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Dive into the research topics where Harun Karamanli is active.

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Featured researches published by Harun Karamanli.


Metabolic Syndrome and Related Disorders | 2011

Relationship Between Components of Metabolic Syndrome and Polysomnographic Findings in Obstructive Sleep Apnea

Duygu Ozol; Cansel Türkay; Benan Kasapoglu; Harun Karamanli; Zeki Yıldırım

AIMS Obstructive sleep apnea/hypopnea syndrome (OSAHS) and metabolic syndrome are both growing health concerns, owing to the worldwide obesity epidemic. This study evaluates the potential association between the parameters of metabolic syndrome and OSAHS. METHODS A total of 125 consecutive patients undergoing complete full night polysomnography were included. Insulin resistance (IR) was estimated using the homeostasis model assessment (HOMA), and metabolic syndrome was diagnosed according to the National Cholesterol Education Program (NCEP) criteria. RESULTS The prevalence of metabolic syndrome was 23.8% among patients with OSAHS. We found that IR, age, weight, hypertension, and metabolic syndrome prevalence increased significantly with severity of OSAHS. There were no differences between groups for lipid panels including total cholesterol, triglycerides, low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Subjects with metabolic syndrome had significantly lowest desaturation value (76% vs. 81%) desaturation (76% vs. 81%, P = 0.003), lower mean nocturnal oxygen saturation (89.9% vs. 92.3%, P < 0.00.1), higher apnea-hypopnea index (AHI) (40.9 vs. 17, P < 0.001), and higher oxygen desaturation index (38 vs. 17, P = 0.002). Lowest desaturation and mean nocturnal oxygen saturation were significantly lower in subjects with IR (76% vs. 85%, P = 0.004 and 90.4% vs. 93.0%, P = 0.02). In multivariate analysis, the percent of time below 90% saturation [%T < 90]) (P = 0.04) was independently associated with IR. CONCLUSIONS Our results suggested that metabolic syndrome prevalence increased with severity of OSAHS and vice versa. Nocturnal hypoxic episodes in OSAHS patients could be a risk factor for developing hypertension and IR.


Helicobacter | 2016

Increased Exhaled 8-Isoprostane and Interleukin-6 in Patients with Helicobacter pylori Infection.

Zeki Yildirim; Bülent Bozkurt; Duygu Ozol; Ferah Armutcu; Recep Akgedik; Harun Karamanli; Deniz Kizilirmak; Mustafa Ikizek

Helicobacter pylori (H. pylori) infection triggers both local inflammation, usually in gastric mucosa, and chronic systemic inflammation. It is assumed that this local and systemic inflammation is caused by extracellular products excreted by H. pylori. The aim of this study was to investigate the possible association between H. pylori infection and a local inflammatory response in the airway by using exhaled breath condensate technique.


Journal of Investigative Medicine | 2016

Influence of obstructive sleep apnea on ischemia-modified albumin levels and carotid intima-media thickness

Harun Karamanli; Aysel Kiyici; Bilal Arik; Duran Efe; Recep Akgedik

Obstructive sleep apnea (OSA) is associated with an increased risk of atherosclerosis. Carotid intima-media thickness (CIMT) is strongly associated with the presence of significant risk factors for cardiovascular disturbances. A disturbance in the oxidative/antioxidative balance is involved in the pathogenesis of OSA and cardiovascular diseases. Ischemia-modified albumin (IMA) is suggested as a novel marker of oxidative stress; IMA can be defined as decreased binding of transitional metal ions to serum albumin in oxidative status. The purpose of this research was to evaluate the influence of OSA on IMA levels and CIMT. In total, 61 individuals with OSA with no comorbidities and 24 healthy controls with a similar body mass index and age were enrolled in this study. Serum levels of IMA, CIMT (estimated radiologically), and polysomnographic parameters, were determined and interpreted. Serum IMA levels were significantly higher in individuals with OSA compared with the control group (p=0.0003). CIMT was significantly higher in the OSA group compared with the control group (0.88± 0.26 mm vs 0.75±0.17 mm, p=0.005). The CIMT and serum IMA levels were positively correlated with the apnea-hypopnea index (r=0.35 and r=0.32, respectively), and with the oxygen desaturation index (r=0.34 and r=0.29, respectively) at baseline. Increased IMA levels and CIMT may be related to increased oxidative stress and risk of atherosclerosis in individuals with OSA.


Clinical Respiratory Journal | 2018

Mounier-kuhn syndrome (tracheobronchomegaly): An analysis of eleven cases

Recep Akgedđk; Harun Karamanli; Deniz Kizilirmak; Ali Bekir Kurt; Hasan Öztürk; Berna Botan Yildirim; Lütfullah Çakir

Mounier‐Kuhn syndrome (MKS) is a congenital disorder characterized by tracheobronchomegaly resulting from the absence of elastic fibers in the trachea and main bronchi or atrophy and thinning of the smooth muscle layer. In this syndrome, dead space associated with tracheobronchomegaly increases and discharge of secretions decreases because of ineffective coughing. The most common complications are recurrent lower respiratory tract infections and bronchiectasis. We examined the clinical characteristics, radiological features, and related complications of patients with MKS.


