Heidi May

GLYCA AND GLYCB, NOVEL NMR BIOMARKERS OF INFLAMMATION, STRONGLY PREDICT FUTURE CARDIOVASCULAR EVENTS, BUT NOT THE PRESENCE OF CORONARY ARTERY DISEASE (CAD), AMONG PATIENTS UNDERGOING CORONARY ANGIOGRAPHY: THE INTERMOUNTAIN HEART COLLABORATIVE STUDY

GlycA and GlycB are novel nuclear magnetic resonance spectroscopy (NMR) signals in plasma arising from the glycosylation of circulating acute phase proteins, especially fibrinogen, a1-antichymotrypsin, haptoglobin-1, a1-antitrypsin, complement C3 and a1-acid glycoprotein. These acute phase proteins

INCIDENCE OF DEMENTIA IN RELATION TO GENETIC VARIANTS AT 4Q25 AND APOE ɛ4 IN ATRIAL FIBRILLATION PATIENTS

Genetic predisposition to dementia has been strongly sought, but risk loci remain elusive. Atrial fibrillation (AF), a known risk factor for cerebrovascular accidents (CVA), was recently linked with dementia, especially in a younger population. Two chromosomal loci, 4q25 and 16q22, are associated

BOTH THE NOVEL NMR BIOMARKER OF INFLAMMATION, GLYCA, AND HS-CRP ARE INDEPENDENT AND ADDITIVE PREDICTORS OF FUTURE CARDIOVASCULAR EVENTS AMONG PATIENTS UNDERGOING CORONARY ANGIOGRAPHY: RESULTS FROM THE INTERMOUNTAIN HEART COLLABORATIVE STUDY

Background: GlycA, a novel marker of inflammation, has been associated with future CV risk among patients with or without pre-existing coronary artery disease (CAD). Whether GlycA is an independent and additive predictor of high sensitivity C-reactive protein (HS-CRP) needs further study. Methods:

DIFFERENTIAL ASSOCIATION OF HIGH-DENSITY LIPOPROTEIN PARTICLE SUBCLASSES AND GLYCA, A NOVEL INFLAMMATORY MARKER, IN PREDICTING CARDIAC DEATH AMONG PATIENTS UNDERGOING ANGIOGRAPHY: THE INTERMOUNTAIN HEART COLLABORATIVE STUDY

HDL particle (HDL-P) concentrations are comprised of particles that vary in size and composition, and potentially, in risk prediction. Inflammation is known to modulate HDL function. Whether increased inflammation alters associations of HDL subclasses with CAD needs further study. Pts (N=2,848) of

IMRS-HF: A CLINICAL DECISION TOOL FOR PREDICTING 30-DAY HOSPITAL READMISSION AMONG HEART FAILURE PATIENTS

Innovative strategies and tools for stratification of 30-day readmission (30dR) risk are needed due to penalties legislated in the Affordable Care Act (ACA). The Intermountain Risk Score (IMRS) is a sex-specific tool derived to predict mortality using the complete blood count (CBC), basic metabolic

IMPROVEMENT OF CHA2DS2-VASC RISK STRATIFICATION OF STROKE AND MORTALITY USING THE INTERMOUNTAIN RISK SCORE AMONG ATRIAL FIBRILLATION PATIENTS UNDERGOING CARDIAC CATHETERIZATION

Background: Oral anticoagulation therapy (OAC) guidelines recommend using CHA2DS2-VASc to determine OAC need in atrial fibrillation (AF). A usable tool, CHA2DS2-VASc is challenged by its predictive ability. Based on complete blood count and basic metabolic profile, the Intermountain Mortality Risk

WAIST CIRCUMFERENCE IS A STRONG PREDICTOR OF REGIONAL LEFT VENTRICULAR DYSFUNCTION IN ASYMPTOMATIC DIABETIC PATIENTS: THE FACTOR- 64 STUDY

Obesity is major health problem. Abdominal obesity is associated with the metabolic syndrome, coronary artery disease (CAD) and heart failure (HF). It is unclear if abdominal obesity is associated with left ventricular (LV) dysfunction independently of hypertension (HTN), CAD and weight among

CLINICAL EFFECTS OF TESTOSTERONE SUPPLEMENTATION AMONG HYPO-ANDROGENIC MEN WITH PREEXISTING SEVERE CORONARY ARTERY DISEASE: THE INTERMOUNTAIN HEART COLLABORATIVE STUDY

Low serum testosterone (T) is an independent risk factor for CV and total mortality. The impact of T therapy on CV outcomes, especially among older men with pre-existing severe CAD, is unknown. All men >50 yrs of age, with severe CAD (≥70% stenosis), a low (<212 ng/dL) baseline T level, 1 follow-

DISTRIBUTION AND PROGNOSTIC VALUE OF CORONARY ARTERY CALCIFICATION IN A HIGH RISK DIABETIC POPULATION: A SUB-ANALYSIS OF THE FACTOR64 STUDY

Coronary artery calcification (CAC) is pathognomonic for atherosclerosis and has been demonstrated to be associated with elevated risk of cardiovascular (CV) events. Diabetes (DM) is considered a “coronary equivalent” suggesting a risk of a first CV event comparable to that in those who have had

NEITHER SERUM VITAMIN D NOR CALCIUM LEVELS ARE ASSOCIATED WITH FLUORSOCOPIC SEVERITY OF CORONARY ARTERY CALCIFICATION AMONG PATIENTS UNDERGOING DIAGNOSTIC CORONARY ANGIOGRAPHY

Vitamin (Vit) D is a critical factor related to calcium (CA) absorption and metabolism, and Vit D levels are associated with serum CA levels, coronary artery disease (CAD) and major adverse CV events. Additionally, severity of coronary calcification has been used as a surrogate marker for CAD