARs that are performed following complicated abdominal surgeries have high mortality rates. In particular, UARs have higher mortality rates following GIS surgeries or when infectious complications occur. The possibility of efficiently lowering these high rates depends on the success of the first operations that the patient had received.

Axillary lymph node metastasis from serous ovarian cancer: a case report and review of the literature.

IntroductionThe symptoms and findings of ovarian cancer are parallel with the degree of intra-abdominal expansion of the tumor. Metastases in the early stage occur by peritoneal fluid’s tracking via the circulatory system. Renal and cerebral metastases of ovarian cancer have been previously reported, but axillary lymph node metastasis is quite rare. Axillary lymph node metastasis usually occurs in the advanced stage.Materials and methodsWe present a 47-year-old female who had applied adjuvant chemotherapy following cyto-reductive surgery because of stage 3C ovarian cancer. Axillary lymph node metastasis was detected in the postoperative 32 months.ConclusionAs tumors in axillary lymph nodes are found in patients with an ovarian carcinoma, the treatment is also so important too. Metastasis to the breast be differentiated accurately from primary breast cancer, because prognosis and treatment differ significantly. Accurate diagnosis of these metastases may allow more appropriate theraphy such as chemotherapy and prevent the patient from an unnecessary major breast surgery.

Analysis of early relaparotomy after lower gastrointestinal system surgery

PurposeTo evaluate the complications after lower gastrointestinal system (GIS) operations, and to investigate the reasons for and outcomes of relaparotomy (RL), and the factors influencing its mortality rate.MethodsThe subjects of this retrospective study were 38 patients who underwent early RL for complications of lower GIS surgery. We analyzed the demographic features and initial diagnoses of the patients, the reasons for their initial surgery and their postoperative complications, and the number, duration, and outcome of early RLs.ResultsThe average patient age was 54.8 ± 16.2 years and the male:female ratio was 30:8. Early RL was performed for the following complications: leakage of an intestinal repair or anastomosis (n = 17, 44.7%); intraabdominal infection or abscess (n = 8, 21%); stomal complications (n = 5, 13.2%); necrosis caused by mesenteric arterial thrombosis (n = 4, 10.5%); hemorrhage (n = 2, 5.3%); and intestinal rupture (n = 2, 5.3%). A mortality rate of 36.8% (n = 14) was attributed mainly to infections (n = 27, 71.4%). The average interval between the first laparotomy and RL was 5.5 ± 3.5 days, and the average hospital stay was 27.1 ± 19.4 days.ConclusionsRelaparotomy performed soon after major lower GIS surgery is associated with a high mortality rate. Thus, to decrease both the RL and mortality rates, complicated surgery should ideally be performed by experienced surgeons in fully equipped facilities.

Thick-needle vacuum-assisted biopsy technique for inflammatory breast carcinoma diagnosis

PURPOSE Inflammatory breast carcinoma (IBC) is a rare clinicopathological cancer type with unique clinical features and a poor prognosis. In this disease, there is generally no palpable mass in the breast. IBC can be mistakenly diagnosed as mastitis and patients may receive a delayed diagnosis and treatment, since these two disorders cause similar pathological appearences on the breast. Clinical suspicion of the disease followed by histopathological observation of occluded dermal lympthatics by tumor emboli leads to definitive diagnosis of IBC. METHODS Here, we report our experiences in diagnosing IBC using Thick-Needle Aspiration Biopsy (TNAB). RESULTS Eight patients having clinically suspected IBC, received TNAB. IBC was definitively diagnosed upon observation in histopathological examination of occluded dermal lymphatics by tumor emboli since TNAB allowed adequate tissue sampling. CONCLUSION In this study, we showed that IBC can be reliably diagnosed using TNAB.

Surgical treatment of hepatic hydatic disease during pregnancy: report of two cases

Current treatment options for hepatic hydatid disease include surgery, medical treatment, and percutaneous drainage. However, the choice between these treatment modalities for pregnant women is still controversial. We reported in this article two pregnant patients with hepatic hydatid cysts who underwent surgical treatment.