Helen P. Kavitha

Isolation, Characterization and Anti-Inflammatory Property of Thevetia Peruviana

Thevetia peruviana seeds contain glucosides of neriifolin, acetylneriifolin and thevetin. Seed oil distillates of Thevetia peruviana have been found to contain anti-bacterial activity. In the persent work, the fresh flowers of Thevetia peruviana was subjected to phytochemical studies. The results of the study showed that the flowers contain quercetin, kaempferol and quercetin-7-o-galactoside. The structure of the isolated compound was characterized by UV, 1 H NMR and 13 C NMR spectra. The anti-inflammatory character of the isolated compound was tested by in vitro method and the results of the study revealed that the isolated compound showed a biphasic property.

Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles

2 The present work deals with the synthesis of some novel heterocyclic compounds such as benzoxazoles , 7, 13 and 19, imidazoles 3, 8, 14 and 20, benzimidazoles 4, 9, 15 and 21, and tetrazoles 10, 16, and 22. The synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The compounds were evaluated for cytotoxicity against human cancer cell lines such as MCF-7 (breast cancer) and HT-29 (colon cancer) by the MTT assay method. Among the tested compounds, 4,4’-sulfonylbis(N-(2-(1H-benzo[d]imidazol- -2-yl)ethyl)aniline (9), N-bis(2-(benzo[d]oxazol-2-yl)-ethyl)- 6-phenyl-1,3,5-triazine-2,4-diamine (13), N-bis(2-(1H-benzo[ d]imidazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (15) and N-tris(2-1H-benzo[d]imidazol-2-yl)ethyl)- 1,3,5-triazine-2,4,6-triamine (21) showed potent cytotoxicity.

2-Phenyl-4H-3,1-benzoxazin-4-one

The title molecule, C14H9NO2, is nearly planar with a dihedral angle of 3.72 (4)° beteewn the plane of the phenyl ring and the 3,1-benzoxazin-4-one fragment. The molecules are arranged into stacks parallel to the b axis via π–π stacking interactions [centroid-centroid distance = 4.2789 (11) Å] and the crystal packing is additionally stabilized by weak intermolecular C—H⋯O interactions.

2-(4-Bromo­phen­yl)-3-(4-hy­droxy­phen­yl)-1,3-thia­zolidin-4-one

In the title compound, C15H12BrNO2S, the dihedral angle between the two aromatic rings is 87.81 (8)°. The five-membered thiazolidine ring has an envelope conformation, with the S atom displaced by 0.4545 (7) Å from the mean plane of the other four ring atoms. The crystal structure exhibits O—H⋯O, C—H⋯O, C—H⋯Br and C—H⋯ π interactions.

2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

This present work aims at synthesizing a novel tetrazole from quinazolinone. 3-(4-Aminophenyl)-2-methyl-3H-quinazolin-4-one is converted into a nitrile by reacting it with acrylonitrile and triton B. The nitrile on treatment with NaN3, NH4Cl and DMF yielded the corresponding tetrazole. The tetrazole obtained was characterized by IR, 1H NMR, EI-MS and elemental analysis. The compound was screened for antimicrobial activity against Staphylococcus aureus, Escherichia coli, Candida albicans and Aspergillus niger.The results of the study show that the compound possesses fairly good antimicrobial activity against the test organisms.

(E)-4-[(4-Bromo­benzyl­idene)amino]phenol

In the title compound, C13H10BrNO, the dihedral angle between the benzene rings is 35.20 (8)°. In the crystal, molecules are linked by O—H⋯N hydrogen bonds, forming a zigzag chain along the a axis. A weak C—H⋯π interaction is observed between the chains.

3-Amino-phenyl naphthalene-1-sulfonate.

In the title compound, C16H13NO3S, the plane of the naphthalene ring system forms a dihedral angle of 64.66 (10)° with the benzene ring. The molecular structure is stabilized by weak intramolecular C—H⋯O interactions and the crystal packing is stabilized by weak intermolecular N—H⋯O and C—H⋯O interactions and by π–π stacking interactions of the inversion-related naphthalene units [centroid–centroid distance of 3.7373 (14) Å].

Phenyl naphthalene-2-sulfonate.

In the crystal structure of the title compound, C16H12O3S, the dihedral angle between the naphthalene ring system and the phenyl ring is 65.21 (3)°. The molecules are linked by intermolecular C—H⋯O hydrogen bonds, forming a chain along the a axis. The chains are connected through weak C—H⋯π interactions.

2-Chloro-4,6-bis-(piperidin-1-yl)-1,3,5-triazine.

The title compound, C13H20ClN5, crystallizes with two molecules in the asymmetric unit. The piperidine rings in both molecules adopt chair conformations. Weak π–π interactions [centroid–centroid distance = 3.9815 (8) Å] are observed in the crystal structure.

Synthesis of 4-[10H-Phenothiazin-10-yl(1H-tetrazol-5-yl)-methyl]phenol

This present work aims at synthesizing a novel tetrazole from phenothiazine. Phenothiazine is converted into a nitrile by reacting it with 4-hydroxybenzaldehyde, sodium metabisulphite and sodium cyanide. The nitrile on treatment with NaN3/DMF yielded the corresponding tetrazole. The tetrazole obtained was characterized by IR, 1H NMR, EI-MS and elemental analysis.