Hasan Deniz Demir

Evaluation of conventional imaging techniques on preoperative localization in primary hyperparathyroidism

We aimed to evaluate the diagnostic and preoperative localization capacity of 99mTc methoxyisobutylnitrile (MIBI) parathyroid scintigraphy and ultrasonography (USG) in enlarged parathyroid glands in the primary hyperparathyroidism (pHPT) as well as the relationship between the success rate of these techniques and biochemical values. In this study, we retrospectively evaluated 39 patients with clinical and biological evidence of pHPT who referred to the university hospital for MIBI parathyroid scintigraphy. Patients were examined with USG and double-phase MIBI parathyroid scintigraphy for the detection of enlarged parathyroid glands. Preoperative serum intact parathyroid hormone (iPTH) levels, calcium (Ca), phosphate and alkaline phosphatase measurements were obtained. A total of 45 parathyroid lesions in 39 patients were reviewed. Thirty-four patients had a single adenoma and 5 patients with multi-gland disease had 11 abnormal parathyroid glands including three adenomas, whereas the remaining 8 glands showed hyperplasia. The overall sensitivities of MIBI parathyroid scintigraphy, USG and combined techniques were 85.3%, 72.5% and 90.4%, respectively; the positive predictive values (PPV) were 89.7%, 85.2% and 92.6%, respectively. The most successful approach for detection of enlarged parathyroid glands in hyperparathyroidism is the concurrent application of USG and MIBI parathyroid scintigraphy modalities. The concomitancy of thyroid diseases decreases the sensitivity of both MIBI parathyroid scintigraphy and USG in enlarged parathyroid glands.

The relationship between thyroglobulin (Tg) levels and distant metastases before radioiodine (RAI) treatment in differentiated thyroid carcinomas

The aim of our study is to determine the relationship between distant metastases and thyroglobulin (Tg) levels measured before radioiodine (RAI) treatment in differentiated thyroid carcinomas. Sixty seven patients with near total or total thyroidectomy were included in the study. Fifty patients did not have lymph node or distant metastases (Group 1), and 17 patients had distant metastases (Group 2). Tg and anti-Tg levels of these patients were measured before RAI treatment when TSH>30 mU/l. Serum Tg levels were found 8,5±10,6 ng/ml and 307±142 ng/ml in Group 1 and Group 2, respectively. There was a significant difference between the mean Tg levels of Group 1 and 2 (p

Is it necessary to perform control diagnostic 131I whole body scan after remmant ablation in differentiated thyroid carcinoma patients who have stimulated Tg levels under 2 ng/ml?

Abstract Background: The aim of this retrospective study is to evaluate whether diagnostic I-131 whole body scan (DWBS) performed 6-12 months after thyroid remnant ablation is necessary or not in differentiated thyroid

Stimulated Tg level measurements may be avoided in differentiated thyroid carcinoma patients who have undetectable basal Tg levels

Abstract Background: The aim of this retrospective study is to evaluate the diagnostic value of undetectable basal thyroglobulin (Tg) levels measured 6 months after ablative 131I treatment (AIT) in patients

Kliniğimizde radyoaktif iyot tedavisi alan diferansiye tiroid karsinomlu hastaların demografik analizi

Our aim was to determine the correlation of a well differentiated thyroid carcinoma with gender and age. Our retrospective study evaluated 736 patients received ablation therapy between 2008 and 2011, consisted of 600 females and 136 males. The rate of female to male was 4,4/1 in differentiated thyroid carcinoma. Our patients aged between 14 to 89 during the diagnosis with a mean age of 46,9±12,8. The mean diagnosis age was 47,2±13,1 for females, while 46,1±13,3 for males. Papillary carcinoma was found as the most common type of tumor with 87% and the second common type was follicular carcinoma with 11%. In all type of thyroid cancers female patients were more than males. There was not any statistically significant difference between the mean diagnosis age for follicular thyroid cancer and for papillary thyroid cancer.