Hans Friede

A Follow-Up Study of Cleft Children Treated with Primary Bone Grafting: I. Orthodontic Aspects

The effect of primary bone grafting in the treatment of complete clefts has been studied with roentgenologic and biometric methods. The material, operated on during 1958–64, consisted of 16 patients with complete bilateral cleft lip and palate and 37 cases with complete unilateral cleft lip and palate. All of the studied bone grafts (= 69) healed well, but this did not lead to the expected normalisation of the growth of the middle face. On the contrary, our patients developed a pronounced maxillary retrognathia, which seemed to increase with age. This resulted in a concave facial skeletal profile for both the bilateral and unilateral cases. The occlusal analysis also indicated a maxillary growth retardation. Thus, our patients revealed a much higher frequency of anterior as well as lateral crossbites, when compared with other studies on not-bone-grafted clefts. Also, our patients had increased frequency of Class III molar relations while fewer had Class I and Class II relations. The growth aberration in m...

A FOLLOW-UP STUDY OF CLEFT LIP AND PALATE PATIENTS TREATED WITH ORTHODONTICS, SECONDARY BONE GRAFTING, AND PROSTHETIC REHABILITATION

The purpose of this study was to evaluate the significance of secondary bone grafting in cleft palate treatment. The investigation included a clinical, a biometrical, and a radiographic follow-up of the occlusion, the craniofacial morphology and the function of the masticatory system. The total material of secondary bone grafting cases during the period of 1958–68 consisted of 125 patients. For the final examination, 93 of them were present. The treatment plan was: (1) orthodontic treatment, (2) bone grafting, (3) retention treatment, (4) prosthetic reconstruction of lost teeth. 58 bridges were inserted. The mean age of the patients at the time of bone grafting was 20 years and the mean lag between the bone grafting procedure and the final check-up was 7 1/2 years. Besides bone grafting, 43 palatopharyngeal flap-operations were carried out. At the final check-up, none of the patients wear any obturator. Besides these operations 7 osteotomies of the lower jaw were carried out. The frequence of crossbites w...

Analysis of Dental Arch Relationships in Swedish Unilateral Cleft Lip and Palate Subjects: 20-Year Longitudinal Consecutive Series Treated With Delayed Hard Palate Closure

Objective: To evaluate the dental arch relationships for a consecutive series from Goteborg, Sweden, who had delayed hard palate closure. Design: Retrospective study. Setting: Sahlgrenska University Hospital, Goteborg, Sweden. Patients: The dental study models of 104 consecutive unilateral cleft lip and palate subjects. The study cohort was born between 1979 and 1994. Longitudinal records were available at ages 5 (n = 94), 10 (n = 97), 16 (n = 59), and 19 years (n = 46). Five assessors rated models according to the GOSLON Yardstick on two separate occasions each. Interventions: These patients had been operated upon according to the Goteborg protocol of delayed hard palate closure (at age 8 years). Results: 85% of subjects were rated in groups 1 and 2 (excellent or very good outcome), 12% were rated in group 3 (satisfactory), and 3% were assigned to group 4 (poor). No patients presented in Group 5 (very poor). Weighted kappa statistics for double determination of Yardstick allocation for five assessors demonstrated values between .65 and .90 for interrater agreement (good/very good) and between .70 and .90 for intrarater agreement (very good). Conclusions: Delayed hard palate closure as practiced in Goteborg since 1979 has produced the best GOSLON Yardstick ratings in a consecutive series of patients ever recorded worldwide, since the Yardstick was first used in 1983. However, it is noteworthy that a new protocol has been introduced in Goteborg since 1994, in which hard palate closure is done at 3 years due to concerns regarding speech.

Normal development and growth of the human neurocranium and cranial base.

The literature on normal development and growth of certain areas of the human head is reviewed, starting with the early induction of the desmal neurocranium. the development of the brain capsule with its dural reinforcement bands and their connection with the basicranium is discussed, as is the primordial chondrocranium, including its bone replacement. Growth of the calvaria and the three cranial fossae is also analysed. Special interest is focused on the anterior fossa, as knowledge of the growth in this area is very important for an understanding of pathogenesis and possibilities of treating premature craniosynostosis. Finally it is stressed that close observation of the effects of treatment on this pathology may increase our knowledge of normal growth.

Bone Grafting At The Stage Of Mixed Dentition In Cleft Lip and Palate Patients

Our results of bone grafting to the alveolar process during the mixed dentition were investigated in 55 consecutively treated patients (66 clefts). The amount of remaining bone and gingival retraction at the tooth mesial to the cleft after 3 and 12 months was measured and correlated with the following anatomical conditions present during surgery: width of the cleft, rotation of the adjacent incisor, stage of eruption of the tooth distal to the cleft. It was also considered if any deciduous lateral incisor or canine was extracted during surgery and if any flap dehiscence took place postoperatively. It was found that flap dehiscence resulted in significantly less bone at 3 months and at 1 year after surgery. Furthermore, extraction of a deciduous tooth was found to be significantly correlated to less bone 1 year after surgery, in which cases there were also persisting gingival retractions. The other factors had no significant influence on the outcome of surgery.

Craniofacial and occlusal characteristics in unilateral cleft lip and palate patients from four scandinavian centres

Craniofacial morphology and dental occlusion were studied at early school age in 15 consecutive patients with unilateral cleft lip and palate from each of four Scandinavian cleft centres. Treatment differed mainly in the techniques of palatal repair. Push-back closure of the palate particularly impaired maxillary development, which resulted in an increased incidence of crossbite and reduced intercanine distance when compared with patients who had been operated on by the von Langenbeck method or in whom the anterior palate had not yet been closed.

