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Featured researches published by Hande Senol.


Medical Principles and Practice | 2016

The Association between Central Adiposity and Autonomic Dysfunction in Obesity

Güzin Fidan-Yaylali; Yalin Tolga Yaylali; Çağdaş Erdogan; Beray Can; Hande Senol; Bengi Gedik-Topçu; Senay Topsakal

Objective: To determine the relationship between central adiposity parameters and autonomic nervous system (ANS) dysfunction. Subjects and Methods: The study included 114 obese individuals without any cardiovascular risk factors. Weight (in kg), height (in m), and waist circumference (WC; in cm) were measured and body mass index was calculated. Echocardiographic examination was performed to measure left ventricular mass and epicardial fat thickness (EFT). All the participants underwent an exercise test and electrophysiological evaluation using electromyography. Heart rate recovery (HRR) at 1-5 min, R-R interval variation at rest and during hyperventilation, and sympathetic skin response were measured. Pearsons correlation analysis was used. Multiple linear regression analysis was used to identify the factors associated with autonomic dysfunction. Results: The HRR at 1-5 min was negatively correlated with WC and age (WC-HRR1: r = -0.32; WC-HRR2: r = -0.31; WC-HRR3: r = -0.26; WC-HRR4: r = -0.23; WC-HRR5: r = -0.21; age-HRR2: r = -0.32; age-HRR3: r = -0.28; age-HRR4: r = -0.41; age-HRR5: r = -0.42). Age was the only independent predictor of reduced HRR at 1-5 min. In addition, WC predicted a reduced HRR at 3 min. There were no significant associations between central obesity and electrophysiological parameters. EFT was not associated with ANS dysfunction. Conclusion: In this study, central adiposity and aging were associated with ANS dysfunction in obese individuals. The WC could be a marker of ANS dysfunction in obese individuals without any cardiovascular risk factors. The HRR assessment at a later decay phase could be more valuable for evaluating ANS function than during early recovery.


Biorheology | 2014

Acute effects of continuous and intermittent aerobic exercises on hemorheological parameters: A pilot study

Gulin Findikoglu; Emine Kilic-Toprak; Ozgen Kilic-Erkek; Hande Senol; Melek Bor-Kucukatay

BACKGROUND Acute hemorheological responses to different types of aerobic exercises have never been compared in a single study in healthy people. OBJECTIVE We aimed to compare acute effects of high intensity intermittent exercise (HIIE) and moderate intensity continuous exercise (MICE) on hemorheological parameters, in healthy young subjects. METHODS A total of 34 sedentary young adults (12 males, 22 females) with a mean age of 20.0 ± 2.1 years were randomly assigned to HIIE, MICE or non-exercise groups. MICE exercised at the power corresponding to 50% of heart rate reserve (HRR) continuously for 25 min. HIIE exercised at the power corresponding to 100% of HRR for 30 s followed by 30 s rest for 25 min. The non-exercise group rested. Blood samples were collected before and after exercise and studied for blood count, whole blood viscosity (WBV), plasma viscosity (PV) and red blood cell (RBC) elongation at nine different shear stresses. RESULTS WBV, PV, RBC elongation of MICE and HIIE groups were not found to be statistically different from each other or from the non-exercise group. Compared to the non-exercise group, there was a significant increase in white blood cell (WBC) and RBC counts in the MICE group. CONCLUSIONS Different types of aerobic exercises, namely MICE, HIIE are not different from each other in terms of hemorheological parameters immediately after exercise.


Clinical Hemorheology and Microcirculation | 2015

Investigation of hemorheological parameters at the diagnosis and the follow-up of nutritional vitamin B12 deficient children

Hazal Tancer-Elci; Yasemin Isik-Balci; Melek Bor-Kucukatay; Emine Kilic-Toprak; Ozgen Kilic-Erkek; Hande Senol; Hülya Aybek

We aimed to investigate the effects of vitamin B12 deficiency on hemorheological parameters, and the changes in these parameters following vitamin B12 treatment. 33 patients (mean-age:7 ± 5.7 years) diagnosed as nutritional vitamin B12 deficiency, and 31 age and sex matched controls (mean-age:7.1 ± 5.2 years) were enrolled. Erythrocyte deformability and aggregation were determined by an ectacytometer, plasma and whole blood viscosities by a cone-plate rotational viscometer. The differences between patients and controls were compared. Hemorheological parameters were repeated in the patient group following vitamin B12 treatment, and the results were compared with the initial results. In vitamin B12 deficiency, erythrocyte deformability and whole blood viscosity were found to be significantly decreased, eythrocyte aggregation was found to be significantly increased compared with the controls. Plasma viscosity was found to be decreased in deficiency but this decrease was not statistically significant. In patient group, erythrocyte deformability, whole blood and plasma viscosities were found to be significantly increased and erythrocyte aggregation was significantly decreased, after treatment. This study indicates that vitamin B12 deficiency has important effects on hemorheological parameters and adequate treatment of deficiency not only corrects the hematological parameters, but also by helping to normalize the hemorheological parameters, may contribute to the regulation of microvascular perfusion.


