Helen Brown

Physical activity interventions and depression in children and adolescents: a systematic review and meta-analysis

ContextEvidence suggests chronic physical activity (PA) participation may be both protective against the onset of and beneficial for reducing depressive symptoms.ObjectiveThe aim of this article is to assess the impact of PA interventions on depression in children and adolescents using meta-analysis.Data sourcesPublished English language studies were located from manual and computerized searches of the following databases: PsycInfo, The Cochrane Database of Systematic Reviews and The Cochrane Central Register of Controlled Trials, Trials Register of Promoting Health Interventions (TRoPHI; EPPI Centre), Web of Science and MEDLINE.Study selectionStudies meeting inclusion criteria (1) reported on interventions to promote or increase PA; (2) included children aged 5–11xa0years and/or adolescents aged 12–19xa0years; (3) reported on results using a quantitative measure of depression; (4) included a non-physical control or comparison group; and (5) were published in peer-reviewed journals written in English, up to and including May 2011 (when the search was conducted).Data extractionStudies were coded for methodological, participant and study characteristics. Comprehensive Meta-Analysis version-2 software was used to compute effect sizes, with subgroup analyses to identify moderating characteristics. Study quality was assessed using the Delphi technique.ResultsNine studies were included (nxa0=xa0581); most were school-based randomized controlled trials, randomized by individual. Studies used a variety of measurement tools to assess depressive symptoms. The summary treatment effect was small but significant (Hedges’ gxa0=xa0−0.26, standard errorxa0=xa00.09, 95% confidence intervalsxa0=xa0−0.43, −0.08, pxa0=xa00.004). Subgroup analyses showed that methodological (e.g. studies with both education and PA intervention; those with a higher quality score; and less than 3xa0months in duration) and participant characteristics (e.g. single-gender studies; those targeting overweight or obese groups) contributed most to the reduction in depression.ConclusionsThere was a small significant overall effect for PA on depression. More outcome-focused, high-quality trials are required to effectively inform the implementation of programmes to reduce depressive symptoms in children and adolescents.

Does Physical Activity Impact on Presenteeism and Other Indicators of Workplace Well-Being?

The term ‘presenteeism’ is a relatively new concept in workplace health, and has come to signify being at work despite poor health and performing below par. Presenteeism, which is potentially critical to employers, has been associated with a range of psychosocial outcome measures, such as poor mental health and employee well-being. Physical activity is a potential strategy for reducing presenteeism, and for improving the mental health of employees. This article reviews evidence on the relationships between physical activity and employee well-being and presenteeism in the workplace, and identifies directions for research in an emerging field.Electronic and manual literature searches were used to identify 20 articles that met the inclusion criteria. These included 13 intervention trials (8 randomized controlled trials, 5 comparison trials) and 7 observational studies (3 cohort, 4 cross-sectional). Outcome measures were grouped into workplace well-being, psychosocial well-being and physical well-being. Studies measured a wide variety of outcomes, with absenteeism being the most commonly assessed. Evidence indicated a positive association between physical activity and psychosocial health in employees, particularly for quality of life and emotional well-being. However, findings were inconclusive as to the role of physical activity in promoting workplace well-being. Only one study reported on presenteeism, with mixed evidence for outcomes.This article indicates that physical activity and employee psychosocial health are positively related, but there is limited evidence of a relationship between physical activity and presenteeism. A standardized definition of presenteeism and an appropriate evaluation tool are key research priorities if the complex relationships between physical activity and workplace well-being are to be better understood.

Does the use of standing 'hot' desks change sedentary work time in an open plan office?

