Harald Weinstabl
University of Toronto
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Publication
Featured researches published by Harald Weinstabl.
Angewandte Chemie | 2013
Harald Weinstabl; Marcel Suhartono; Zafar Qureshi; Mark Lautens
Lignans are a diverse class of plant-derived natural products belonging to the phytooestrogen family. They have long been used as herbal remedies for pain, rheumatoid arthritis, and warts.1 However, more recently, lignans exhibiting immunosuppressive activity, tumor growth inhibition, and anti-fungal properties have been used in disease therapy, such as the anticancer agent etoposide.2
Angewandte Chemie | 2014
David A. Petrone; Hyung Yoon; Harald Weinstabl; Mark Lautens
The use of Pd catalysis as a means to synthesize organic halides has recently received increased attention. Among the reported methods is the Pd-catalyzed carboiodination, which uses extremely bulky ligands to facilitate carbon-halogen reductive elimination from Pd(II) as the key catalytic step. When approaching substrates exhibiting low stereoselectivity, catalyst troubleshooting becomes difficult as there are few ligands known to promote the key reductive elimination. Herein, we present our finding that tertiary amines act as weakly coordinating ligands which significantly enhance diastereoselectivity in the Pd/QPhos-catalyzed carboiodination of chiral N-allyl carboxamides. This methodology allows efficient access to enantioenriched and densely functionalized dihydroisoquinolinones, and has been applied toward the asymmetric formal synthesis of (+)-corynoline.
Angewandte Chemie | 2014
Marcel Sickert; Harald Weinstabl; Brendan Peters; Xiao Hou; Mark Lautens
A palladium-catalyzed intermolecular cross-coupling of two aryl iodides is reported, giving polycyclic ring systems with a high level of convergence and efficiency.
Synfacts | 2013
Mark Lautens; Harald Weinstabl
Significance: A class of chiral Cp ligands with tuneable steric parameters is reported and used in the Rh(III)-catalyzed allylation of N-methoxybenzamides. The obtained yields are good and the enantioselectivities excellent. Comment: Cyclopentadienyl (Cp) ligands are among the most versatile and frequently used ligands to access robust and highly catalytically active transition-metal complexes. However, there are only a few chiral Cp ligands reported so far. OMe
European Journal of Organic Chemistry | 2014
Zafar Qureshi; Harald Weinstabl; Marcel Suhartono; Hongqiang Liu; Pierre Thesmar; Mark Lautens
Synfacts | 2013
Mark Lautens; Harald Weinstabl
Synfacts | 2013
Mark Lautens; Harald Weinstabl
Synfacts | 2013
Mark Lautens; Harald Weinstabl
Synfacts | 2013
Mark Lautens; Harald Weinstabl
Synfacts | 2013
Mark Lautens; Harald Weinstabl