SPRING-MEDIATED CRANIOPLASTY COMPARED WITH THE MODIFIED PI-PLASTY FOR SAGITTAL SYNOSTOSIS

The aim of this study was to compare the safety, morphological outcome, and degree of parental satisfaction of the new spring-mediated cranioplasty with those of the modified pi-plasty in the management of sagittal synostosis. Ten patients with non-syndromic sagittal synostosis treated with the spring-mediated cranioplasty were followed prospectively. A control group of 10 sex-matched patients operated on with the modified pi-plasty procedure was chosen. Cephalometric radiographs were obtained preoperatively and postoperatively at 1 year of age. Cephalic index, axial width ratio, length ratio, width ratio and height ratio were used as objective measures of outcome. Parents were sent a questionnaire to obtain a subjective aesthetic assessment of outcome. Significantly less blood replacement was required (p = 0.003), and shorter duration of postoperative anaesthesia (p = 0.030) and postoperative hospital stay (p = 0.013) were found in the spring-mediated cranioplasty group. There were no complications or deaths in either group. Also significant was the inter-group difference in the postoperative change in the height ratio (p = 0.030), the most change being seen in the spring group. The change in the subjective parental aesthetic evaluation of skull shape was significant in both groups. In conclusion, the spring-mediated procedure was morphologically more effective than the modified pi-plasty procedure in the management of sagittal synostosis with the additional benefits of less blood transfusion needed and shorter duration of hospital stay.

Adolescent Facial Morphology of Early Bone-Grafted Cleft Lip and Palate Patients

A final evaluation of the effect of early bone grafting (EBG) on facial growth was carried out. The sample included 19 bilateral and 42 unilateral cleft lip and palate patients with an age range of 15-20 years, which meant on average 16 years after the EBG procedure. Roentgencephalometric data indicated maxillary retrognathia in both cleft categories and also deficient vertical descent of the maxilla, especially in the anterior part. In about 40% of the bilateral and 50% of the unilateral cleft patients, the mid-facial growth attenuation had reached such magnitude that surgical advancement of the maxilla was necessary. Analysis of plaster casts revealed that in every second cleft area the EBG operation had made it possible to achieve continuity in the dental arch without the need for prosthodontic replacement of teeth. Fusion of the suture between the (pre)maxilla and vomer was suggested as the reason for the typical mid-facial morphology seen in our patients with the most pronounced growth impairment.

Combined Bone Grafting and Delayed Closure of the Hard Palate in Patients with Unilateral Cleft Lip and Palate: Facilitation of Lateral Incisor Eruption and Evaluation of Indicators for Timing of the Procedure

OBJECTIVE To compare outcomes of bone grafting performed before eruption of the lateral incisor to outcomes of grafting performed before eruption of the canine and to evaluate the long-term results of bone grafting combined with delayed closure of the hard palate during mixed dentition. DESIGN Seventy consecutive patients (52 men and 18 women) with complete unilateral cleft lip and palate were studied. All patients underwent bone grafting with simultaneous closure of the cleft in the hard palate at the stage of mixed dentition. The velum had been repaired in infancy. Mean age for the bone grafting procedure was 8.4 years. Bone grafting was performed to facilitate eruption of the lateral incisor in 43 (61%) of the patients and to facilitate eruption of the canine in the remaining 27 (39%) patients. Intraoral radiographs were used to evaluate the morphologic characteristics of the cleft and the stage of eruption of the permanent lateral incisor and canine before bone grafting. Mean follow-up time was 4.0 years (range, 1-10.1 years). RESULTS The mean time for the surgery, which included bone grafting and repair of the residual cleft in the hard palate, was 109 minutes, and the mean amount of bleeding was 121 ml. The rate of dehiscence in the flap covering the alveolar bone graft was 14%, and the rate of total failure of bone grafting was 3%. An oronasal fistula developed in the hard palate of 13% of patients, but the fistula was of sufficient size to serve as an indication for reoperation in only 6%. The postoperative alveolar bony height in the cleft area was more than 75% of the normal height in 94% of patients. Closure of the cleft space in the dental arch was performed or planned to be achieved orthodontically in 91% of patients. When bone grafting was performed to facilitate eruption of the lateral incisor, the cleft space was closed orthodontically in 100% of patients. The optimal indicator for timing of the bone grafting procedure from an orthodontic point of view was when the permanent lateral incisor or the canine close to the cleft was covered by a thin shell of bone (i.e., 7-9 years of age).

A Follow-up Study of Cleft Children Treated with Vomer Flap as Past of a Three-Stage Soft Tissue Surgical Procedure: Facial Morphology and Dental Occlusion

The development of the face and jaws in cleft patients, treated with a three-stage surgical procedure including a single layer vomer flap, was studied by analysing cephalometric radiographs and dental casts. The material consisted of 13 patients with complete bilateral cleft lip and palate and 50 cases with complete unilateral cleft lip and palate, operated on 1964--1970. At the follow-up the average patient in both cleft categories demonstrated a maxillary retrognathia and in the unilateral cleft sample also a facial skeletal profile straighter than normal, though not as pronounced as we had found in cases where the vomer flap procedure was accompanied by bone grafting. However, the mean profile for the bilateral as well as the unilateral cleft group was straighter than reported for patients subjected to neither vomer flap nor bone grafting. The occlusal findings confirmed the maxillary growth retardation and similarly placed the present patients at a level between the results of the other two types of surgical regimes. As a side-effect cleft-bridging bone was formed in some part of the hard palate in every second case, though without importance for facial development. In an effort to reduce the restricted mid-facial growth found in the present patients, we have changed our surgical technique and since 1975 excluded the use of vomer flaps.