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Dive into the research topics where Helen Vlassara is active.

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Featured researches published by Helen Vlassara.


Neurobiology of Aging | 1996

Glycation and microglial reaction in lesions of Alzheimer's disease

Dennis W. Dickson; Stefano Sinicropi; Shu Hui Yen; Li Wen Ko; L. A. Mattiace; Richard Bucala; Helen Vlassara

Single, double, and triple immunostaining of cryostat sections of elderly normal and Alzheimer disease (AD) brain was performed with monoclonal and polyclonal antibodies to advanced glycation end products (AGE). The sections were counterstained with thioflavin-S or with immunocytochemistry for A beta and also stained with markers for microglia. AGE-immunoreactivity was detected in senile plaques and neurofibrillary tangles (NFT). AGE immunoreactivity was most intense in dense or reticular amyloid deposits and extracellular NFT, while intracellular NFT and diffuse amyloid had less AGE immunoreactivity. This pattern of immunoreactivity was similar to that noted in previous studies with antibodies to apolipoprotein-E (apo-E). Therefore, double labeling with antibodies to apo-E and AGE was performed. AGE immunoreactivity colocalized to a very high degree with apo-E immunoreactivity, except that relatively more intense apo-E immunoreactivity was detected in amyloid deposits and more intense AGE immunoreactivity in NFT. The lesions that were immunostained with antibodies to AGE and apo-E were often, but not always, associated with a local microglial reaction. The results raise the possibility that apo-E or a fragment of apo-E may be glycated. Biochemical studies are needed to determine the extent of possible apo-E glycation in AD. The present results raise the possibility that glycation may serve as one of the signals for activation of microglia associated with amyloid deposits and extracellular NFT.


Archive | 1995

Compositions and methods for stimulating amyloid removal in amyloidogenic diseases using advanced glycosylation endproducts

Michael P. Vitek; Anthony Cerami; Richard J. Bucala; Peter C. Ulrich; Helen Vlassara; Xini Zhang


Archive | 1995

Compositions and methods for advanced glycosylation endproduct-mediated modulation of amyloidosis

Michael P. Vitek; Anthony Cerami; Richard J. Bucala; Peter C. Ulrich; Helen Vlassara; Xini Zhang


Archive | 1993

Glycosylation of lipids and lipid-containing particles, and diagnostic and therapeutic methods and materials derived therefrom

Richard J. Bucala; Helen Vlassara; Anthony Cerami


Archive | 1995

Methods and materials for the diagnosis and treatment of conditions such as stroke

Richard J. Bucala; Helen Vlassara; Anthony Cerami; Kevin J. Tracey


Archive | 1996

Agents for binding to advanced glycosylation endproducts, and methods of their use

Yong Ming Li; Helen Vlassara; Anthony Cerami


Archive | 1998

Methods for treatment predicated on the presence of advanced glycosylation endproducts in tobacco and its combustion byproducts

Richard J. Bucala; Helen Vlassara; Anthony Cerami; Carla J. Cerami; Henry W. Founds


Archive | 1996

Compositions and devices for partitioning advanced glycosylation endproducts, and methods of their use

Yong Ming Li; Helen Vlassara; Anthony Cerami


Archive | 1995

Methods for detecting the presence of advanced glycosylation endproducts

Yong Ming Li; Helen Vlassara; Anthony Cerami


Archive | 1995

Methods for inhibiting the cross-linking of advanced glycosylation endproducts

Yong Ming Li; Helen Vlassara; Anthony Cerami

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Richard J. Bucala

Queen's University Belfast

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Yong Ming Li

École Polytechnique Fédérale de Lausanne

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Xini Zhang

École Polytechnique Fédérale de Lausanne

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Cijiang He

Icahn School of Medicine at Mount Sinai

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L. A. Mattiace

Albert Einstein College of Medicine

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