OBJECTIVEnThis study assessed the use of standing hot desks in an open plan office and their impact on sedentary work time.nnnMETHODnAustralian employees (n=11; 46.9 [9.8] years; BMI 25.9 [3.5 kg/m(2)]) wore an armband accelerometer for two consecutive working weeks (November-December 2010). In the second week, employees were encouraged to use a pod of four standing hot desks to stand and work as often as possible. Desk use was recorded using time logs. The percentages of daily work time spent in sedentary (<1.6 METs), light (1.6-3.0 METs) and moderate+ (>3 METs) intensity categories were calculated for each week, relative to the total daily time at work. Paired sample t tests were used to compare weekly differences.nnnRESULTSnEmployees spent 8:09 ± 0:31h/day at work and hot desk use ranged from zero to 9:35 h for the week. There were no significant changes in mean time spent in sedentary (difference of -0.1%), light (difference of 0.8%) and moderate+ (-0.7%) intensity categories. However, individual changes in sedentary work time ranged from -5.9 to 6.4%.nnnCONCLUSIONSnVolitional use of standing hot desks varied and while individual changes were apparent, desk use did not alter overall sedentary work time in this sample.

Use and monitoring of low dose rituximab in myasthenia gravis

Background Myasthenia gravis is an autoimmune disorder of the neuromuscular junction. Rituximab (RTX), a monoclonal antibody to CD20, leads to B lymphocyte depletion and has been used in some autoimmune disorders, including small case series of myasthenia gravis patients. Methods A retrospective analysis was performed of all patients with acetylcholine receptor (AChR) (11 subjects) or muscle specific kinase antibody (MuSK) positive myasthenia gravis (three subjects), who had been treated with RTX in Brisbane, Australia. In most patients 1u2005g of RTX, in two divided doses, was given. Patients were monitored by serial clinical assessments, flow cytometry of peripheral blood B lymphocytes and antibody testing. Results RTX led to a significant improvement in symptoms in 11 of 14 patients. Doses of immunosuppressive medications were able to be reduced in 12 of 14 patients but medications could be completely ceased in only one patient. A demonstrable reduction of autoantibody levels was found in only three AChR positive patients and one MuSK positive patient, independent of clinical improvement. Peripheral blood B lymphocyte depletion was achieved in 13 out of 14 patients. B lymphocyte recovery occurred between 9 and 30u2005months post RTX (median 12.3u2005months) and was consistently associated with worsening of clinical symptoms. Conclusion Rituximab at a dose of 1u2005g appears to be beneficial in the treatment of patients with severe myasthenia gravis. Serial monitoring of peripheral blood B lymphocytes appears to be useful in guiding the need for further RTX therapy.

Objectively measured sedentary behavior and physical activity in office employees: relationships with presenteeism.

Objective: Employee presenteeism is the extent to which health conditions adversely affect at-work productivity. Given the links between health and activity, this study examined associations between objectively measured physical activity, sedentary behavior, and presenteeism. Methods: Participants were 108 office employees (70% women, mean age 40.7 ± 11.2 years). Activity was measured using ActiGraph GT3X+ accelerometers to determine sedentary (⩽150 counts) and light (151 to 1689 counts) activity; presenteeism with the Work Limitations Questionnaire. Results: Fifty-seven percent of time was spent in sedentary behavior and 38% in light activity. The median Work Limitations Questionnaire Index was 4.38; 6% of participants reported at least moderate impairment. Significant associations were reported for time spent in sedentary behavior before/after work (odds ratio [OR] = 2.58; 95% CI: 1.08 to 6.20) and in light activity, overall (OR = 0.43; 95% CI: 0.19 to 0.97) and during workday lunch hours (OR = 0.34; 95% CI: 0.15 to 0.77), and presenteeism. Conclusions: Future studies should seek greater variation in employee levels of activity and presenteeism to confirm these relationships.

Desk-Based Occupational Sitting Patterns: Weight-Related Health Outcomes

BACKGROUNDnProlonged, uninterrupted sitting time is associated with poor health outcomes. As most sitting time occurs at work, accurate, objective measurement of occupational sitting patterns is required to fully understand its effects on employee health.nnnPURPOSEnThe purpose of this study was to examine associations of desk-based sitting patterns with waist circumference (WC) and BMI.nnnMETHODSnParticipants were full-time, office-based employees (N=105; mean age 40.9±11.5 years; BMI 26.1±3.9; 65% women). Sitting patterns (total desk-based sitting time and number of times employees got up from their desk) were assessed for 5 days using an objective measure of desk-based sitting: the sitting pad. WC, height, and weight were measured, and BMI was calculated. Associations of sitting patterns with WC and BMI were tested using logistic regression models. Data were collected and analyzed in 2011-2012.nnnRESULTSnThose with high levels of sitting time at their desk were 2.7 times (95% CI=1.3, 6.3) more likely to have WC ≥94 cm (men) and ≥80 cm (women), and 9.0 times (95% CI=1.9, 41.9) more likely to have BMI ≥30 than those with lower sitting time. There were no associations between the number of times employees got up from sitting at their desk and WC or BMI.nnnCONCLUSIONSnHigh levels of desk-based sitting time were associated with an increased likelihood of negative weight-related health outcomes, whereas frequency of getting up from sitting at the desk was not.

Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke

BACKGROUND Intravenous infusion of alteplase is used for thrombolysis before endovascular thrombectomy for ischemic stroke. Tenecteplase, which is more fibrin‐specific and has longer activity than alteplase, is given as a bolus and may increase the incidence of vascular reperfusion. METHODS We randomly assigned patients with ischemic stroke who had occlusion of the internal carotid, basilar, or middle cerebral artery and who were eligible to undergo thrombectomy to receive tenecteplase (at a dose of 0.25 mg per kilogram of body weight; maximum dose, 25 mg) or alteplase (at a dose of 0.9 mg per kilogram; maximum dose, 90 mg) within 4.5 hours after symptom onset. The primary outcome was reperfusion of greater than 50% of the involved ischemic territory or an absence of retrievable thrombus at the time of the initial angiographic assessment. Noninferiority of tenecteplase was tested, followed by superiority. Secondary outcomes included the modified Rankin scale score (on a scale from 0 [no neurologic deficit] to 6 [death]) at 90 days. Safety outcomes were death and symptomatic intracerebral hemorrhage. RESULTS Of 202 patients enrolled, 101 were assigned to receive tenecteplase and 101 to receive alteplase. The primary outcome occurred in 22% of the patients treated with tenecteplase versus 10% of those treated with alteplase (incidence difference, 12 percentage points; 95% confidence interval [CI], 2 to 21; incidence ratio, 2.2; 95% CI, 1.1 to 4.4; P=0.002 for noninferiority; P=0.03 for superiority). Tenecteplase resulted in a better 90‐day functional outcome than alteplase (median modified Rankin scale score, 2 vs. 3; common odds ratio, 1.7; 95% CI, 1.0 to 2.8; P=0.04). Symptomatic intracerebral hemorrhage occurred in 1% of the patients in each group. CONCLUSIONS Tenecteplase before thrombectomy was associated with a higher incidence of reperfusion and better functional outcome than alteplase among patients with ischemic stroke treated within 4.5 hours after symptom onset. (Funded by the National Health and Medical Research Council of Australia and others; EXTEND‐IA TNK ClinicalTrials.gov number, NCT02388061.)

Measuring presenteeism: which questionnaire to use in physical activity research?

BACKGROUNDnAdults with arthritis can benefit from participation in physical activity and may be assisted by organized programs. The purpose of this study was to evaluate the effectiveness of a 20-week behavioral lifestyle intervention, Active Living Every Day (ALED), for improvements in primary outcomes (physical activity levels, aerobic endurance, function, symptoms).nnnMETHODSnA 20-week randomized controlled community trial was conducted in 354 adults. Outcomes were assessed at baseline and 20 weeks in the intervention and wait-list control groups. The intervention group was also assessed at 6 and 12 months. Mean outcomes were determined by multilevel regression models in the intervention and control groups at follow-up points.nnnRESULTSnAt 20 weeks, the intervention group significantly increased participation in physical activity, and improved aerobic endurance, and select measures of function while pain, fatigue and stiffness remained status quo. In the intervention group, significant improvements in physical activity at 20 weeks were maintained at 6 and 12 months, and stiffness decreased.nnnCONCLUSIONSnALED appears to improve participation in physical activity, aerobic endurance, and function without exacerbating disease symptoms in adults with arthritis.BACKGROUNDnAn emerging area of interest in workplace health is presenteeism; the measurable extent to which physical or psychosocial symptoms, conditions and disease adversely affect the work productivity of those who choose to remain at work. Given established links between presenteeism and health, and health and physical activity, presenteeism could be an important outcome in workplace physical activity research. This study provides a narrative review of questionnaires for use in such research.nnnMETHODSnEight self-report measures of presenteeism were identified. Information regarding development, constructs measured and psychometric properties was extracted from relevant articles.nnnRESULTSnQuestionnaires were largely self-administered, had 4-44 items, and recall periods ranging from 1 week to 1 year. Items were identified as assessing work performance, physical tolerance, psychological well-being and social or role functioning. Samples used to test questionnaires were predominantly American male employees, with an age range of 30-59 years. All instruments had undergone psychometric assessment, most commonly discriminant and construct validity.nnnCONCLUSIONnBased on instrument characteristics, the range of conceptual foci covered and acceptable measurement properties, the Health and Work Questionnaire, Work Ability Index, and Work Limitations Questionnaire are suggested as most suitable for further exploring the relationship between physical activity and presenteeism.

