Harold L. Hirsh

THE TREATMENT OF ACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN

Excerpt Prior to the use of penicillin, the establishment of a diagnosis of acute bacterial endocarditis was tantamount to prophesying the patients death within one to six weeks. In the literature...

TOXIC REACTIONS ACCOMPANYING SECOND COURSES OF SULFONAMIDES IN PATIENTS DEVELOPING TOXIC REACTIONS DURING A PREVIOUS COURSE

Excerpt The sulfonamide drugs are so commonly administered at the present time that practically every person has received one of them on some occasion. Consequently, it is of importance to consider...

GONOCOCCAL ARTHRITIS: A STUDY OF 202 PATIENTS TREATED WITH PENICILLIN, SULFONAMIDES OR FEVER THERAPY

Excerpt Prior to March, 1932, only symptomatic measures were available for the treatment of gonococcal arthritis. At that time, it was observed during a course of fever therapy for syphilis that th...

Oral penicillin in the treatment of various bacterial infections

Abstract 1.1. Penicillin was administered by the oral route to 350 patients, and the results were compared with those obtained in over 600 patients treated by intermittent intramuscular injections. The oral doses were approximately five times as great as the parenteral doses. 2.2. The results were comparable to those obtained with parenteral therapy in the case of pneumonia, streptococcic sore throat, scarlet fever, erysipelas and otitis media. They were less satisfactory in Vincents stomatitis and poor in the case of bacterial endocarditis. 3.3. Hypersensitivity reactions were less frequent than with penicillin administered by the other commonly used routes.

Penicillin and sulfadiazine, compared with sulfadiazine alone, in the treatment of pneumococcic pneumonia.

Excerpt Until the discovery of penicillin, sulfadiazine and several of its analogues were recognized universally as the drugs of choice in the treatment of pneumococcic pneumonia. When penicillin w...

The effect of caronamide on the blood concentration of penicillin following oral and intramuscular administration of penicillin.

Excerpt One of the greatest problems in the clinical use of penicillin has been the maintenance of adequate plasma concentrations in spite of the rapid rate at which the antibiotic is excreted by t...