Hany E. Khalil

Amphipaniculosides A-D, triterpenoid glycosides, and amphipaniculoside E, an aliphatic alcohol glycoside from the leaves of Amphilophium paniculatum.

Four new triterpenoids; One oleanane-, one ursane- and two cycloartane-type triterpenoids, named amphipaniculosides A-D, in addition to one new aliphatic alcohol glycoside, named amphipaniculoside E, were isolated from the 1-BuOH fraction of the leaves of Amphilophium paniculatum (L.) Kunth., together with five known compounds, (+)-lyoniresinol 3α-O-β-D-glucopyranoside, (-)-lyoniresinol 3α-O-β-D-glucopyranoside, acteoside (verbascoside), isoacteoside (isoverbascoside), and luteolin 7-O-β-D-glucopyranoside. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments ((1)H, (13)C, DEPT, COSY, ROESY, HSQC, HMBC) in combination with HR-ESI-MS and by comparisons of their physical and spectroscopic data with literature values.

CHEMICAL CONSTITUENTS FROM THE LEAVES OF Ruellia tuberosa

, 557 (2002).1) Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi,Minami-ku, 734-8553, Hiroshima, Japan, fax: +81-82-257-5335, e-mail: hotsuka@hiroshima-u.ac.jp; 2) Department ofPharmacognosy, Faculty of Pharmacy, Minia University, 61519, Minia, Egypt. Published in

Chemical structures of constituents from the leaves of Polyscias balfouriana

A new pyrrolidine derivative, (5S)-hydroxyethyl 2-oxopyrrolidine-5-carboxylate (1), a new flavonol glycoside, tamaraxetin 3,7-di-O-α-l-rhamnopyranoside (2), and a new triterpene saponin, polyscioside A methyl ester (3), along with six known compounds (4–9) were isolated from the leaves of Polyscias balfouriana. Their chemical structures were elucidated on the basis of extensive spectroscopic analysis.

Pharmacotherapeutic evaluation of Parmentiera cereifera Seem. (Family Bignoniaceae) cultivated in Egypt on albino rats.

Aims: The current study evaluates different biological activities viz., anti-inflammatory, antihyperglycemic and gastroprotective of methanolic extracts (MEs) of different parts viz., [mixture of leaves & stems (1:3) (MLS13), flowers and stem barks] and different fractions of ME of MLS13 of Parmentiera cereifera Seem. Moreover, this study estimates LD50 of ME of MLS13. Place and Duration of Study: The study was carried out for nine months in 2012 in the Department of Pharmacology, Faculty of Medicine and Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Minia University, Minia, Egypt. Methodology: The different MEs of various parts such as MLS13, flowers and stem barks and the Original Research Article Abdel-Wahab et al.; EJMP, 8(1): 29-38, 2015; Article no.EJMP.2015.087 30 different fractions of ME of MLS13 of P. cereifera were used in the present study. The different pharmacological activities such as anti-inflammatory, anti-hyperglycemic, gastroprotective and LD50 were determined using animal models as described in standard methods. Results: In yeast-induced paw edema method, ME of MLS13 had the highest anti-inflammatory activity (***P<0.001). While, in carrageenan-induced paw edema method, the highest antiinflammatory activity (***P<0.001) was exhibited by ME of stem barks. Moreover, both ME of flowers (***P<0.001) and ethyl acetate (EtOAc) fraction (***P<0.01) exhibited significant antihyperglycemic activity in alloxan-induced diabetes method. Furthermore, in indomethacin-induced gastric ulcer method, the highest gastroprotective effect (***P<0.001) was demonstrated by the petroleum ether (pet. ether) fraction. Finally, there is no toxicity symptoms of ME of MLS13 of P. cereifera up to 5 gm/kg. Conclusion: The biological results revealed that P. cereifera may be used in the development of various pharmaceutical preparations viz., anti-infalammatory, anti-hypergycemic as well as gastroprotective drugs, due to its wide safety margin.