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Harumi Ogawa

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Publication

Featured researches published by Harumi Ogawa.

Bioorganic & Medicinal Chemistry | 2002

Halohydrin and oxime derivatives of radicicol: synthesis and antitumor activities.

Tsutomu Agatsuma; Harumi Ogawa; Kazuhito Akasaka; Akira Asai; Yoshinori Yamashita; Tamio Mizukami; Shiro Akinaga; Yutaka Saitoh

Novel halohydrin and oxime derivatives of radicicol (1) were prepared and evaluated for their v-src tyrosine kinase inhibitory, antiproliferative, and antitumor activities. Some of the resulting derivatives showed significantly improved antitumor activities than those of 1 in vitro as tested in a cell proliferation assay and in vivo using sc-inoculated human breast carcinoma and epidermoid tumor models. Design and synthesis of radicicol-based novel affinity probes are also described.

Organic Letters | 2002

UCS1025A and B, New Antitumor Antibiotics from the Fungus Acremonium Species

Tsutomu Agatsuma; Tsutomu Akama; Shinji Nara; Shigeki Matsumiya; Ryuichiro Nakai; Harumi Ogawa; Shizuo Otaki; Shun-ichi Ikeda; Yutaka Saitoh; Yutaka Kanda

Journal of Medicinal Chemistry | 2003

Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol.

Yoji Ikuina; Nobuyoshi Amishiro; Mayumi Miyata; Hiroaki Narumi; Harumi Ogawa; Tadakazu Akiyama; Yukimasa Shiotsu; Shiro Akinaga; Chikara Murakata

The Journal of Antibiotics | 2000

UCS1025A, a Novel Antibiotic Produced by Acremonium sp.

Ryuichiro Nakai; Harumi Ogawa; Akira Asai; Katsuhiko Ando; Tsutomu Agaisuma; Shigeki Maisumiya; Shiro Akinaga; Yoshinori Yamashita; Tamio Mizukami

Chemistry & Biology | 2006

Telomerase Inhibitors Identified by a Forward Chemical Genetics Approach Using a Yeast Strain with Shortened Telomere Length

Ryuichiro Nakai; Hiroyuki Ishida; Akira Asai; Harumi Ogawa; Yoshihiro Yamamoto; Hideki Kawasaki; Shiro Akinaga; Tamio Mizukami; Yoshinori Yamashita

The Journal of Antibiotics | 1998

UCH9, a New Antitumor Antibiotic Produced by Streptomyces: I. Producing Organism, Fermentation, Isolation and Biological Activities

Harumi Ogawa; Yoshinori Yamashita; Ritsuko Katahira; Shigeru Chiba; Toshiaki Iwasaki; Tadashi Ashizawa; Hirofumi Nakano

Nucleic Acids Research | 1998

Solution structure of the novel antitumor drug UCH9 complexed with d(TTGGCCAA)2 as determined by NMR

Ritsuko Katahira; Masato Katahira; Yoshinori Yamashita; Harumi Ogawa; Yoshimasa Kyogoku; Mayumi Yoshida

The Journal of Antibiotics | 1998

UCH9, a New Antitumor Antibiotic Produced by Streptomyces II. Structure Elucidation of UCH9 by Mass and NMR Spectroscopy

Ritsuko Katahira; Yoichi Uosaki; Harumi Ogawa; Yoshinori Yamashita; Hirofumi Nakano; Mayumi Yoshida

The Journal of Antibiotics | 2000

Pyrronamycin A and B, Novel Antitumor Antibiotics Containing Pyrrole-amide Repeating Unit, Produced by Streptomyces sp.

Akira Asai; Yasushi Sakai; Harumi Ogawa; Yoshinori Yamashita; Shingo Kakita; Keiko Ochiai; Tadashi Ashizawa; Akira Mihara; Tamio Mizukami; Hirofumi Nakano

Archive | 1997

DERIVADOS DE RADICICOL.

Shiro Akinaga; Tadakazu Akiyama; Nobuyoshi Amishiro; Yoji Ino; Mayumi Miyata; Chikara Murakata; Harumi Ogawa; Yukimasa Shiotsu; Shiroh Soga

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Collaboration

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Yoshinori Yamashita

Geron Corporation

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Shiro Akinaga

National Institutes of Health

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Ritsuko Katahira

Novartis

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Akira Asai

University of Shizuoka

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Hirofumi Nakano

Kyushu University

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Tamio Mizukami

Nagahama Institute of Bio-Science and Technology

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Chikara Murakata

Kyowa Hakko Kirin Co.

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Nobuyoshi Amishiro

Kyowa Hakko Kirin Co.

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Ryuichiro Nakai

Kyowa Hakko Kirin Co.

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Tadakazu Akiyama

Medical Research Council

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