Clinical Respiratory Journal | 2018

Swyer–James–Macleod syndrome mimicking an acute pulmonary embolism: A report of six adult cases and a retrospective analysis

Recep Akgedik; Harun Karamanli; Ilknur Aytekin; Ali Bekir Kurt; Hasan Öztürk; Canan Eren Dagli

In patients with pulmonary embolism (PE), a pulmonary radiograph may reveal oligemic fields (the Westermark sign) associated with sites of occlusion of the pulmonary arteries, interruption or loss of the artery line (the knuckle sign), and even unilateral hyperlucency attributable to reduced overall lung vascularity. In Swyer–James–Macleod syndrome (SJMS), which develops as a result of bronchiolitis obliterans, unilateral hyperlucency is evident because of emphysema and hypoplasia of the pulmonary artery and its branches. Therefore, SJMS cases with clinical and laboratory data compatible with PE may in fact be confused with PE. The cases of six adult patients who were initially presumed to have PE but on further investigation were diagnosed with SJMS are presented in this report, which thus can serve as a guide for diagnosis of similar cases in future.


Turkiye Klinikleri Journal of Internal Medicine | 2016

Relationship Between Obstructive Sleep Apnea and Increased Thoracic Periaortic Adipose Tissue

Ömer Akyürek; Harun Karamanli; Duran Efe

ABS TRACT Objective: Aim of this study is to demonstrate the increased thoracic periaortic adipose tissue volume which is related to increased cardiovascular risk in subjects with obstructive sleep apnea (OSA) compared to control group. Material and Methods: The study population consisted of 25 newly diagnosed OSA patients (mean (SD) age: 55.0 (±12.1) years, 64% were males) and 34 healthy volunteers (mean (SD) age: 53.2 (±11.8) years, 61.8% were males). Standard overnight polysomnography system had applied to all of the participant and apnea–hypopnea index (AHI) was calculated. In addition, all of the participants underwent thoracic radiographic assessment in the supine position, using an 8-slice multidetector computed tomography scanner and thoracic periaortic adipose tissue volume was measured. Control group and OSA group were compared according to demographic characteristics, anthropometrics measurements and laboratory findings. Results: In subjects with OSA, thoracic periaortic adipose tissue volume [50.3 (±14.9) cm3 vs. 19.6 (±8.4) cm3, p<0.001], apnea-hypopnea index (AHI) [19.9 (±9.5) vs. 2.7 (±1.1) p<0.001)], triglyceride [204.7 (±87.1) mg/dL vs. 145.1 (±40.2) mg/dL (p= 0.003)] and total cholesterol [204.7 (±39.6) mg/dL vs. 183.5 (±36.1) (p=0.041)] levels were significantly higher compared to the control group. While there was a positive correlation between thoracic periaortic adipose tissue and AHI, no correlation was found with the other parameters. In stepwise regression analysis, AHI emerged as a significant predictor of thoracic periaortic adipose tissue (r= 0.41, p= 0.038), contributing to 13.7% of its variability. In OSA subjects, no significant difference was noted in thoracic periaortic adipose tissue levels with respect to gender (p=0.72), total cholesterol (p= 0.53), triglyceride (p= 0.34), or smoking status (p=0, 32). Conclusion: Our findings indicate significantly higher values for thoracic periaortic adipose tissue in OSA than controls, being associated positively with dyslipidemia and strongly predicted by AHI levels in OSA subjects, while not differing with respect to gender, and smoking status.


Turkish Thoracic Journal | 2016

Depressive Symptoms in Patients with Obstructive Sleep Apnea

Harun Karamanli; Fatih Kayhan; Recep Akgedik

OBJECTIVES Different studies have investigate depressive symptom degree within sleep disordered patients with obstructive sleep apnea (OSA). However, little is known and unclear about OSA in patients with depression symptom in the literature. The purpose of this study was to investigate patients with OSA would have a higher prevalence of depression symptom relative to control patients. MATERIAL AND METHODS 72 patients with OSA (AHI ≥ 5) and 24 control subjects (AHI < 5) were assessed for depression symptom using the Beck Depression Inventory. Participants were underwent an overnight polysomnography assessment. An apnea-hypopnea index ≥ 5 events per hour was used as diagnosis for OSA. The associations between each total score on the Beck Depressive Inventory (BDI) and polysomnographic parameters were examined by correlation analysis. RESULTS We demonstrated that BDI scores has statistically significant correlation with the OSA in our present study according to similar previous studies (p= 0.008). Oxygen Desaturation Index (ODI) has correlated with BDI (r= 0.31). CONCLUSION These findings show that the frequency depression symptom is higher among individuals with OSA. Patients with OSA should be screened cautiously for depressive disorders.


Inflammation | 2012

Effect of Resveratrol on Treatment of Bleomycin-Induced Pulmonary Fibrosis in Rats

Recep Akgedik; Şükran Akgedik; Harun Karamanli; Sema Uysal; Bulent Bozkurt; Duygu Ozol; Ferah Armutcu; Zeki Yıldırım


Sleep and Breathing | 2014

Influence of CPAP treatment on airway and systemic inflammation in OSAS patients

Harun Karamanli; Duygu Ozol; K. Serife Ugur; Zeki Yıldırım; Ferah Armutcu; Bulent Bozkurt; Ramazan Yigitoglu


Sleep and Breathing | 2011

Influence of snoring on microalbuminuria in diabetic patients

Duygu Ozol; Ayse Carlioglu; Harun Karamanli; Recep Akgedik; Feridun Karakurt; Zeki Yıldırım

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Duygu Ozol

Turgut Özal University

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