Hardy Sundaram
Organon International
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Publication
Featured researches published by Hardy Sundaram.
Bioorganic & Medicinal Chemistry Letters | 2001
Andrew Cooke; Alison Anderson; Kirsteen Buchanan; Alan Byford; David K. Gemmell; Niall M. Hamilton; Petula McPhail; Susan Miller; Hardy Sundaram; Peter Vijn
Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents.
Bioorganic & Medicinal Chemistry Letters | 2003
D. Jonathan Bennett; Alison Anderson; Kirsteen Buchanan; Alan Byford; Andrew Cooke; David K. Gemmell; Niall M. Hamilton; Maurice S. Maidment; Petula McPhail; Donald Stevenson; Hardy Sundaram; Peter Vijn
A number of water soluble bis-amino-2,6-dimethoxyphenyl ester derivatives were found to exhibit improved anaesthetic activity in mice relative to propofol 1. Of the analogues disclosed, 44 was further profiled in rodents and found to be a superior agent to propofol for the induction and maintenance of anaesthesia.
Bioorganic & Medicinal Chemistry Letters | 2003
Andrew Cooke; Alison Anderson; Jonathan Bennett; Kirsteen Buchanan; David K. Gemmell; Niall M. Hamilton; Maurice S. Maidment; Petula McPhail; Donald Stevenson; Hardy Sundaram
A novel series of α-amino-acid phenolic ester derivatives containing sulphide, sulphoxide, sulphone, ester and amide side chains were prepared and shown to display potent intravenous anaesthetic activity.
Journal of Medicinal Chemistry | 2001
Wilson Caulfield; Iain T. Collie; Rachel S. Dickins; Ola Epemolu; Ross McGuire; David R. Hill; Gillian McVey; J. Richard Morphy; Zoran Rankovic; Hardy Sundaram
Journal of Medicinal Chemistry | 1997
Alison Anderson; Andrew C. Boyd; Alan Byford; Alexander Campbell; David K. Gemmell; Niall M. Hamilton; David R. Hill; Claire Hill-Venning; Jeremy J. Lambert; Maurice S. Maidment; Valerie May; Richard J. Marshall; John A. Peters; David C. Rees; Donald Stevenson; Hardy Sundaram
Journal of Medicinal Chemistry | 2000
Alison Anderson; Andrew C. Boyd; John K. Clark; Lee Fielding; David K. Gemmell; Niall M. Hamilton; Maurice S. Maidment; Valerie May; Ross McGuire; Petula McPhail; Francis H. Sansbury; Hardy Sundaram; Robert Taylor
Journal of Medicinal Chemistry | 2001
Alison Anderson; Delia Belelli; D. Jonathan Bennett; Kirsteen Buchanan; Anna Casula; Andrew Cooke; Helen Feilden; David K. Gemmell; Niall M. Hamilton; Edward J. Hutchinson; Jeremy J. Lambert; Maurice S. Maidment; Ross McGuire; Petula McPhail; Susan Miller; Anna-Lisa Muntoni; John A. Peters; Francis H. Sansbury; Donald Stevenson; Hardy Sundaram
Bioorganic & Medicinal Chemistry Letters | 2005
Ronald Palin; David R. Barn; John K. Clark; Jean Cottney; Phillip M. Cowley; Marc Crockatt; Louise Evans; Helen Feilden; Richard R. Goodwin; Frank Griekspoor; Simon James Anthony Grove; Andrea K. Houghton; Philip S. Jones; Richard Morphy; Alasdair R.C. Smith; Hardy Sundaram; David Vrolijk; Mark A. Weston; Grant Wishart; Paul Wren
Bioorganic & Medicinal Chemistry Letters | 2004
Koc-Kan Ho; Kenneth C. Appell; John J. Baldwin; Adolph C. Bohnstedt; Guizhen Dong; Tao Guo; Robert A. Horlick; Khondaker R. Islam; Steven G. Kultgen; Christopher M. Masterson; Edward Mcdonald; Kirk McMillan; J.Richard Morphy; Zoran Rankovic; Hardy Sundaram; Maria L. Webb
Anesthesiology | 2000
David K. Gemmell; Alan Byford; Hardy Sundaram; Jeremy J. Lambert; Niall M. Hamilton
