Heike Spaderna

The State-Trait Depression Scales: An International Comparison

Equivalent English and German versions of the State-Trait Depression Scales (STDS) were developed and presented to samples of American and German students who were comparable with regard to gender and age. Factorial structure and equivalence of the two versions were determined by confirmatory factor analyses (CFA). The CFAs included multiple group analyses which were employed to compare factor patterns, loadings, factor variances and covariances across the two samples. In addition, statistical and psychometric properties of the items and scales were determined and mean differences between nationalities and genders on these scales were tested. In order to obtain information about the external validity, relationships between the STDS and tests which already exist in English and German (several depression scales as well as the State-Trait Personality Inventory, the State-Trait Anger Expression Inventory, and the Mainz Coping Inventory) were analysed.

Psychosocial and behavioural factors in heart transplant candidates – an overview

Mortality among heart transplant (HTX) candidates remains high. This review of the literature shows that psychosocial characteristics like depression, social isolation and coping strategies contribute to morbidity and mortality in heart failure (HF) patients, and may also be relevant to the prognosis of HTX candidates. Based on the research to date, physical activity favourably affects subjective and objective parameters not only in HF patients, but also in HTX candidates. Depression is prevalent among HTX candidates, especially in ischaemic patients, and seems to be related to earlier transplantation. Findings on the effects of depression on pretransplant mortality are conflicting. Not much is known concerning social isolation, coping, nutrition, or weight loss in this patient group. Identification of modifiable psychosocial and behavioural variables related to clinical status in this patient group is clearly needed and will aid the development of behavioural interventions to supplement medical therapies.

Social isolation and depression predict 12-month outcomes in the “waiting for a new heart study”

BACKGROUND Identification of modifiable psychosocial characteristics related to survival of heart transplant (HTx) candidates is needed to prevent clinical deterioration and improve prognosis. METHODS A multi-site, prospective study was conducted with 318 HTx candidates (18% female, 82% male; 53 +/- 11 years of age) newly listed at 17 hospitals in Germany and Austria. Baseline demographic and psychosocial characteristics were assessed by questionnaires. Indicators of disease severity (Heart Failure Survival Score, creatinine, cardiac index) and 12-month outcomes (death, high-urgency HTx, elective HTx, de-listing due to deterioration or improvement) were provided by Eurotransplant. RESULTS By 12 months, 33 patients died, 83 received an urgent HTx, 30 underwent an elective HTx, and 9 were de-listed due to clinical deterioration and 17 due to improvement. All measures of disease severity predicted outcomes. Controlling for disease severity, the number of social contacts contributed significantly to outcomes, favoring those who improved. Comparing socially isolated patients (<4 social contacts/month) who also had depression scores in the clinical range (high psychosocial risk group; n = 37) to those with >10 social contacts/month without depression (low psychosocial risk group; n = 47) revealed significant differences in the distribution of outcome frequencies (chi-square = 11.2, df = 4, p < 0.04). The high psychosocial risk group was more likely to have died/deteriorated and less likely to have improved than the low psychosocial risk group. CONCLUSIONS Regardless of disease severity, socially isolated HTx candidates who are also depressed may be at increased risk for clinical deterioration and mortality, indicating a need for psychosocial intervention.

Bericht über die deutsche Adaptation der State-Trait Depression Scales (STDS)

Zusammenfassung. Die neu entwickelte deutsche Version der State-Trait Depression Scales (STDS) stellt ein Instrument dar, mit dessen Hilfe in erster Linie depressives Erleben bei gesunden Probandinnen und Probanden der Forschung zuganglich gemacht werden soll. Anhand der Daten von funf nicht-klinischen Stichproben wurden verschiedene Analysen durchgefuhrt, um die Gute der Skalen zu prufen. Die interne Struktur wurde mittels konfirmatorischer Faktorenanalysen untersucht. Daneben wurden die psychometrischen Eigenschaften der Items und Skalen bestimmt. Um die externe Validitat der Skalen zu prufen, wurden die Zusammenhange zwischen den STDS und anderen Depressionsinstrumenten sowie weiteren State- und Traitskalen analysiert. An einer weiteren Stichprobe durchgefuhrte Latent-State-Trait-Analysen belegten die den Skalen zugrunde liegende State-Trait-Konzeption. Daruber hinaus wurde in einem Experiment mit kontrollierter Induktion von Erfolg und Miserfolg die Sensitivitat der State-Skala sowie das Zusammenwirke...