Are We Chained to Our Desks? Describing Desk-Based Sitting Using a Novel Measure of Occupational Sitting

BACKGROUNDnProlonged occupational sitting is related to poor health outcomes. Detailed data on sitting time at desks are required to understand and effectively influence occupational sitting habits.nnnMETHODSnFull-time office employees were recruited (n = 105; mean age 40.9 ± 11.5 years; BMI 26.1 ± 3.9, 65% women). Sitting at the desk and in other work contexts was measured using a sitting pad and ActivPAL for an entire working week. Employees used a diary to record work hours. Time spent at work, sitting at work and at the desk; number of sit to stand transitions at the desk; and number of bouts of continuous sitting at the desk < 20 and > 60 minutes, were calculated.nnnRESULTSnAverage time spent at work was 8.7 ± 0.8 hours/day with 67% spent sitting at the desk (5.8 ± 1.2 hours/day), and 4% in other workplace settings. On average, employees got up from their desks 3 times/hour (29 ± 13/day). Sitting for more than 60 consecutive minutes occurred infrequently (0.69 ± 0.62 times/day), with most sit to stands (80%; 23 ± 14) occurring before 20 minutes of continual sitting.nnnCONCLUSIONnThe findings provide highly detailed insights into desk-based sitting habits, highlighting large proportions of time spent sitting at desks, but with frequent interruptions.

Tenecteplase versus alteplase before endovascular thrombectomy (EXTEND-IA TNK): A multicenter, randomized, controlled study

Background and hypothesis Intravenous thrombolysis with alteplase remains standard care prior to thrombectomy for eligible patients within 4.5u2009h of ischemic stroke onset. However, alteplase only succeeds in reperfusing large vessel arterial occlusion prior to thrombectomy in a minority of patients. We hypothesized that tenecteplase is non-inferior to alteplase in achieving reperfusion at initial angiogram, when administered within 4.5u2009h of ischemic stroke onset, in patients planned to undergo endovascular therapy. Study design EXTEND-IA TNK is an investigator-initiated, phase II, multicenter, prospective, randomized, open-label, blinded-endpoint non-inferiority study. Eligibility requires a diagnosis of ischemic stroke within 4.5u2009h of stroke onset, pre-stroke modified Rankin Scale≤3 (no upper age limit), large vessel occlusion (internal carotid, basilar, or middle cerebral artery) on multimodal computed tomography and absence of contraindications to intravenous thrombolysis. Patients are randomized to either IV alteplase (0.9u2009mg/kg, max 90u2009mg) or tenecteplase (0.25u2009mg/kg, max 25u2009mg) prior to thrombectomy. Study outcomes The primary outcome measure is reperfusion on the initial catheter angiogram, assessed as modified treatment in cerebral infarction 2u2009b/3 or the absence of retrievable thrombus. Secondary outcomes include modified Rankin Scale at day 90 and favorable clinical response (reduction in National Institutes of Health Stroke Scale by ≥8 points or reaching 0–1) at day 3. Safety outcomes are death and symptomatic intracerebral hemorrhage. Trial registration ClinicalTrials.gov NCT02388061