Handong Yin

Synthesis and crystal structure of a novel pentanuclear complex of tin (IV) with heterocyclic sulfur and nitrogen donor ligands

Abstract A novel macrocyclic complex of organotin was synthesized by the reaction of dibutyltin dichloride with 2,5-dimercapto-1,3,4-thiodiazole. The title pentanuclear complex of tin is a 35-membered macrocycle. All five Sn atoms are six-coordinate, and have distorted octahedron geometries due to intramolecular Sn–N interactions. The title complex is characterized by Elemental analysis, IR, 1 H-NMR spectroscopy and X-ray diffraction.

Synthesis, structural characterization and in vitro cytotoxicity of diorganotin (IV) diimido complexes

Reactions of the diorganotin with two N-OH diimide ligands (N-hydroxyphthalimide and N-hydroxysuccinimide) yielded five new dimeric tetraorganostannoxanes formulated as R(8)Sn(4)O(2)L(2)X(2). The crystal structures of the complexes reveal the formation of the tetranuclear species contains a planar Sn(4)O(4) core, consisting of three adjacent rhombs with bridging oxo and N-OH diimide ligands. The central tin atoms are five-coordinated to assume a distorted trigonal bipyramidal configuration and the N-OH diimide ligands act as monodentate O-bound planar. In vitro cytotoxic activities of the title compounds have been determined against three cell lines (A549, HCT-8 and HL-60). Studies reveal that three di-n-butyltin(IV) diimido complexes show higher cytotoxic activities than cisplatin. The structure-activity relationship of the cytotoxicity of the title complexes has also been discussed.

Synthesis and crystal structure of two new Bi(III) complexes {(Me2NCS2)3Bi}2 and {[(CH2)5NCS2]2BiI}2

Six bismuth(III) complexes containing dithio-ligands formulated as (R2NCS2)3Bi [R2NCS2M = Me2NCS2Na, C4H8NCS2Na, Bz2NCS2Na] and [(R2NCS2)2BiI]2 [R2NCS2M = C5H10NCS2Na, n Bu2NCS2Na, OC4H8NCS2Na] have been obtained by reactions of bismuth(III) halides with dithiocarbamate ligands in 1 : 2 or 1 : 3 stoichiometry. All compounds were characterized by elemental and IR analyses. The crystal structures of complexes 1 and 4 have been determined by X-ray single crystal diffraction. The structure analyses reveal that BiIII in complex 1 adopts a distorted pentagonal–pyramidal coordination, due to its stereochemically active lone pair of electrons. A long Bi · S contact of 3.218 (3) Å leads to dimeric associations of molecules in the crystal structure. The structure of complex 4 is six-coordination with a distorted octahedral configuration. Intramolecular S · S weak interactions contribute to the stability and lead to a one-dimensional chain structure.

N′-[(E)-3-Pyridylmethyl­idene]benzo­hydrazide

The title compound, C13H11N3O, was prepared by the reaction of benzohydrazide and nicotinaldehyde. The dihedral angle between the planes of the two aromatic rings is 47.78 (9)°. The crystal structure is stabilized by intermolecular N—H⋯N hydrogen-bonding interactions.

Bis(2-hydroxy­benzaldehyde oximato-κO)triphenyl­anti­mony(V)

The molecule of the title compound, [Sb(C6H5)3(C7H6NO2)2], is located on a twofold axis defined by the metal center and two C atoms of a coordinated phenyl group. The Sb center has a slightly distorted trigonal-bipyramidal geometry, with the axial positions occupied by the O atoms of symmetry-related 2-hydroxybenzaldehyde oximate ligands. An intramolecular O—H⋯N interaction is present. The crystal structure is stabilized by C—H⋯O interactions.

