Hansotto Reiber

Laboratory Diagnosis in Neurology

The timing of this well merited second edition of so roundly presented a history of the evolution in our understanding of muscular dystrophy could scarcely be bettered, coming as it does in close juxtaposition with the very real hope of potentially effective treatment by means of targeted modification of gene behaviour for the X-linked hypertrophic disorder. Alan and Marcia Emery have produced a soundly researched and most readable, scholarly and well illustrated account of the development of our insight into the clinical, pathological, genetic and molecular biological nature of muscular dystrophy. There is the particularly pleasing www.elsevier.com/locate/nmd Available online at www.sciencedirect.com

2 Blood–Brain Barrier and Blood–CSF Barrier Function

The restriction of free exchange of molecules and cells between the blood and the perivascular extracellular spaces is referred to as a “barrier.” Passage rates may vary greatly because of the different morphological structures, but all molecules, including the largest proteins, and entire cells can pass these structures, even the blood–brain barrier with its particularly tight intercellular junctions.