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Dive into the research topics where Hatice Ugurlu is active.

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Featured researches published by Hatice Ugurlu.


Spine | 2004

Gabapentin Is a First Line Drug for the Treatment of Neuropathic Pain in Spinal Cord Injury

Funda Levendoglu; Cemile Oztin Ogun; Onder Murat Ozerbil; Tunç Cevat Öğün; Hatice Ugurlu

Study Design. Prospective, randomized, double blind, placebo-controlled, crossover clinical trial. Objectives. To determine the efficacy of gabapentin in the treatment of neuropathic pain related to spinal cord injury. Summary of Background Data. Neuropathic pain is initiated or caused by a primary lesion or dysfunction in the nervous system. Neuropathic pain associated with spinal cord injury is quite refractory, and current treatments are not effective. Gabapentin, an anticonvulsant, has become the first choice in the treatment of neuropathic pain. The place of gabapentin in the treatment of spinal cord injury-related neuropathic pain was questioned in only a few recent reports; however, they are retrospectively designed, nonstandardized, and uncontrolled studies, or involve a very small series of patients using less than optimum doses. Methods. A total of 18-week study period included a 4-week medication/placebo titration period. This was followed by a 4-week stable dosing period when the patients continued to receive maximum tolerated doses, a 2-week washout period, then a crossover of 4 weeks of medication/placebo titration, and another 4 weeks of stable dosing period. Twenty paraplegic patients (female/male: 7/13) with complete spinal cord injury at the thoracic and lumbar level, aged between 20 and 65 years, with neuropathic pain for more than 6 months were recruited for the study. Results. All patients completed the study. Gabapentin reduced the intensity as well as the frequency of pain, relieved all neuropathic pain descriptors except the itchy, sensitive, dull, and cold types, and improved the quality of life (P < 0.05). Conclusions. Gabapentin can be added to the list of first-line medications for the treatment of chronic neuropathic pain in spinal cord injury patients. It is a promising new agent and offers advantages over currently available treatments.


Hemodialysis International | 2006

Physical disability, psychological status, and health-related quality of life in older hemodialysis patients and age-matched controls

Lutfullah Altintepe; Funda Levendoglu; Nilsel Okudan; Ibrahim Guney; Ali Savaş Çilli; Hatice Ugurlu; Zeki Tonbul; Hakkı Gökbel; Suleyman Turk

We aimed at comparing the elderly adults and normal subjects with regard to their disability, psychological status, and quality of life (QOL). One hundred and twenty‐five dialysis patients and 61 controls were recruited in the study. Depression and anxiety symptoms of the patients were evaluated with the Psychological Symptom Screening List (SCL 90‐R). For evaluating the disability, the Rivermead mobility index (RMI) was utilized. For evaluating the QOL, we used the short form‐36 (SF‐36) scale. The Rivermead mobility index of the patients (9.6±3.4) was found. When compared with controls, dialysis patients had higher levels of disability (p=0.0001). Depression and anxiety symptom scores of these patients were also significantly higher than that of the controls (p<0.05). There was a correlation between the disability and depression symptom scores (r: 0.171, p=0.037). Both physical and mental capacity scores of the dialysis patients were lower than those of the controls (p<0.05 and p<0.05) QOL scores for elderly hemodialysis patients were found to be lower. Their disability was higher, making them dependable on others during their daily lives. Specific exercise programs should be developed for these patients. Even the smallest effort in this regard will result in improvements in physical functioning while bringing them significant benefits.


Rheumatology International | 2004

Ventricular function abnormalities in active rheumatoid arthritis: a Doppler echocardiographic study.

Funda Levendoglu; Ahmet Temizhan; Hatice Ugurlu; Ayse Özdemir; Mehmet Yazici

ObjectiveThe aim of the present study was to evaluate cardiac involvement in patients with active rheumatoid arthritis (RA).MethodsForty patients with active RA participated. All were submitted to standard Doppler echocardiography and myocardial performance index (MPI) grading.ResultsThere were left and right ventricular diastolic function abnormalities in RA patients. Left ventricular MPI was also significantly higher than in controls (P<0.05). A relationship was found between left ventricular early diastolic (E)/atrial (A) flow velocities (E/A ratio), isovolumic relaxation time (IRT), and disease duration (r=−0.47 and P=0.002, r=0.618 and P=0.000, respectively).ConclusionDiastolic function was impaired in both ventricles in patients with active RA. There was a direct relationship between some of the parameters of left ventricular diastolic function and disease duration as well. These findings suggest a subclinical myocardial involvement in RA patients.