μ-Oxido-bis­[(2-chloro­nicotinato-κO)triphenyl­anti­mony(V)]

A new dinuclear triphenylantimony(V) derivative with an oxide bridge, [Sb2(C6H5)6(C6H3ClNO2)2O], has been synthesized. Each Sb atom is five-coordianted by three C atoms and two O atoms in a distorted trigonal-bipyramidal geometry. Metal centers are bridged by a μ2-oxide functionality, and phenyl substituents on Sb atoms are in an staggered arrangement. The Sb—O—Sb bridge displays a bent geometry with an angle of 165.1 (4)°. Molecules interact in the crystal through weak C—H⋯O and C—H⋯N intermolecular hydrogen bonds.

Chlorido(2-chloro-nicotinato)triphenyl-anti-mony(V).

In the title complex, [Sb(C6H5)3(C6H3ClNO2)Cl], the Sb center has a close to ideal trigonal-bipyramidal geometry, with the phenyl ligands in equatorial positions and the chloride and a carboxylate O atom in axial positions. Weak C—H⋯O contacts generate dimeric units via crystallographic inversion centres.

Synthesis, crystal structure, and bioactivity of two triphenylantimony derivatives with benzohydroxamic acid and N-phenylbenzohydroxamic acid

Reaction of triphenylantimony dichloride with benzohydroxamic acid or N-phenylbenzohydroxamic acid in 1 : 1 stoichiometry yielded two new triphenylantimony derivatives formulated as [Ph3SbL1L2] (L1 = benzohydroxamato, L2 = methoxide, 1; L1 = N-phenylbenzohydroxamato, L2 = Cl, 2), which have been characterized by FT-IR, NMR spectroscopy, elemental analysis, and melting point. Single-crystal X-ray diffraction analyses for 1 and 2 reveal that the antimony is six-coordinate adopting distorted octahedral geometry with one phenyl and methoxide or chloride in axial positions. In the supramolecular structure, a double-chain is shown for 2 constructed by C–H ··· X (X = O, C or π) weak interactions, while 1 exhibits a 1-D-chain structure connected by O–H ··· O and N–H ··· N hydrogen bonds. In vitro antitumor study reveals that 1 and 2 display activities against two human tumor cell lines – A549 and HCT-8. To explore the antitumor activity mechanism, DNA binding properties of 1 and 2 with calf thymus DNA (ct-DNA) have been investigated by fluorescence spectra, indicating that 1 and 2 bind to ct-DNA via intercalation, which could induce the death of cancer cells.

Di-μ-hydroxido-bis­[aqua­trichlorido­tin(IV)] diethyl ether disolvate

The title compound, [Sn2Cl6(OH)2(H2O)2]·2C4H10O, consists of a centrosymmetric molecule and two additional solvent molecules and has an infinite two-dimensional network extending parallel to (101). The Sn atom is six-coordinate with a distorted octahedral geometry. Additional O—H⋯O hydrogen bonding leads to stabilization of the crystal structure.

Synthesis and crystal structure of diorganotin(IV) complexes with pyruvic acid benzoylhydrazone and pyruvic acid salicylhydrazone

Six diorganotin esters of Schiff-base ligands formulated as [R2SnLY]2, where L1 is C6H5CON2C(CH3)CO2 with Y = CH3CH2OH, R = mClC6H4CH2 (1), oFC6H4CH2 (2), pFC6H4CH2 (3) and L2 is 2-HOC6H4CON2C(CH3)CO2 with Y = CH3OH, R = oFC6H4CH2 (4), pFC6H4CH2 (5), mClC6H4CH2 (6) have been prepared and characterized by elemental analysis, IR, 1H and 119Sn NMR spectra. The crystal structures of complexes 1 and 4 have been determined by X-ray single crystal diffraction. The structure analyses reveal that the Sn atom in both 1 and 4 is seven-coordinate in distorted pentagonal bipyramid geometries with a planar SnO4N unit and two apical aryl carbon atoms, thus forming a dimeric molecule, which sits on a crystallographic center of symmetry. Intramolecular or intradimeric hydrogen bonds contribute to the stability and compactness of the crystal structures.