Hargyan Singh

Synthesis of metal complexes of antimalarial drugs and in vitro evaluation of their activity against Plasmodium falciparum

Abstract Complexation behaviour of two well known anti- malarials, amodiaquine and primaquine, with VO(II), Cr(III), Fe(III), Cu(II), Co(II), Ni(II), Zn(II), Cd(II), Hg(II), Rh(III), Pd(II), Au(III), Ag(I), Mn(II), Sn(II) and Pt(II) has been studied. The corresponding complexes have been synthesized, characterised and screened by an in vitro microtechnique for their schizonticidal activity with a view to search for a more effective agent. The observed activities of the parent drugs and their metal complexes have been discussed to explain their mode of action.

In vitro evaluation of bacteriostatic activity of metal complexes of amodiaquine and primaquine

Abstract Aminoquinolines are effective antimalarial agents but have weak antibacterial activity. To study the effect of metal ions on the pharmacological behaviour of amodiaquine and primaquine - drugs derived from aminoquinolines - their complexes with 16 metal ions have been screened for their bacteriostatic activity against five human pathogenic bacterial strains. It has been found that complexes of soft acid metal ions are more effective antibacterial agents (lower MIC) than others.

Coordination Complexes of Drugs - Preparation and Characterisation of Metal Complexes of Amodiaquine - An Antimalarial Drug

Abstract Coordination compounds of VO(II), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), Ag(I), Au(III), Rh(III), Pd(II), Pt(II) and Sn(II) with amodiaquine-4-(7-chloro-4-quinolyl)amino-2-diethylamino-methylphenol-have been synthesized and characterized. Their magnetic moments, infrared and electronic spectra and thermal behaviour have been studied to establish their structure.

Synthesis and physicochemical studies of polymeric coordination complexes of some lanthanides with 1,4-dihydroxyanthraquinone

Abstract Coordination polymers of lanthanum(III), praseodymium(III), neodymium(III), samarium(III), dysprosium(III) and holmium(III) with 1,4-dihydroxyanthraquinone have been synthesized and characterised. Their magnetic moments, infrared spectra and electronic spectra have been studied to establish their structure. All the polychelates are amorphous, dark coloured powders, insoluble in common organic solvents and sparingly soluble in dimethylformamide. Nephelauxetic ratio (β), covalency factor ( b 1/2 ), etc. have been evaluated wherever possible. Thermogravimetric studies (TGA) indicate a higher decomposition temperature of polychelates than the parent ligand. A.c.-conductivity, dielectric constant (ϵ′), dielectric loss (ϵ″), all at various frequencies, as well as d.c.-conductivity of the prepared polychelates, are reported. The analytical data are suggestive of a 2:3 metal-ligand stoichiometry in the polychelates.

Hazards and analysis of thallium—A review

The most important sources of thallium pollution are gaseous emission from cement factories, coal burning power plants and metal smelters. Inhalation and consumption of home‐grown vegetables and fruits are the major routes of thallium intake. Absorption occurs in gastro‐intestinal tract followed by ingestion in respiratory tract caused by intratracheal infection. Highest concentration is attained in renal medulls of kidney. The normal dietary intake of adults has been estimated at ∼2 μg/day whereas average excretion of T1 is ∼ 1 μg/day. Thallium is excreted both in animal and men through kidney, intestine and in small parts via hair and milk. The concentration of thallium in urine and hair is taken as an indicator of internal exposure; permissible exposure limit is O.1 mgTl/m3. Once distribution is complete, thallium is slowly mobilized from its intracellular compartment with a total body half life of approximately 30 days. The determination of sub micro and micro‐gram quantities of thallium is described ...

Coordination Complexes of Drugs - Preparation and Characterization of Metal Complexes of Primaquine

Abstract Metal complexes of primaquine with VO(II), Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), Hg(II), Ag(I), Au(III), Rh(III), Pd(II), Pt(II) and Sn(II) have been prepared and characterized. IR spectral studies suggest that primaquine acts as a bidentate ligand.