Helen M. Ranney

FILTER‐PAPER ELECTROPHORESIS OF MOUSE HAEMOGLOBIN: PRELIMINARY NOTE

Studies of the electrophoretic haemoglobin patterns in inbred strains of mice have shown two different types of patterns. In three strains, all mice tested had one type of pattern; in five, another type of pattern was found in all animals tested; and in three strains, individual mice showed either one or the other haemoglobin pattern. These data strongly indicate a genetic basis of haemoglobin differences in mice. Further work is needed to determine the exact nature of this genetic basis.

THE HEREDITARY TRANSMISSION OF HEMOGLOBIN DIFFERENCES IN MICE

The existence, in inbred strains of mice, of two different types of electrophoretic hemoglobin patterns has been demonstrated with the method of paper electrophoresis (1). Preliminary studies of the distribution of these different patterns in the inbred strains tested indicated strongly a genetic basis of hemoglobin differences in mice. It is the purpose of the present communication to report the results of breeding experiments designed to test the assumption of a hereditary transmission of these differences and to determine the mode of inheritance.

STUDIES OF THE INCORPORATION OF Fe59 INTO NORMAL AND ABNORMAL HEMOGLOBINS

This study was undertaken to ascertain whether different normal and abnormal hemoglobin components exhibit different rates of Fe59 incorporation in human subjects and in experimental animals. The hemoglobin of normal man contains minor components, hemoglobins A2 and A3, in addition to the principal component, hemoglobin A1. Patients with hereditary hemoglobin abnormalities have relatively large amounts of abnormal hemoglobins; electrophoretic analysis of the hemoglobin of many experimental animals reveals a