Harusachi Kanazawa

Primary malignant fibrous histiocytoma of the mandible: review of literature and report of a case

Sao Paulo, Brazil, Roca, 2000 6. Rowe NL, Williams JL: Rowe and Williams’ Maxillofacial Injuries (ed 2). London, England, Churchill Livingstone, 1994, p 387-404 7. Teixeira ACB, Luz JGC, Araujo VC, et al: Healing of the displaced condylar process fracture: An experimental study. J Craniomaxillofac Surg 26:326, 1998 8. Iizuka T, Thoren H, Annino DJ Jr, et al: Midfacial fractures in pediatric patients. Arch Otolaryngol Head Neck Surg 121:1366, 1995 9. Enlow DH: Facial Growth (ed 3). Philadelphia, PA, Saunders, 1990 10. Precious DS, Delaire J, Hoffman CD: The effects of nasomaxillary injury on future facial growth. Oral Surg Oral Med Oral Pathol 66:525, 1988 11. Rock WP, Brain DJ: The influence of nasal trauma during childhood on growth of the facial skeleton. J Laryngol Otol 97:917, 1983 12. Wada T, Kremenak CR, Miyazaki T: Midfacial growth effects of surgical trauma to the area of the vomer in beagles. J Osaka Univ Dent Sch 20:241, 1980 13. Ousterhout DK, Vargervik K: Maxillary hypoplasia secondary to midfacial teruma in childhood. Plast Reconstr Surg 80:491, 1987 14. Shapiro PA, Kokich VG, Hohl T, et al: The effects of early Le Fort I osteotomies on craniofacial growth of juvenile Macaca nemestrina monkeys. Am J Orthod 79:492, 1981 15. Munro IR: The effect of total maxillary advancement on facial growth. Plast Reconstr Surg 62:751, 1978

Solitary plasmacytoma of the mandible. Case report and review of the literature.

A case of solitary plasmacytoma of the mandible is presented. Review of the literature disclosed the following characteristics regarding the clinical course and prognosis. The patients ages ranged from 34 to 76 years, with a mean of 53 years; there was a marked preponderance of males. The site of predilection was the posterior portion of the mandible. The common symptom was a non-painful swelling of the mandible of long duration, and radiological features were non-specific. Monoclonal immunoglobulin was initially detected in 42% of the evaluated patients. The majority of patients were treated with radiation therapy with a mean dose of 48Gy with or without surgery. The period of follow-up ranged from 4 months to 12 years, and 17% of the patients progressed to multiple myeloma within 1 year.

Presence of the Third Molar as a Risk Factor in Mandibular Angle Fractures

Abstract Objective: To assess the influence of the presence and position of the mandibular third molar on the incidence of mandibular angle fractures. Patients and Methods: This was a retrospective cohort study of 240 mandibular fractures in 151 patients from August 1993 to July 2002. The presence and degree of impaction of mandibular third molars were assessed for each patient and related to the occurrence of mandibular angle fractures. Results: Forty eight patients (43.2 %) had mandibular angle fracture among 111 patients with mandibular third molars and 5 patients (12.5%) had mandibular angle fracture among 40 patients without mandibular third molars. The incidence of mandibular angle fractures was significantly higher when the mandibular third molar was present (p = 0.0004). There was a statistically significant variation in the risk for the occurrence of mandibular angle fractures depending on state of eruption of the mandibular third molar (p = 0.005). Conclusion: This study provides evidence that patients with mandibular third molars are significantly more susceptible to mandibular angle fracture than those without mandibular third molars.

Effects of ACNU, a water-soluble nitrosourea derivative, on survival and cell kinetics of cultured HeLa S3 cells

Effects of a water-soluble nitrosourea, 1(4-aminomethylpyrimidine-5yl)methyl-3-(2-chloroethyl)-3-nit rosourea hydrochloride (ACNU) was investigated on cultured HeLa S3 cells with regard to their lethality and cell progression through the cell cycle. The survival curve of exponentially growing cells exposed to increasing concentrations of the drug for 1 hr was characterized by a threshold type of response (Do = 7.0 micrograms/ml X 1 hr, Dq 3.5 micrograms/ml X 1 hr). Throughout the cell cycle, ACNU exerted its main killing effect on cells in the G1 and G2 + M phases, whereas cells in S were resistant to the drug. The change in their age-response was due to the Do value of the dose-survival curve rather than the Dq. Effects of cell progression were also examined at a low concentration of ACNU (5.0 micrograms/ml), which allowed 80% of treated cells to survive. Delayed transit was observed in the S phase, and more markedly in the G2 + M phase. The magnitude of these perturbations depended on the position of the cell cycle at which the drug was administered. Cells treated in the G1 and early S phases showed a much longer duration of S and G2 + M phases than cells treated in mid-S phase. Cells treated in the late S and G2 phases could normally pass through mitosis, but were subsequently blocked in the G2 phase following a prolonged S phase in the next cell cycle. These studies revealed that there seems to be some positive relationship of the effect of ACNU on cell progression and cell killing throughout the cell cycle.

Mucosal defect repair with a polyglycolic acid sheet and fibrin glue after resection of large pleomorphic adenoma of the palate

Introduction: treatment of choice for pleomorphic adenoma of the hard palate is wide local resection of the tumor including the overlying mucosa and underlying periosteum. Most conventional methods for covering the resulting palatal wound are prosthetic devices. In this case, we examined the validity of grafting a polyglycolic acid sheet and fibrin glue over a mucosal defect of the palate with a bony surface, as a substitute for a surgical splint. case report: A 39-year-old male presented with a large, solid mass located on the right hard palate. Fine-needle aspiration cytology suggested pleomorphic adenoma. the patient underwent wide local resection of the lesion, and the mucosal defect was immediately covered with polyglycolic acid sheets, that were fixed with a fibrin glue spray. these sheets were tightly placed and remained in the wound, which led to complete epithelialization of the wound surface. conclusion: Grafting the polyglycolic acid sheet with fibrin glue fixation is a useful Harusachi Kanazawa1, Atsushi Kasamatsu2, Katsuhiro Uzawa3 Affiliations: 1DDS, PhD, Chief, Division of Dentistry and Oral-Maxillofacial Surgery, Sanmu Medical Center, 167 Naruto Sanmu City, Chiba 289-1326, Japan; 2DDS, PhD, Instructor, Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, 1-8-1 Inohana, Chuoku, Chiba City, Chiba 260-8670, Japan; 3DDS, PhD, Associate professor, Department of Dentistry and Oral-Maxillofacial Surgery, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan. Corresponding Author: Harusachi Kanazawa, 167 Naruto, Sanmu City, Chiba, Japan, 260-8677; Email: h-kanazawa@ sanmu-mc.jp Received: 25 November 2015 Accepted: 27 April 2016 Published: 18 May 2016 substitute for the conventional surgical splint to cover a mucosal defect of the hard palate.