Depression and disease severity as correlates of everyday physical activity in heart transplant candidates.

It is unclear to what extent patients awaiting heart transplantation (HTx) engage in physical activities. We examined the everyday physical activity and its associations with depressive symptoms and disease severity in 318 patients newly registered for HTx in the multi‐site study ‘Waiting for a New Heart’ (aged 53.5 ± 11.4 years, 18% female patients). Participants completed questionnaires assessing depressive symptomatology and physical activity (number of physical activities, caloric expenditure associated with each activity), and estimated the distance they were able to walk without a break. Medical parameters at the time of listing [e.g. peak oxygen consumption (peakVO2); the German Transplant Society Score (GTSS)] were provided by Eurotransplant. Almost 50% of patients engaged in activities of daily living (housework, walking), but <10% engaged in regular exercise. All physical activity measures correlated significantly with peakVO2 (Ps < 0.01). Elevated depression scores were present in 39% of patients. Controlling for confounding variables (e.g. peakVO2, diastolic blood pressure, GTSS, age), depressive symptomatology accounted for additional variance in all physical activity measures (Ps < 0.05). The association of depressive symptoms with reduced physical activity suggests two important perspectives: attempts to increase physical activity (especially in the area of daily living) might benefit from targeting depression, and increased physical activity might also help to reduce depressive symptoms.

Composite risk scores and depression as predictors of competing waiting‐list outcomes: the Waiting for a New Heart Study

We evaluated two composite risk scores, (Heart Failure Survival Score, HFSS; German Transplant Society Score, GTSS), and depression as predictors of mortality and competing waiting‐list outcomes [high‐urgency transplantation (HU‐HTx), elective transplantation, delisting because of clinical improvement] in 318 heart transplant (HTx) candidates (18% women; aged 53 ± 11 years) from 17 hospitals and newly registered with Eurotransplant. Demographic variables and depression (Hospital Anxiety and Depression Scale, HADS) were assessed using questionnaires. Variables to compute HFSS and GTSS, age, medications, and outcomes were provided by Eurotransplant. At 12 months, 33 patients died, 83 received urgent HTx, 30 elective HTx, and 17 were delisted because of improvement. Applying cause‐specific Cox regressions, only the HFSS was significantly associated with 1‐year mortality [HR = 0.64 (95% CI = 0.43–0.95), P = 0.029]. The GTSS was the strongest predictor of HU‐HTx [HR = 1.02 (95% CI = 1.01–1.02), P < 0.001]. Low depression scores contributed significantly to clinical improvement, even after adjusting for age and risk scores [HADS: HR = 0.12 (95% CI = 0.02–0.89), P = 0.039]. These findings confirm the usefulness of composite risk scores for the prediction of mortality and HU‐HTx, validating both scores for their intended use. The finding that depression was an independent predictor of the waiting‐list outcome clinical improvement suggests that considering patients’ psychological attributes in addition to their medical characteristics is advisable.

Patients' sex and emotional support as predictors of death and clinical deterioration in the Waiting for a New Heart Study: results from the 1-year follow-up

