Helen E. Reid

Randomized Controlled Trial of Calcium Supplementation in Healthy, Nonosteoporotic, Older Men

BACKGROUND There is no consistent evidence, to our knowledge, that calcium supplementation affects bone mineral density (BMD) in men, despite male osteoporosis being a common clinical problem. METHODS To determine the effects of calcium supplementation (600 mg/d, 1200 mg/d, or placebo) on BMD in men, we conducted a double-blind, randomized controlled trial for a 2-year period at an academic clinical research center. A total of 323 healthy men at least 40 years old (mean age, 57 years) were recruited by newspaper advertisement. Complete follow-up was achieved in 96% of subjects. RESULTS The BMD increased at all sites in the group receiving calcium, 1200 mg/d, by 1% to 1.5% more than those receiving placebo. The results for the group receiving calcium, 600 mg/d, were not different from the placebo group at any BMD site. There was no interaction between the BMD treatment effect and either age or dietary calcium intake. There were dosage-related, sustained decreases in serum parathyroid hormone (P < .001), total alkaline phosphatase activity (P = .01), and procollagen type 1 N-terminal propeptide (P < .001) amounting to 25%, 8%, and 20%, respectively, in the group receiving calcium, 1200 mg/d, at 2 years. Tooth loss, constipation, and cramps were unaffected by calcium supplementation, falls tended to be less frequent in the group receiving calcium, 1200 mg/d, but vascular events tended to be more common in the groups receiving calcium vs the group receiving placebo. CONCLUSION Calcium, 1200 mg/d, has effects on BMD in men comparable with those found in postmenopausal women but a dosage of 600 mg/d is ineffective for treating BMD. TRIAL REGISTRATION actr.org.au Identifier: 012605000274673.

Effects of calcium supplementation on lipids, blood pressure, and body composition in healthy older men: a randomized controlled trial

BACKGROUND Calcium supplementation has been suggested to have beneficial effects on serum lipids, blood pressure, and body weight, but these possibilities have not been rigorously assessed in men. OBJECTIVE This study evaluated the effect of calcium supplementation on the change in the ratio of HDL to LDL cholesterol (primary endpoint) and on changes in cholesterol fractions, triglycerides, blood pressure, and body composition (secondary endpoints). DESIGN We carried out a randomized controlled trial of calcium supplementation in 323 generally healthy men over a period of 2 y. Subjects were randomly assigned to take placebo, 600 mg Ca/d, or 1200 mg Ca/d. RESULTS There was no significant treatment effect on the ratio of HDL to LDL cholesterol (P = 0.47) nor on weight, fat mass, lean mass, triglycerides, or total, LDL, or HDL cholesterol (P > 0.28 for all). There were downward trends in systolic and diastolic blood pressures within the calcium-supplemented groups, but there were no significant treatment effects over the whole trial period (P > 0.60). In a post hoc analysis of those with baseline calcium intakes below the median value (785 mg/d), blood pressures showed borderline treatment effects (P = 0.05-0.06 for changes at 2 y in those who received 1200 mg Ca/d compared with placebo: systolic, -4.2 mm Hg; diastolic, -3.3 mm Hg). Low magnesium intake showed a similar interaction. No treatment effects on weight or body composition were found. CONCLUSIONS These data do not show significant effects of calcium supplementation on serum lipids or body composition. Calcium supplementation in those with low dietary intakes may benefit blood pressure control. This trial was registered with the Australian Clinical Trials Registry as ACTRN 012605000274673.

MEASURES OF PHYSICAL HETEROGENEITY IN APPRAISAL OF GEOMORPHIC RIVER CONDITION FOR URBAN STREAMS: TWIN STREAMS CATCHMENT, AUCKLAND, NEW ZEALAND

This investigation created and tested a template to rapidly assess geomorphic river condition in urban settings. This extension to the River Styles Framework® (Brierley and Fryirs, 2005) entailed mapping the heterogeneity in bed material, habitat, and flow characteristics for different types of rivers, integrating parameters from geomorphology, ecology, and hydrology. Analysis was carried out at 27 sites in the Twin Streams catchment in West Auckland, New Zealand. The method successfully recorded the extent of degradation of physical structure following European settlement of the catchment. With the exception of one subcatchment, streams were found to be largely intact in the headwaters. Many of these headwater streams were found to be of exceptional quality, with high physical heterogeneity. Geomorphic condition is more degraded in downstream areas. Fine-grained sediment has smothered stream courses in the lower half of the catchment, covering bed material and creating homogenous structure and flow, decreasing quality of habitat for biota. In this more urbanized area, with more stormwater drains, riparian vegetation is limited and of poor to moderate quality. Understanding of geomorphic responses to human disturbance is critical in the design and implementation of effective management strategies that seek to improve the ecological condition of urban streams.