Acta Cardiologica | 2018

Hemorheological dysfunction in cardiac syndrome X

Emine Kilic-Toprak; Olga Yaylali; Yalin Tolga Yaylali; Yasin Ozdemir; Doğangün Yüksel; Hande Senol; Tarık Sengoz; Melek Bor-Kucukatay

Abstract Background: Cardiac syndrome X (CSX) is often described as angina or angina-like chest pain with a normal coronary arteriogram, yet the underlying pathophysiological mechanisms have not been fully elucidated. The aim of the current study was to determine alterations in blood rheology (erythrocyte aggregation and deformability, plasma viscosity – PV) in patients with CSX. Methods: The study comprised 26 CSX patients (55.77 ± 12.33 years) and 37 age- and sex-matched (56.32 ± 11.98 years) healthy controls. Erythrocyte aggregation and deformability were measured by an ektacytometer and PV with a rotational viscometer. Results: Erythrocyte deformability measured at 1.69 and 3.00 Pa was lower in the CSX patients compared to the controls (p = .0001 and .017, respectively). Erythrocyte aggregation index (AI) (72.758 ± 7.65 vs. 66.483 ± 6.63, p = .002) and PV measured at a shear rate of 375 s−1 (1.932 ± 0.225 vs. 1.725 ± 0.331, p = .019) were significantly higher in patients with CSX. When AI, RDW and erythrocyte deformability measured at 1.69 Pa were evaluated together, it was observed that the increase in AI and RDW augments the risk of having CSX (OR: 1.2 and 2.65, respectively), while the rise in deformability decreases this risk (OR = 0.02). Conclusions: Hemorheological impairments are associated with CSX.


International Journal of Rehabilitation Research | 2015

Limitation of motion and shoulder disabilities in patients with cardiac implantable electronic devices

Gulin Findikoglu; Bekir Serhat Yildiz; Musa Sanlialp; Yusuf Izzettin Alihanoglu; Ismail Dogu Kilic; Harun Evregul; Hande Senol

The aim of this study is to investigate the presence of limitations in the shoulder range of motion (ROM) or the loss of upper extremity function on the affected side in patients with cardiac implantable electronic devices (CIEDs) with respect to the implantation time. Forty-nine patients (30 men and 19 women), mean age 64.84±11.18 years, who had been living with a CIED for less than 3 months were included in the short-term recipient (STR) group and 127 patients (85 men and 42 women), mean age 64.91±14.70 years, and with the device for longer than 3 months were included in the long-term recipients group. Shoulder ROMs were measured using a digital goniometer. The other arm was used as the control. The Constant–Murler Score, Shoulder Pain Disability Index, and Shoulder Disability Questionnaire were used to assess the functional status. Limitations of ROM for flexion, abduction, and internal rotation were found to be significantly lower in the arm on the side of CIED compared with the control arm. Significant differences in shoulder flexion, abduction, and external rotation in STRs were found compared with long-term recipient (P<0.05). However, the functional comparison of groups by the Constant–Murler Score was not significant. A low to moderate amount of shoulder disability measured by Shoulder Pain Disability Index and Shoulder Disability Questionnaire was found in patients with CIEDs, which was more prominent in STRs (P<0.05). Pain, association of CIED with pectoral muscles, a possible subtle ongoing capsular pathology, and avoidance behaviors of patients to minimize the risk of lead dislodgement might be related to restriction of motion and function in the shoulder joint in patients with CIEDs.