Context Little is known about the role of patients sex and emotional support in the prognosis of heart transplant candidates. Objective To examine patients sex and emotional support as predictors of outcomes in the Waiting for a New Heart Study. Design, Setting, and Participants The Waiting for a New Heart Study is a prospective observational study of 318 patients (18% female) newly added to the waiting list for a heart transplant. Demographic, medical, psychosocial characteristics (including social support [ENRICHD Social Support Index; high vs low support]) were assessed at the time of wait-listing. Main Outcomes Time until death/delisting due to deteriorated health, considering competing outcomes (eg, transplantation) during the first 12 months after wait-listing were analyzed via cause-specific Cox proportional hazard models. Results—By 12 months, 32 men (12%) and 10 women (17%) had died/deteriorated. Medical risk was comparable across sexes. More men than women reported low emotional support (20.4% vs 8.6%) and being a past or current smoker (80.4% vs 56.9%). More women than men had low vocational level (93.1% vs 69.6%; all P values < .05). With medical risk and other confounding variables controlled for, female sex significantly increased risk of death/deterioration (hazard ratio, 2.30; 95% confidence interval, 1.04–5.12; P = .04); low emotional support further tended to increase the risk for this outcome (P = .07). As none of the 5 women with low emotional support had reached this end point, analyses were performed in the male sample and revealed that men with low emotional support were more than twice as likely to die/deteriorate than were men with high support (hazard ratio, 2.23; 95% confidence interval, 1.04–4.82; P = .04). Conclusion Women had worse survival while awaiting a heart transplant than men had, independent of confounding variables. Even though emotional support may be an important buffer for men, protective factors for women warrant further investigation with larger samples and/or longer follow-ups.

Dietary Habits are Related to Outcomes in Patients With Advanced Heart Failure Awaiting Heart Transplantation

BACKGROUND Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. METHODS AND RESULTS A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92). CONCLUSIONS These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.

Physical activity and depression predict event-free survival in heart transplant candidates.

OBJECTIVE This study prospectively evaluated the relationship of physical activity (PA), depression, and anxiety to event-free survival during waiting time for heart transplantation in ambulatory patients enrolled in the Waiting for a New Heart Study. METHOD Data from 227 ambulatory patients newly listed for heart transplantation were analyzed. Everyday PA (number of activities, caloric expenditure), depression, and anxiety at time of listing were assessed via questionnaires. Events were defined as death, high-urgency transplantation, delisting due to clinical deterioration, and mechanical circulatory support device implantation. Associations of PA scores, depression, and anxiety with event-free survival were analyzed using Cox proportional hazards models. Covariates included age, sex, body mass index, and objective indicators of disease severity. RESULTS After a median follow-up of 478 days (6-1,849 days), 132 events occurred (46 deaths, 20 mechanical circulatory support device implantations, 54 high-urgency transplantations, 12 delistings). A higher number of activities was significantly associated with a reduced hazard ratio (HR) to experience an event (HR = 0.88, 95% CI [0.81, 0.96]), and depression increased this risk (HR = 1.64, 95% CI [1.16, 2.32]). Both effects remained significant in multivariate analyses (HR = 0.91, 95% CI [0.83, 0.99]; HR = 1.60, 95% CI [1.12, 2.29], ps < .02). No significant interactions between PA scores and emotions were observed and anxiety was unrelated to survival. CONCLUSION Both everyday PA and the absence of depression prolonged event-free survival in ambulatory heart transplant candidates. These findings were independent of objective measures of disease severity. Patients waiting for cardiac transplantation may benefit from interventions focused on increasing their everyday PA and reducing depressive symptoms.

Cardiac Threat Appraisal and Depression after First Myocardial Infarction

The present study investigated cardiac threat appraisal and its association with depression after first myocardial infarction (MI). A semi-structured interview allowing for DSM-IV-axis I diagnoses was administered to 36 patients after first MI. Patients completed self-reports 5–15 days after the MI (time 1), 6–8 weeks later (time 2), and again 6 months later (time 3). Assessments at time 1 included indices of cardiac threat appraisal, locus of control, coping, and depression while at time 2 and time 3 only measures of depression were obtained. Cardiac threat appraisal was significantly correlated with depression at time 1, but was unrelated to depression scores at time 2 and time 3. Furthermore, there was a significant inverse association between cardiac threat appraisal and the subscales “search for affiliation” and “threat minimization” of the coping questionnaire. Additionally, “search for affiliation” correlated negatively with depression scores at time 1 and time 3, and “threat minimization” negatively with depression scores at time 1 and time 2. These results suggest a significant association between cardiac threat appraisal and depressive symptoms shortly after MI. Practical implications for treatment are discussed.