Hamit Serdar Başbuğ

Transfusion-related acute lung injury following coronary artery bypass graft surgery

Blood transfusion is sometimes a necessary procedure during or following coronary artery bypass graft (CABG) surgery. However, transfusion-related acute lung injury (TRALI)/possible TRALI is a rare and fatal complication and characterized by acute hypoxemia and non-cardiogenic pulmonary edema that occurs within 6 hours following a transfusion. Anti-leukocyte antibodies or, possibly, other bioactive substances cause inflammation and capillary endothelial destruction in susceptible recipients’ lungs. Prompt diagnosis and mechanical ventilatory support are important. A successful treatment of two male patients following CABG surgery, compatible with TRALI/possible TRALI, is presented here.

Leg oedema due to low-dose risperidone during maintenance monotherapy of schizophrenia

ABSTRACT Drug-related peripheral leg oedema is most commonly associated with steroids, nonsteroidal anti-inflammatory, antihypertensives, and immunosuppressive agents. The second-generation antipsychotic risperidone is rarely associated with such oedematous complications. This adverse effect of risperidone occurs with a higher incidence in higher doses according to its dose-dependent nature. In this paper, a rare case of small maintenance dose risperidone-induced peripheral leg oedema in a schizophrenia patient was reported.

Ischemia-modified albumin: a unique marker of global metabolic risk in schizophrenia and mood disorders

ABSTRACT OBJECTIVE: Conformational change in the last four amino acid of the albumin’s N-terminus is called ischemia-modified albumin (IMA). Metabolic stress factors such as ischemia, hypoxia, acidosis or endothelial injury may cause these conformational modifications. In this study, we hypothesized that the plasma IMA level changes might help to determine the global metabolic risk in bipolar disorder (BD), unipolar depression (UD), and schizophrenia (SZ). Therefore, it was aimed to investigate metabolic risk factors affecting IMA levels in this study. Modification of the albumin molecule might be a marker of global metabolic risk in schizophrenia and mood disorders. METHOD: The study included 32 patients with BD, 32 patients with UD, 28 patients with SZ and 34 healthy individuals. For determining the IMA levels, standard amounts of cobalt ions were added to the serums, and the quantity of disengaged cobalt ions was measured by colorimetric assay. RESULTS: IMA (F = 3.04, p = 0.032) levels differed between the groups. IMA levels of the BD group were significantly higher than the healthy control group (p = 0.048). White blood cell count in the BD group (p = 0.034) and total oxidant status (TOS) in the SZ group (p < 0.001) were the determinants of IMA levels with linear regression analysis. CONCLUSION: Elevation of IMA levels may indicate a global metabolic risk, and IMA levels are elevated in the BD group in this study. Determinants of IMA levels may indicate the significant metabolic risk in patient groups. Oxidative stress (OS) was the determinant of IMA levels in the SZ, and white blood cell count was the determinant of IMA levels in the BD group. Although the IMA levels were higher in all patient groups, the statistical significance appeared only in the BD group. Elevated IMA level was due to elevated OS in the SZ group, whereas the immunity in the BD group.

An unusual complication of a long-acting injectable antipsychotic: deep venous thrombosis caused by olanzapine pamoate

ABSTRACT Antipsychotic drugs are widely used in psychiatry and are associated with an increased risk of adverse effects such as venous thromboembolism. Olanzapine pamoate is a long-acting injectable form of the second-generation antipsychotic agent. It is used especially in schizophrenia patients who are nonadherent to their prescription due to various reasons. Since the introduction of this newer depot form of olanzapine, it became more commonly prescribed and nearly replaced the conventional oral agent. Deep venous thrombosis (DVT) is a severe, life-threatening condition which is somehow mostly underestimated or ignored by the psychiatrists. Although the risk of DVT due to antipsychotic drug therapy has been mentioned in various studies, the relationship with olanzapine pamoate was not referred to in the available literature. Here, a DVT after the use of olanzapine pamoate was introduced.