General Hospital Psychiatry | 2010

Axis I and Axis II psychiatric disorders in patients with fibromyalgia

Faruk Uguz; Erdinc Cicek; Ali Salli; Ali Yavuz Karahan; Ilknur Albayrak; Nazmiye Kaya; Hatice Ugurlu

OBJECTIVE To determine the current prevalence of Axis I and Axis II psychiatric disorders in patients with fibromyalgia. METHOD The study sample includes 103 patients with fibromyalgia and 83 control subjects. Axis I and Axis II disorders were determined by structured clinical interviews. RESULTS The rate of any Axis I psychiatric disorder (47.6% vs. 15.7%), major depression (14.6% vs. 4.8%), specific phobia (13.6% vs. 4.8%), any Axis II disorder (31.1% vs. 13.3%), obsessive-compulsive (23.3% vs. 3.6%) and avoidant (10.7% vs. 2.4%) personality disorders were significantly more common in the patient group compared to the control group. CONCLUSION Our results suggest that a considerable proportion of patients with fibromyalgia also present with Axis I and Axis II psychopathologies.


Journal of Rehabilitation Medicine | 2011

Effectiveness of back school for treatment of pain and functional disability in patients with chronic low back pain: a randomized controlled trial.

Nilay Sahin; Ilknur Albayrak; Bekir Durmus; Hatice Ugurlu

OBJECTIVE To evaluate the effectiveness of the addition of back school to exercise and physical treatment modalities in relieving pain and improving the functional status of patients with chronic low back pain. DESIGN A randomized controlled trial. PATIENTS A total of 146 patients with chronic low back pain were enrolled in the study. METHODS Subjects were divided into 2 groups: the back school group received exercise, physical treatment modalities and a back school programme; and the control group received exercise and physical treatment modalities. Treatment efficacy was evaluated at the end of treatment and 3 months post-treatment, in terms of pain, measured with the Visual Analogue Scale, and functional status, measured with the Oswestry Low Back Pain Disability Questionnaire. RESULTS In both groups, Visual Analogue Scale and Oswestry Low Back Pain Disability Questionnaire were significantly reduced after therapy (p < 0.01), but the difference between the scores at the end of treatment and 3 months post-treatment was not significant. There was a significant improvement in Visual Analogue Scale and Oswestry Low Back Pain Disability Questionnaire in the back school group compared with the control group at the end of therapy and 3 months post-treatment (p < 0.05). CONCLUSION The addition of back school was more effective than exercise and physical treatment modalities alone in the treatment of patients with chronic low back pain.


Rheumatology International | 2008

Isokinetic evaluation of knee extensor/flexor muscle strength in patients with hypermobility syndrome.

Nilay Sahin; Hatice Ugurlu; Ender Berker

Benign joint hypermobility syndrome (BJHS) is a syndrome with musculoskeletal pain originating from the increased laxity of the joints and the ligaments. The study was to compare the isokinetic strength of knee extensor/flexor muscles of BJHS patients with healthy controls. Forty patients diagnosed as having BJHS with Brighton criteria and 45 years of age, height and weight-matched healthy controls were recruited for the study. Isokinetic testing was performed with isokinetic dynamometry of Biodex System 3Pro and measurements were recorded at knee extension/flexion pattern concentrically at 60, 180, and 240°/s angular velocities. The study group was also evaluated for functional impairment and pain by HAQ and VAS respectively. Knee extensor muscle strength was significantly lower in the patient group compared with the controls. It was hypothesized that the muscle weakness in the study group was related to lengthening of the quadriceps muscle and pain-related inactivity as well as joint instability and proprioception defect.


Disability and Rehabilitation | 2012

The efficacy of electrical stimulation in reducing the post-stroke spasticity: a randomized controlled study

Nilay Sahin; Hatice Ugurlu; Ilknur Albayrak

Purpose: The purpose of this study is to evaluate the efficacy of surface electrical stimulation on the spasticity occurring in the wrist flexor muscles after a cerebrovascular event. Method: Hemiplegic patients with stage 2–3 spasticity in the wrist muscles based on the Ashworth scale were divided into two groups. Both groups were applied stretching. One group was additionally administered neuromuscular electrical stimulation (NMES) to the wrist extensors, in the form of pulsed current, 100 Hz, with a pulse duration of 0.1 msec, and a resting duration of 9 seconds, for 15 minutes to provide the maximum muscular contraction. The efficacy of the treatment was evaluated using the following: modified Ashworth scale (MAS), Fmax/Mmax ratio, Hmax/Mmax ratio, wrist extension range of motion (ROM). The daily activities were assessed by Functional Independence Measurement (FIM) and the motor recovery was evaluated by Brunnstrom motor staging. Results: Both groups revealed a significant recovery after the treatment based on the MAS, the electrophysiological evaluation results, wrist ROM, FIM and Brunnstrom motor staging. The group receiving the combined treatment showed a better recovery in terms of MAS, wrist ROM, FIM and Brunnstrom motor staging compared to the group doing the stretching alone. Conclusions: The results of this study showed that NMES given together with stretching of the wrist extensor muscles was more effective than stretching of the wrist extensor muscles alone in reducing spasticity. Implications for Rehabilitation There is a wide range of treatment options for spasticity, from conservative treatments (medications, splint, physical treatment modalities, and exercise) to surgery. The efficacy of electrical stimulation in spasticity is still controversial. Electrical stimulation treatment applied together with wrist extensor muscles passive stretching exercise is effective in reducing spasticity.