Clinical Hemorheology and Microcirculation | 2015

Investigation of hemorheological parameters at the diagnosis and follow up of children with iron deficiency anemia and mixed anemia

Yasemin Isik-Balci; Hazal Tancer-Elci; Melek Bor-Kucukatay; Ozgen Kilic-Erkek; Emine Kilic-Toprak; Hande Senol; Simin Rota

OBJECTIVE We aimed to investigate the effects of iron deficiency anemia (IDA) and vitamin B12 deficiency coexisting with IDA which is called as mixed anemia (MA) on hemorheological parameters, to compare them with each other and healthy controls, and to assess the changes in hemorheological parameters after treatment. MATERIALS AND METHODS 32 IDA patients (mean age:6.3 ± 5.3 years), 30 MA patients (mean age:7.2 ± 5.4 years), and 31 healthy controls (mean age:7.1 ± 5.2 years) were enrolled. Erythrocyte deformability and aggregation were determined by an ectacytometer, plasma and whole blood viscosities by a cone-plate rotational viscometer. Differences between IDA and MA, and healthy controls were compared. Hemorheological parameters were repeated in the patient groups after treatment and compared with the initial results. RESULTS In both of the patient groups, erythrocyte deformability, whole blood and plasma viscosities were found to be significantly decreased before treatment, compared with the controls. After treatment these parameters were found to be increased significantly. There were no significant differences in these parameters between the IDA and MA group. Additionally, no statistically significant alteration was found in erythrocyte aggregation measurements of both patient groups. CONCLUSION This study indicates that IDA and MA have similar effects on hemorheological parameters. When vitamin B12 deficiency accompanies IDA which is called as MA, no further alterations occur in hemorheological parameters. The adequate treatment of these anemias not only corrects the hematological parameters, but also by helping to normalize the hemorheological parameters, may contribute to the regulation of microvascular perfusion.


Rehabilitation Research and Practice | 2018

How Do Patients Understand Safety for Cardiac Implantable Devices? Importance of Postintervention Education

Bekir Serhat Yildiz; Gulin Findikoglu; Yusuf Izzettin Alihanoglu; Ismail Dogu Kilic; Harun Evrengul; Hande Senol

Aim This study was designed to assess the effect of patient education on the knowledge of safety and awareness about living with cardiac implantable electronic devices (CIEDs) within the context of phase I cardiac rehabilitation. Methods The study was conducted with 28 newly implanted CIED patients who were included in “education group (EG)”. Patients were questioned with a survey about living with CIEDs and electromagnetic interference (EMI) before and 1 month after an extensive constructed interview. Ninety-three patients who had been living with CIEDs were included in the “without education group (woEG)”. Results Patients in EG had improved awareness on topics related to physical and daily life activities including work, driving, sports and sexual activities, EMI of household items, harmful equipment, and some of the medical devices in the hospital setting (p<0.05). Patients in EG gave significantly different percent of correct answers for doing exercise or sports, using the arm on the side of CIEDs, EMI of some of the household appliances, medical devices, and all of the harmful equipment compared to woEG (p<0.05). Conclusion It was demonstrated that a constructed education interview on safety of CIEDs and living with these devices within the context of phase I cardiac rehabilitation is important for improving the awareness of patients significantly. Thus, patients might achieve a faster adaptation to daily life and decrease disinformation and misperceptions and thus promote the quality of life after the device implantation.


Heart Lung and Circulation | 2018

Impaired Blood Rheology in Pulmonary Arterial Hypertension

Yalin Tolga Yaylali; Emine Kilic-Toprak; Yasin Ozdemir; Hande Senol; Melek Bor-Kucukatay

BACKGROUND Understanding of the pathophysiologic manifestations of pulmonary arterial hypertension (PAH) is still evolving. The aims of the present study were to determine the alterations in blood rheology, and to investigate the relationship between those alterations and laboratory parameters in PAH. METHODS The study included 21 consecutive treatment-naive patients with PAH and 32 age and sex-matched healthy controls. Patients were categorised in class II (n=6), class III (n=13), and class IV (n=2). All subjects underwent right-heart catheterisation. Erythrocyte deformability and aggregation were measured by an ektacytometer. RESULTS Haemodynamic variables were as follows: the mean right atrial pressure: 9.94±5.76mmHg; the average pulmonary vascular resistance: 5.66±3 WU; Fick cardiac index: 4.15±2.75l/min/m2; and mixed venous O2 saturation: 64.59±12.53%. The average 6-minute walk distance was 351.09±133.08m. Erythrocyte deformability measured at 0.95, 3.00, and 5.33Pa was significantly lower, erythrocyte aggregation index (AI) was higher, and aggregation half-time (t1/2) was lower in PAH. AI and fibrinogen were positively correlated with NT pro-BNP (AI-NT pro-BNP: r=0.579; fibrinogen-NT pro-BNP: r=0.591). t1/2 was negatively correlated with NT pro-BNP (t1/2-NT pro-BNP: r=-0.648). CONCLUSIONS The increase in erythrocyte aggregation and the decrease in deformability may theoretically increase the flow resistance and may be of haemodynamic significance. The association between erythrocyte aggregation and NT pro-BNP may indicate that erythrocyte aggregation increases with disease progression. These alterations contribute to the understanding of the pathophysiology and could serve as markers of disease presence.