Alice in Wonderland syndrome: a strange visual perceptual disturbance

ABSTRACT - “Who are you?” said the Caterpillar. - Alice replied, rather shyly, “I – I hardly know, sir, just at present- at least I know who I was when I got up this morning, but I think I must have been changed several times since then.” - “What do you mean by that?” said the Caterpillar sternly. “Explain yourself!”, - “I can’t explain myself, I’m afraid, sir,” said Alice, “because I’m not myself, you see.” - “I don’t see,” said the Caterpillar. - “I’m afraid I can’t put it more clearly,” Alice replied very politely, “for I can’t understand it myself to begin with; and being so many different sizes in a day is very confusing.” (Lewis Carroll L., Alice’s adventures in Wonderland. London: Macmillan & Co; 1865)The term Alice in Wonderland syndrome (AIWS) was initially coined by John Todd in 1955 to describe some weird somesthetic aura involving the shape or size of the objects and body parts. The name of this disorder was inspired by the novel of Lewis Carroll and his novel hero Alice. Alice appeared to experience many body size changes throughout the course of the story. Alice even feels her body shrink (microsomatognosia) or growing unexplainably taller (macrosomatognosia) than she actually is. Such visual perceptual distortions may occur in epileptic seizures, encephalitis, drug intoxication, and may be described in patients with schizophrenia or brain lesions. However, migraine and epilepsy are highly involved diseases that cause this type of aural symptoms. In this paper, a unique presentation of a young AIWS patient who has been depressed by experiencing an intermittent perceptual disturbance of seeing her cat as a huge tiger was reported.

An extreme physical reaction in misophonia: stop smacking your mouth!

ABSTRACT Misophonia is described as a condition in which negative emotions and negative physical reactions are triggered by particular sounds. The patients with misophonia demonstrate hatred and extreme intolerance against specific non-dominant and repetitive sounds. It is a severe psychiatric disorder rather than a mere obsession. Its symptoms may vary from mild to severe. Although some patients can dissemble and passed out, some may lose their control. In severe cases, involuntary physical violence may be observed. Although it is usually perceived as a spoil by the society, it may cause the patient’s life become unbearable. In this paper, the physical violence of a misophonia patient directed to a dinner guest who smacks his mouth during eating was reported. Unfortunately, the patient could not achieve to exclude himself from the source of disturbance before exhibiting the adverse physical reaction. Therefore, this case becomes important in demonstrating the extreme involuntarily reactive nature of misophonia.

Emergent operation of an extensive pulmonary damage after thoracal gunshot assault

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Association of the Zwolle Score with Fragmented QRS Complex: A Combined Prognostic Tool for Primary Angioplasty in ST Elevation Myocardial Infarctions -

Introduction: We aimed to introduce the prognostic value of simultaneously calculated fragmented QRS and Zwolle scores as a new scoring system in primary PCI of the STEMI patients. Method: Two hundred fifty-nine STEMI patients were classified as fragmented QRS complex group (fQRS) and non-fragmented QRS complex group (non-fQRS) according to the fragmentation of QRS complex in electrocardiography. These two groups according to whether Zwolle score ≥3 were also classified as high Zwolle score with fQRS complex, high Zwolle score with the non-fQRS complex, the low Zwolle score with fQRS complex, and low Zwolle score with the non-fQRS complex group. The hospitalization data of the patients were analyzed. Results: In the fQRS group compared with the non-fQRS group, wider QRS (105.2±9.7 vs. 88±7.1, p

Assessment of relation between aortic elastic properties and the complexity of coronary artery disease.

Assessment of relation between aortic elastic properties and the complexity of coronary artery disease Ahmet Karakurt, Cennet Yildiz, Abdulmelik Yildiz & Hamit Serdar Başbuğ To cite this article: Ahmet Karakurt, Cennet Yildiz, Abdulmelik Yildiz & Hamit Serdar Başbuğ (2016) Assessment of relation between aortic elastic properties and the complexity of coronary artery disease, Acta Cardiologica, 71:3, 267-273, DOI: 10.1080/AC.71.3.3152086 To link to this article: https://doi.org/10.1080/AC.71.3.3152086