Hatice Uslu

Effects of septoplasty and septal deviation on nasal mucociliary clearance

To evaluate the effect of septal pathology and surgery on nasal mucociliary clearance. A radioisotope method was used to measure the velocity of nasal mucociliary transport. Nasal mucociliary clearance was measured before and after septal surgery using technetium−99 m macroaggregated albumin. Fifteen patients (mean age: 20 ± 8 years; 11 males, four females) were studied pre‐operatively, but scintigraphy could be repeated only in 10 patients, 2 months after surgery. A group of 10 healthy volunteers were also studied. The clearance values obtained from the pre‐operative period (26.25 ± 9.45 min) were significantly higher than those of the post‐operative period (15.05 ± 6.35 min). The values obtained of control group (13.30 ± 3.15 min) were not significantly different from the post‐operative values of the patient group. Septal deviation affects the mucociliary activity. It is improved by surgery. This study showed that nasal septal deviation reduced the nasal mucociliary activity, and this can easily evaluated with scintigraphy.

Evaluation of active and passive transport mechanisms in genital tracts of IUD-bearing women with radionuclide hysterosalpingoscintigraphy

The objective of this study was to evaluate the active and passive transport mechanisms in the genital tracts of copper T-200 intrauterine device (IUD)-bearing women. (Tc-99m)HMPAO-labeled spermatozoa and (Tc-99m)-labeled albumin macrospheres were placed into the vagina at midcycle. Serial scintigraphic images were obtained over a period of 2 h. Migration of spermatozoa and particles in the genital tract and the direction of transport related to dominant follicle were evaluated. While active sperm migration was greatly inhibited, the passive transport of the particles was not affected in IUD-bearing women. The direction of radiolabeled particles and spermatozoa was toward the dominant follicle side. Passive transport was not affected, whereas active transport of spermatozoa was strongly inhibited in the genital tract by the presence of the IUD. However, the direction of active and passive transport related to dominant follicle side was unchanged in IUD-bearing women and was preferentially toward the tube ipsilateral to the dominant follicle.

Bone mineral density in malnourished children without rachitic manifestations

Background: The purpose of this study was to determine bone mineral density (BMD) of lumbar spine in malnourished children without rachitic manifestations, before and after dietary treatment and vitamin D supplementation, and to compare with healthy children of the same community.

Detection of orchitis and sacroiliitis due to brucellosis by 99mTc polyclonal human immunoglobulin scintigraphy.

Here, we report 1 case of Brucella orchitis detected by 99mTc human immunoglobulin scintigraphy and confirmed by testicular ultrasound. A 29-year-old farmer was admitted to our hospital with fever, fatigue, arthralgia, and painful scrotal swelling that had appeared 12 days before admission. Clinically, right sacroiliitis was recorded through the Fabere test Unilateral sacroiliitis and orchitis were detected by 99mTc human immunoglobulin scintigraphy. Hypoechoic left testicular lesions and swelling of the concurrent epididymis were seen on a testicular ultrasound examination. Wright agglutination test and blood specimen culture for Brucella species were positive.

99mTc-labelled red blood cell single-photon emission computed tomography for the diagnosis and follow-up of juvenile nasopharyngeal angiofibroma.

AimTo confirm the usefulness of blood pool scintigraphy with 99mTc-labelled red blood cells (99mTc-RBCs) in the diagnosis and follow-up of juvenile nasopharyngeal angiofibroma. MethodsA prospective study design was used. 99mTc-RBCs were prepared by a modified in-vivo method. After the rapid intravenous injection of 370–740 MBq of 99mTc-RBCs, dynamic imaging of 1-min duration was performed. After dynamic imaging, static acquisitions at 5 min (second phase: blood pool phase) and 2 h (third phase: static image) were obtained. In addition, single-photon emission computed tomography (SPECT) imaging was performed at 2 h. SPECT images were obtained using a rotating gamma camera (GE-Starcam 4000 XR/T). ResultsAll patients showed no activity in the first phase and mild activity in the second phase (blood pool phase). All patients with juvenile nasopharyngeal angiofibroma showed a prominent increased activity in the third phase and in SPECT images. ConclusionsThis study shows that blood pool scintigraphy with 99mTc-RBC SPECT is very accurate, easy to perform and a suitable alternative to pre-operative and post-operative imaging techniques, including computed tomography scan, magnetic resonance imaging (MRI) and MRI angiography, for the detection of juvenile nasopharyngeal angiofibroma.

Comparison of 99mtc-MIBI and 201Tl/99mtc Subtraction Scintigraphy in Patients with Hyperparathyroidism

Backgrounds: 201Tl/99mTc-pertechnetate subtraction scintigraphy is recognized as a useful procedure in the preoperative localization of parathyroid adenomas. 99mTc-MIBI has recently been introduced for parathyroid imaging. The aim of this study was to compare diagnostic accuracy of parathyroid scan performed with 99mTc-MIBI and 201Tl/99mTc-pertechnetate subtraction in patients with hyperparathiroidism. Methods: Twenty-one patients (17 femals and 4 males, mean age: 50 years) with a clinical and laboratory diagnosis of hyperparathyroidism were included in the study. 201Tl/99mTc-pertechnetate subtraction and earlydelayed cervico-thoracic images of 99mTc-MIBI scans were performed in all patients. The results of parathyroid images obtained with 99mTc-MIBI were compared with those obtained with 201Tl/99mTc-pertechnetate subtraction scintigraphy, ultrasonography and histopathological findings after surgical exploration of the neck. Results: Positive scans in the seven and negative scans in the twelve patients were showed in both imaging methods. In one case, 99mTc-MIBI scan was negative but 201Tl/99mTc-pertechnetate subtraction scan was positive. In another case, while 99mTc-MIBI scan was positive 201Tl/99mTc-pertechnetate subtraction scan was negative. Surgical exploration of the neck was performed in patients (n = 9) with positive 99mTc-MIBI and 201Tl/99mTcpertechnetate subtraction scans. Parathyroid adenoma in 7 and hyperplasia in 2 patients were detected. Ultrasonography was also negative in 12 patients whose both scans were negative. There was one falsenegative in 99mTc-MIBI scan and one false-negative in 201Tl/99mTc-pertechnetate subtraction scan. The sensitivity and the specificity of both scans were 88% and 100%, respectively. Conclusions: Both 99mTc-MIBI and 201Tl/99mTc-pertechnetate subtraction scans had the same sensitivity rate for the detection of pathological parathyroid tissue. Scintigraphy is simple, safe and first step imaging technique for the detection of hyperfunctioning parathyroid glands.

Compensatory hypertrophy of the left liver lobe: confused with abdominal infection on Tc-99m HMPAO leukocyte imaging.

Radionuclide-labeled leukocyte imaging is a useful method for assessing various aspects of inflammatory bowel disease. The accuracy of Tc-99m HMPAO-labeled leukocyte imaging has exceeded that of conventional radiologic and endoscopic techniques. The spleen, liver, bone marrow, kidneys, bowel, bladder, and major blood vessels are normally visualized on tagged leukocyte scintigraphy. The time to image Tc-99m HMPAO-labeled leukocytes depends, in part, on the type and location of possible infection. Four-hour imaging helps to differentiate physiologic early hepatic uptake from abnormally increased uptake seen with sepsis. Focal collections of inflamed peritoneal fluid or sites of focal bowel inflammation can be mistaken for abscess. The authors report excessive compensatory hypertrophy of the left lobe of the liver on ultrasonography, computed tomography, and labeled leukocyte scintigraphy. Scintigraphic findings could be confused with abdominal infection with possible inflammatory bowel disease.