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Dive into the research topics where Harold A. Abramson is active.

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Featured researches published by Harold A. Abramson.


Journal of Allergy | 1942

Skin reactions to electrophoretic fractions of timothy pollen extract

Harold A. Abramson; M.G. Engel; Dan H. Moore

Abstract 1.1. Timothy pollen extract has been fractionated electrophoretically. 2.2. As in the case of ragweed pollen extract, there is present a major, colorless, slow-moving component which is electrophoretically homogeneous at pH 7.4. 3.3. In addition, there are also present six or more negatively charged, pigmented components which migrate more rapidly than the colorless fraction. 4.4. On direct skin tests, the slow-moving, colorless component, the fast pigments, and the intermediate pigments showed about the same skin reactivity. 5.5. On passive transfer, both the pigments and the colorless fraction also showed positive reactions. 6.6. Preliminary data obtained by means of the ultracentrifuge and diffusion techniques indicate that all of the constituents under discussion are of small molecular size compared with ordinary proteins. 7.7. The diffusion rate of the colorless fraction of timothy is very close to the analogous component of ragweed. 8.8. Questions arising connected with the immunologic specificity of the various fractions are briefly discussed.


Journal of Allergy | 1942

Skin reactions: XV. Quantitative studies of whealing☆

Harold A. Abramson; M.G. Engel; H.H. Gettner

Abstract 1.1. A quantitative method of following semiquantitatively the volume of whealing liquid whether produced pharmacclogically or by external means is described. 2.2. The method makes use of the projection of the image of the displacement of square pencil leads on photographic paper against the actual base line of the wheal. By enlarging this image under standard conditions and cutting out and weighing the elevations, a measure of the whealing volume as represented by the elevated (contour) areas is obtained. 3.3. This technique has been applied to the quantitative study of whealing produced by histamine and the reaction of the skin to the injection of distilled water, epinephrine, histamine, and similar pharmacologically important materials. 4.4. It has been shown that two factors must be followed in the study of the disappearance of whealing liquid; namely, the redistribution of the liquid following its injection and absorption of the liquid. 5.5. The first factor will essentially depend upon the mechanical structure of the dermis. This is probably the basis for the rapid disappearance in edema.


Experimental Biology and Medicine | 1928

Orientation of Cylindroid Particles in Gelatin-Serum Gels.

Harold A. Abramson

The phenomenon here described has been observed during the study of the cataphoresis of red cells and rouleaux in gelatin-serum sols and gels. The method of preparation of the suspension has been described elsewhere. 1 The red cells of the horse, since they do not become coated with proteins in the manner of quartz particles when suspended in a soft gelatin-serum (2 to 3% gelatin) gel, have the remarkable property of migrating through a protein sol or gel. If cylindroids, consisting of red cells in rouleaux formation, are moved back and forth through such a sol or gel, by virtue of their cataphoretic mobility, no orientation of these cylindroid bodies occurs during the cataphoretic migration. At the same time the gelatin and serum protein micellae are also in movement, as well as the liquid in the cataphoresis cell. 2 As gelation proceeds, the speed of the cylindroid bodies becomes much slower. In spite of the fact that the cylindroids have been moved back and forth in the cell over a considerable period, i. e., 10 minutes, and even though they are apparently subjected to a laminary liquid stream, the orientation of the cylindroids is still at random with a tendency, however, to be placed in planes parallel to the horizontal plane of the cataphoresis cell. The current is now discontinued and gelation is permitted to proceed. After a considerable time interval (about 24 hours) during which the a stiff gel is formed, it is found that the cylindroid particles have been oriented so that their lengthwise axes are parallel to the lines of the current flow.∗ It is to be emphasized that the orientation takes place after the electric current has ceased to flow.


Experimental Biology and Medicine | 1924

Visualization of the gall bladder of the dog by the Roentgen ray.

Harold A. Abramson

By injecting solutions of sodium iodide or Neo-silvol (Parke-Davis) into the gall bladder of the dog, the movements of the gall bladder and the fate of contained fluids may be easily studied fluoroscopically and by radiograph. Neo-silvol, a silver-proteiniodide compound, is particularly useful because it is not readily absorbed and is relatively non-irritating. Excellent radiographs of the gall bladder have been obtained after direct injection of 1 cc. of a 35 per cent solution of sodium iodide. The volume of the gall bladder in a medium sized dog is greater than 21/2 cc. Much more of the salt may therefore be used, and isotonicity still be preserved since sodium iodide is isotonic at about a concentration of 141/2 per cent. Proportionate amounts of Neosilvol may similarly be used. The presence of pneumoperitoneum remaining postoperatively or induced experimentally, is a distinct aid in visualization where it is desirable to use small concentrations of material. The following observations have been made on six dogs while recovering from anesthesia, after anesthesia, or a number of days after operation. The total number of actual experimental hours of observation was between fifteen and twenty. 1. Spontaneous Expulsion. Only once during the course of this series was there seen spontaneous expulsion of material from the gall bladder. This was in a cholecystostomized dog (No. 3361, May 29, 1923) which five days after a small bored rubber tube had been placed in the gall bladder wall, was taken to fluoroscopy. Four cc. of 150 per cent sodium iodide was injected through the tube. The gall bladder became beautifully outlined. During the next ten minutes the dog was standing comfortably on the platform on four iegs, or occasionally sitting down, nothing was seen to enter the duct and go into the duodenum.


Experimental Biology and Medicine | 1921

The diffusion of sodium chloride through a “lecithin”-collodion membrane

Harold A. Abramson; Samuel H. Gray

Conclusions I. Changes in the drying time, to four minutes, of membranes prepared from collodion and fixed with water does not appreciably alter their permeability to sodium chloride, whereas membranes prepared under the same conditions containing fifty per cent. of “ Lecithin ” by weight become relatively semi-permeable with decreasing drying times. II. Changes in the sizes of the aggregates of the lecithin molecules is suggested as a possible influence on the permeability of the leci thin-collodion membranes.


Journal of Biological Chemistry | 1933

THE ISOELECTRIC POINT OF INSULIN ELECTRICAL PROPERTIES OF ADSORBED AND CRYSTALLINE INSULIN

Oskar Wintersteiner; Harold A. Abramson


Archives of Dermatology | 1941

SKIN REACTIONS: XII. PATTERNS PRODUCED IN THE SKIN BY ELECTROPHORESIS OF DYES

Harold A. Abramson; Margery G. Engel


Journal of Investigative Dermatology | 1938

Skin Reactions: II. The Effect of Allergic and Histamine Wheals on the Rate of Absorption of Dyes and Blood from the Human Cutis1

Harold A. Abramson; Margery G. Engel


Journal of Biological Chemistry | 1927

THE UTILIZATION OF INTRAVENOUS SODIUM r-LACTATE I. EXCRETION BY KIDNEYS AND INTESTINES

Harold A. Abramson; Philip Eggleton


Journal of Biological Chemistry | 1927

THE DIFFUSION OF WATER INTO LECITHIN-COLLODION MEMBRANES

Harold A. Abramson; Samuel H. Gray

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Dan H. Moore

California Pacific Medical Center

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