Harvey L. Gordon

Nephrogenic adenoma of bladder in immunosuppressed renal transplantation

A case of nephrogenic adenoma is reported in an immunosuppressed renal transplant recipient. The nature of the lesion is discussed, and a possible relationship between benign tumors and impaired immunologic surveillance is considered.

Lactate and Malate Dehydrogenase and α-Esterases in Oligospermia

Lactate dehydrogenase (LDH), malate dehydrogenase, and α-esterase were studied electrophoretically in a total of 99 semen samples obtained from normal, vasectomized, oligospermic, and infertile males. The enzymatic patterns were compared with total sperm count and percentage sperm motility. Lactate dehydrogenase X was absent in semen samples from oligospermic as well as vasectomized males. An extra LDH band (between the second and third LDH bands) was detectable in samples which had a low sperm count but higher motility (80 to 90%). This extra band was absent in samples with higher sperm count regardless of the level of percentage motility, suggesting that the extra band possibly may be related to motility factors of low sperm count but not normal sperm count. The fastest moving α-esterase bands were absent in samples from oligospermic or vasectomized males. These bands were also absent in samples from infertile patients having a very low sperm count. It is not clear whether the fast-moving esterase bands are related to sperm count or possible differences in hormonal levels of individuals with low or zero sperm count samples. The patterns of malate dehydrogenase did not differ in individuals with zero, low, or normal sperm count.

Innovation in Human Research Protection: The AbioCor Artificial Heart Trial

E. Haavi Morreim, University of Tennessee College of Medicine George E. Webb, Hospice Institute, Alliance of Community Hospices, Louisville, KY Harvey L. Gordon, Baylor College of Medicine Baruch Brody, Baylor College of Medicine David Casarett, University of Pennsylvania Health System Ken Rosenfeld, University of California, Los Angeles James Sabin, Harvard University John D. Lantos, University of Chicago Barry Morenz, University of Arizona Robert Krouse, University of Arizona Health Sciences Center Stan Goodman, University of California, Los Angeles

Serum Immunoglobulin Levels in Vasectomized Men: Preliminary Report

Seventy-five men undergoing vasectomy were tested by radial immunodiffusion assay prevasectomy and at 6 weeks and 3, 6, and 12 months postvasectomy for possible changes in serum immunoglobulin (Ig) levels. No significant changes occurred when the results were analyzed on a group basis per time period. However, when each individuals prevasectomy Ig level was considered as his norm, significant changes appeared to occur in serum IgG levels at 6 weeks, 6 months, and 12 months postvasectomy; in serum IgM levels at 6 weeks; but not, to date, in serum IgA levels. Seasonal, environmental, and infectious factors do not seem to be associated with the changes found. No significant seminal Ig changes have been demonstrated. Consideration of these findings and implications for possible immunopathology are briefly discussed.