Forensic Science Medicine and Pathology | 2018

Sex determination with morphological characteristics of the skull by using 3D modeling techniques in computerized tomography

Ayşe Kurtuluş Dereli; Volkan Zeybek; Ergin Sagtas; Hande Senol; Hakan Abdullah Ozgul; Kemalettin Acar

Sex determination is a major area of investigation in forensic anthropology. As technology has advanced, imaging methods such as computed tomography and magnetic resonance imaging are being investigated as alternatives to conventional forensic anthropological research techniques. This study aimed to investigate the suitability of three-dimensional (3D) modeling of volumetric cranial computed tomography (CCT) images for sex estimation from skull morphology. In this study, CCT angiography images from the Department of Radiology 2017 archives were used retrospectively, and 3D images were obtained after the reconstruction of 85 cases of CCT images. The sex-dependent morphological characteristics of the skull were evaluated by three blinded observers and scored on a scale of 1–5 points according to the “Standards for Data Collection from Human Skeletal Remains”. The accurate sex estimation rates of the first, second and third observers were 91.8, 92.9 and 92.9%, respectively. The rate of accurate sex estimation for males was 98–100%, while this rate varied between 83.3–86.1% for females. Consistency in sex estimation between the three observers was 83.5%, with a Kappa value of 0.763 (z = 12.2; p = 0.0001*). The glabella was the most effective morphological trait used to estimate sex. The results of this study show that sex can be estimated from morphological features in volume-rendered CCT 3D images. Thus, sex can be estimated by digital images without the need for maceration processes, and the transfer of digital data in place of physical material will make it possible to gain expert opinions in forensic anthropology.


Arquivos Brasileiros De Cardiologia | 2016

Atrial Function in Patients with Breast Cancer After Treatment with Anthracyclines

Yalin Tolga Yaylali; Ahmet Saricopur; Mustafa Yurtdas; Hande Senol; Gamze Gokoz-Dogu

Background Atrial electromechanical delay (EMD) is used to predict atrial fibrillation, measured by echocardiography. Objectives The aim of this study was to assess atrial EMD and mechanical function after anthracycline-containing chemotherapy. Methods Fifty-three patients with breast cancer (48 ± 8 years old) who received 240 mg/m2of Adriamycin, 2400 mg/m2 of cyclophosphamide, and 960 mg/m2 of paclitaxel were included in this retrospective study, as were 42 healthy subjects (47 ± 9 years old). Echocardiographic measurements were performed 11 ± 7 months (median 9 months) after treatment with anthracyclines. Results Left intra-atrial EMD (11.4 ± 6.0 vs. 8.1 ± 4.9, p=0.008) and inter-atrial EMD (19.7 ± 7.4 vs. 14.7 ± 6.5, p=0.001) were prolonged; LA passive emptying volume and fraction were decreased (p=0.0001 and p=0.0001); LA active emptying volume and fraction were increased (p=0.0001 and p=0.0001); Mitral A velocity (0.8 ± 0.2 vs. 0.6 ± 0.2, p=0.0001) and mitral E-wave deceleration time (201.2 ± 35.6 vs. 163.7 ± 21.8, p=0.0001) were increased; Mitral E/A ratio (1.0 ± 0.3 vs. 1.3 ± 0.3, p=0.0001) and mitral Em (0.09 ± 0.03 vs. 0.11 ± 0.03, p=0.001) were decreased; Mitral Am (0.11 ± 0.02 vs. 0.09 ± 0.02, p=0.0001) and mitral E/Em ratio (8.8 ± 3.2 vs. 7.6 ± 2.6, p=0.017) were increased in the patients. Conclusions In patients with breast cancer after anthracycline therapy: Left intra-atrial, inter-atrial electromechanical intervals were prolonged. Diastolic function was impaired. Impaired left ventricular relaxation and left atrial electrical conduction could be contributing to the development of atrial arrhythmias.

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