Harold Michelsen

Pure XX gonadal dysgenesis in identical twins

Pure gonadal dysgenesis has been described in several sibships. We report a pair of monozygous twins and their younger sister with secondary amenorrhea. They had no associated congenital anomalies. Plasma FSH levels were elevated and the ovarian biopsies showed absence of follicular structures. Their karyotypes were 46XX, further supporting the concept that this form of familial gonadal dysgenesis is an autosomal recessive defect.

Evaluación por inmunohistoquímica de la expresión de hormonas hipofisiarias y del marcador de proliferación celular Ki-67 en tejido de adenomas causantes de acromegalia

Forty one paraffin embedded surgical samples of pituitary adenomasfrom patients with acromegalia were studied. Immunohistochemistry for GH, prolactin (PRL),follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone(TSH), adrenocorticotropin (ACTH) and for the expression of Ki-67 was carried out.

Pure XX Gonadal Dysgenesis in Identical Twins

Pure gonadal dysgenesis has been described in several sibships. We report a pair of monozygous twins and their younger sister with secondary amenorrhea. They had no associated congenital anomalies. Plasma FSH levels were elevated and the ovarian biopsies showed absence of follicular structures. Their karyotypes were 46XX, further supporting the concept that his form of familial gonadal dysgenesis is an autosomal recessive defect.