Harold Weingarten

Cleavage site specificity of vertebrate collagenases.

A series of synthetic peptide substrates for vertebrate collagenase having the structure Ac-Pro-Leu-Gly-X-Leu-Gly-OC2H5, where X is Leu, Ile, Val, Phe and Ala, have been prepared. Collagenolytic enzymes from various sources cleave these substrates with differing relative rate patterns. This series of peptides should be valuable for characterization of collagenases.

Gas chromatographic analysis of Chlorinated Biphenyls

Abstract Capillary column gas chromatography is reported as an analytical method for biphenyl, the 3 monochlorobiphenyls and the 12 dichlorobiphenyls. Two complementary columns were used permitting, in effect, total resolution.

Organometallic Enamines and Imonium Salts from Enamines and Inorganic Halides

Abstract Enamines react with groups IV and V halides to form organometallic imonium type salts and organometallic enamines. This reaction is a potentially useful method of grafting organic functionality onto inorganic systems.

Functional Derivatives of Phosphorus: Preparation of OP(CH2COOH)3 and C6H5P(O) (CH2COOH)2 and their Amides

Abstract The preparation of OP(CH2COOH)3 and C6H5P(O) (CH2COOH)2 and their corresponding N,N-dimethylamides is described.

The Conversion of 1,3-Cyclooctadiene to 1-Vinylcyclohexene

Abstract The sensitized photolysis of cis-cis-1,3-cyclooctadiene yields bicyclo [4.2.0]octene-7 (1), efficiently and in good yield.1 We have found that 1 may be converted very simply into 1-vinylcyclohexene (3) 2 via bicyclo [4.2.0] octene-8 (2).

The reaction of enamines with inorganic halides

Enamines react with Group IV halides to form organometallic immonium type salts and organometallic enamines.