Harry L. Slates

Total synthesis of the macrolide, zearalenone.

Abstract Total synthesis of the biologically active macrolide zearalenone together with its optical resolution and the determination of its absolute configuration as “S” are described. Wittig condensation with an ortho aldehydic ester proceeded in part with vicinal interaction and formation of an acetylenic product.

A total synthesis of griseofulvin and its optical antipode

Abstract An efficient total synthesis of (+) griseofulvin and its optical antipode, (−) griseofulvin, is described. Several aspects of the chemistry of this substance, its precursors and transformation products are discussed.

A stereoselective total synthesis of (±) prostaglandin E11,2

Abstract A stereoselective total synthesis of prostaglandin E1 employing 5-methoxyindanone-1 as starting material is described.

A STEREOSELECTIVE TOTAL SYNTHESIS OF NAT(-)-PROSTAGLANDIN E(1) AND ITS OPTICAL ANTIPODE

Abstract A stereoselective total synthesis of nat (−) prostaglandin E 1 and its optical antipode employing the Diels-Alder adduct of trans -piperylene and maleic anhydride as starting material is described.