Haoyue Xiang

Synthesis of Functionalized Chromeno[2,3-b]pyrrol-4(1H)-ones by Silver-Catalyzed Cascade Reactions of Chromones/Thiochromones and Isocyanoacetates.

A novel and convenient approach to the synthesis of chromeno[2,3-b]pyrrol-4(1H)-ones has been developed. Furthermore, the method involves a facile silver-catalyzed cascade cyclization reaction including an intramolecular C-O bond formation. The silver salt acts as a key promoter.

Synthesis of Multisubstituted 2-Aminopyrroles/pyridines via Chemoselective Michael Addition/Intramolecular Cyclization Reaction

A facile and efficient synthetic strategy to construct polysubstituted 2-aminopyrroles/pyridines was developed via chemoselective Michael addition/intramolecular cyclization reaction under very mild conditions. It suggested that the chemoselectivity of the process could be controlled by the leaving ability of the halides.

Pot, atom and step economic synthesis: a diversity-oriented approach to construct 2-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones

A diversity-oriented approach to construct 2-heteroaryl-substituted pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one derivatives via copper-promoted two-step one pot reactions from chromenone derivatives has been developed. Pot, atom and step economy (PASE) were combined in these sequential reactions, and at least six bonds were formed in one pot. A number of drug-like small molecules were prepared quickly and efficiently.

Synthesis of substituted pyrroles using a silver-catalysed reaction between isocyanoacetates/benzyl isocyanides and chromones

A novel synthetic strategy to construct substituted-pyrroles has been developed using silver-catalysed reactions between isocyanides/benzyl isocyanides and chromones. These reactions proceed under mild conditions and yield polysubstituted pyrroles with efficient yields. The silver catalyst plays a key role in sequestering and activating the isocyano group and in sequential Michael addition and cyclization reactions.

Catalyst-free synthesis of benzofuran-fused pyrido[4,3-d]pyrimidines from 2-(2-hydroxyaryl)acetonitrile and 4,6-dichloropyrimidine-5-carbaldehyde through domino condensation reactions

A rapid, one-pot, catalyst-free approach to novel benzofuran-fused pyrido[4,3-d]pyrimidines with good antitumor activities via a cascade SNAr/cyclization/condensation reaction through 2-(2-hydroxyphenyl)acetonitriles and 4,6-dichloropyrimidine-5-carbaldehyde was developed.

C–H Trifluoromethylation of 2-Substituted/Unsubstituted Aminonaphthoquinones at Room Temperature with Bench-Stable (CF3SO2)2Zn: Synthesis and Antiproliferative Evaluation

A direct C-H trifluoromethylation of 2-amino-1,4-naphthoquinone analogues is described. This reaction proceeds under mild conditions at open atmosphere, providing a range of CF3-containing naphthoquinones with good yield and functional group compatibility. All synthetic compounds were screened for antiproliferative activity against three human cancer cell lines. Notably, some of those trifluoromethyl analogs, such as 3a, 3g, 3j, and 3t, showed good antiproliferative profiles.

Cascade synthesis of novel functionalized pyridine-fused coumarins in aqueous medium

A simple, convenient and efficient catalyst-free approach for synthesis of a novel series of functionalized pyridine-fused coumarins via a cascade reaction from chromone derivatives in an environmentally friendly aqueous medium has been developed. This cascade reaction involves a chemoselective Michael addition–heterocyclization-intramolecular cyclization sequence.

Characteristics and reactivities of cobalt based mesoporous silica catalysts for fischer-tropsch synthesis

Abstract Performance in Fischer-Tropsch synthesis (FTS) and characteristics were investigated using Co-based HMS, MSU-1, and SBA-12 mesoporous silica catalysts. Due to the surface compound resistant to reduction for Co/MSU-1 and Co/SBA-12 and the decreasing number of the active site for Co/HMS, Co/SBA-12, Co/MSU-1 respectively, FTS activities of the catalysts decreased for Co/HMS, Co/SBA-12, and Co/MSU-1 respectively, and Co/HMS showed the lowest methane selectivity about 8.0 (wt)%.