Influence of bed heterogeneity and habitat type on macroinvertebrate uptake in peri-urban streams

Abstract The role of geomorphic structure, referred to as physical heterogeneity, and its influence upon the colonization of habitat by macroinvertebrates was analysed in the peri-urban, Twin Streams Catchment, in West Auckland, New Zealand. Using a cross-scalar approach, 4 riffle-run assemblages were analysed in each of 2 River Styles (a confined, low sinuosity, gravel bed river and a partly confined, low sinuosity, bedrock, cobble, and gravel bed river). Each of these 8 locations comprised 2 distinct sampling areas; the upstream zone had a more heterogeneous river bed with a high diversity of physical features and flow, whilst the downstream area had a more homogeneous structure. Microhabitat features sampled at each site included streambed material, bank margins, fine grained organic debris, wood, and boulders. Habitat mosaics and their associated macroinvertebrate relationships followed a semi-predictable but interrupted pattern, supporting the view that river systems are a patchy discontinuum. Homogeneous zones were more frequently characterised by higher proportions of Trichoptera than heterogeneous zones, whilst heterogeneous zones were frequently characterised by Plecoptera and Ephemeroptera . Diversity was maximised when the species pools from heterogeneous and homogeneous sites were combined for any given site. Functional habitats influenced macroinvertebrate assemblages in non-linear and complex ways. Wood and organic debris habitats were associated with high diversity, abundance, and sensitive species whereas streambed habitat was usually associated with low diversity. A diverse range of physical zones that approximates the ‘natural range of behaviour’ for the given type of stream was considered to provide a more effective platform for rehabilitation planning than emphasising heterogeneity of physical structure in its own right.

RIVER RECOVERY IN AN URBAN CATCHMENT: TWIN STREAMS CATCHMENT, AUCKLAND, NEW ZEALAND

This study examines the evolution of a small urbanizing catchment in Waitakere City, New Zealand over the period since European settlement. Geomorphic changes are interpreted from the use of historical documents complemented by sediment analysis at eight sites throughout the catchment. Differing forms and rates of geomorphic adjustment are characterized for five different types of stream. Reach sensitivity to change and trajectory of change are related to the capacity for adjustment of differing stream types and their position within the catchment. These relationships are analyzed using the recovery diagram developed by Fryirs and Brierley (2000). Profound disturbance has been experienced, and streams have responded to a series of land use changes over a relatively short time frame (around 160 years). The system responded quickly to forest clearance and subsequent phases of pasture, horticulture, viticulture, and urbanization. Significant geomorphic recovery is under way along most stream courses. While substantial increases in sediment yield are inferred, the fine-grained nature of these deposits has not significantly altered geomorphic features of headwater streams. In mid-catchment, benches have developed along overwidened channels. Prospects for geomorphic recovery are much more limited along lowland reaches, where cumulative impacts have brought about significant changes to river morphology, such that recovery to predisturbance conditions is no longer a realistic prospect over management time frames (50-100 years). The relative geomorphic resilience of this urbanizing catchment is considered to reflect the geologic imprint upon this landscape (a dissected volcano), the reforestation of headwater reaches within a short interval of initial clearance, and the location of urban impacts that are concentrated in the lower part of the river system.

The role of landscape setting in minimizing hydrogeomorphic impacts of flow regulation

Abstract The Tongariro Power Development Scheme (TPDS) is used to regulate flow in the headwaters of the largest catchment on the North Island of New Zealand (the Waikato). Two small dams, the Rangipo Dam and the Poutu Intake Dam, were constructed in 1973 and 1983. The flow regime of the river is managed to divert freshes into the power scheme, but allows flows larger than 100 m 3 s −1 to be released, to rework and transport sediment through the catchment. Analysis of aerial photos and maps spanning 1928 to 2007, alongside field measurements, show that there have been few hydrogeomorphic adjustments since dam construction. This includes limited changes to channel geometry, channel planform and bed material organization immediately downstream of the dams. In addition, offsite effects are minimal, both 500 m downstream of each dam, and in the more sensitive, less confined reaches in the lower catchment (11 km downstream of the Poutu Intake dam). The limited changes can be attributed to the locations of the dams within reaches characterised by bedrock gorges and confined within terraces. These locations act to flush sediments and impose margins that allow minimal adjustment of the channel. Bed material within this reach is characterised by the presence of a boulder lag. This is sourced from long-term incision into lahar deposits, and acts to limit the rate of incision, creating a steep and stable base upon which active fractions are transported. Just as importantly, significant storage in the low-relief volcanic plateau located in the upper catchment acts to disconnect and store the high sediment yields generated by active volcanic cones in the western sub-catchment upstream of the dams. This limits the rate of sediment supply to regulated reaches. Findings from this study show that analysis of reach-scale controls is essential in framing dam site locations in relation to the distribution of reaches and landscape units across the catchment. In this instance, tributary inputs downstream of the dams do not replenish the sediment and flow removed at the dam locations, as has been observed in other regulated systems. Rather, the river itself is resilient to change and flow variability is well managed allowing geomorphically effective floods to occur. Landscape setting is a key consideration in determining the hydrogeomorphic impact of flow regulation.