The Journal of Sexual Medicine | 2012

Evaluation of Sexual Dysfunction in Women with Rheumatoid Arthritis: A Controlled Study

Halim Yilmaz; Halime Almula Demir Polat; Sema Yilmaz; Gulten Erkin; Sami Küçükşen; Ali Salli; Hatice Ugurlu

OBJECTIVE To evaluate sexual function in women with rheumatoid arthritis (RA) and compare them with healthy controls. MATERIALS AND METHODS Ninety-five patients with RA and 108 healthy controls were included in the study. Depression levels and sexual functions of all participants were evaluated by the Beck Depression Inventory (BDI) and Index of Female Sexual Function (IFSF), respectively. Morning stiffness in women with RA, pain (Visual Analog Scale--VAS), disability rate (Health Assessment Questionnaire--HAQ), and disease activity score (DAS-28) were defined. RESULTS Total IFSF and mean of IFSF subgroup scores and significance of sexual life score were lower in patients with RA than controls, whereas mean BDI score was higher. The mean of the total IFSF scores was significantly lower in patients with RA with BDI≥17 than that of patients with BDI<17. The mean of the total IFSF score decreased as disease severity increased. There was a strong negative correlation between total IFSF and DAS-28 scores, a moderate negative correlation between total IFSF score and HAQ, BDI, VAS score, age, and morning stiffness, and weak negative correlation between total IFSF and body mass index. CONCLUSION RA is observed to have negative effects on sexual functions of women. Presence of depressive symptoms with RA and increased disease severity increase the degree of sexual dysfunction. Women patients with RA should also be asked about their sexual lives while being evaluated.


Isokinetics and Exercise Science | 2010

The effect of two exercise programs on various functional outcome measures in patients with osteoarthritis of the knee: A randomized controlled clinical trial

Ali Salli; Nilay Sahin; Hatice Ugurlu

We aimed to investigate the effects of isometric and combined concentric-eccentric (C-E) isokinetic types of exercise applied to the knee muscles in patients with knee osteoarthritis (OA) in an attempt to identify which type of exercise would be most effective in terms of pain relief, functional status, quality of life, and muscular strength. This was a controlled trial in which 71 patients were randomized into three groups. The first group was assigned to C-E, the second group to isometric isokinetic exercises, while the third, control group, was only given paracetamol. A visual analog scale for pain, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Short From-36 (SF-36) for functional status and quality of life, and the isokinetic test for muscular strength were evaluated. Significant improvements were recorded in all groups for pre and post-treatment pain, the WOMAC and the SF-36 (P < 0.001). Among the exercise groups, improvement was significantly better in the C-E, isokinetic exercise group as compared with the isometric exercise group (P < 0.001). Isokinetic exercises are recommended as a treatment modality. However, the long-term effects of these exercises on pain and osteoarthritis progression need to be investigated.


Journal of Spinal Cord Medicine | 2008

A Placebo-Controlled, Multicenter, Randomized, Double-Blind, Flexible-Dose, Two-Way Crossover Study to Evaluate the Efficacy and Safety of Sildenafil in Men With Traumatic Spinal Cord Injury and Erectile Dysfunction

Süreyya Ergin; Berrin Gunduz; Hatice Ugurlu; Koncuy Sivrioglu; Serna Oncel; Haydar Gök; Belgin Erhan; Funda Levendoglu; Ozlem Senocak

Abstract Background/objective: To show the efficacy, safety, and tolerability of sildenafil in men with erectile dysfunction (ED) associated with complete or incomplete spinal cord injury (SCI) and to assess its effects onquality of life (Qol) using the Life-Satisfaction Check List. Methods: This was a placebo-controlled, multicenter, randomized, double-blind, flexible-dose, 2-way crossover study with a 2-week washout period between each phase. Patients with ED attributable to SCI(Sexual Health Inventory-Male score ≤21) received 50 to 100 mg sildenafil (n = 24) or placebo (n = 26). Results: Compared with placebo, sildenafil produced higher levels of successful sexual stimulation,intercourse success, satisfaction with sexual life and sexual relationship, erectile function, overall sexual satisfaction, and an improved Erectile Dysfunction Inventory of Treatment Satisfaction score, with no clinically relevant effects onvital signs. Sildenafil seemed more effective in patients with incomplete SCI than in those with complete SCI, producing significant improvements, compared with placebo, in a number of measures only in patients with incomplete SCI. All patients who expressed a preference selected sildenafil over placebo, although the drug had no effect on patient Qol. Sildenafil was well tolerated, with a profile comparable to that of placebo. Conclusions: Compared with placebo, treatment with oral sildenafil safelyand effectively improved erectile function in patients with ED attributable to SCI, especially in those with incomplete injury, and was theagent of choice in those who expressed a preference.

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Sami Küçükşen

American Physical Therapy Association

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Sinan Bağçacı

American Physical Therapy Association

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