Hélène Perrin

Ultracold atoms confined in rf-induced two-dimensional trapping potentials

We present the experimental implementation of a new trap for cold atoms proposed by O. Zobay and B. M. Garraway (Phys. Rev. Lett. 86 (2001) 1195). It relies on adiabatic potentials for atoms dressed by a rf field in an inhomogeneous magnetic field. This trap is well suited to confine atoms tightly along one direction to produce a two-dimensional atomic gas. We transferred ultracold atoms into this trap, starting either from thermal samples or Bose-Einstein condensates. In the latter case, technical noise during the loading stage caused heating and prevented us from observing 2D BECs.

Ring trap for ultracold atoms

We propose a toroidal trap designed for ultracold atoms. It relies on a combination of a magnetic trap for rf-dressed atoms, which creates a bubble-like trap, and a standing wave of light. This trap is well-suited for investigating questions of low dimensionality in a ring potential. We study the trap characteristics for a set of experimentally accessible parameters. A loading procedure from a conventional magnetic trap is also proposed. The flexible nature of this ring trap, including an adjustable radius and adjustable transverse oscillation frequencies, will allow the study of superfluidity in variable geometries and dimensionalities.

Tailored immunity by skin antigen-presenting cells

Skin vaccination aims at targeting epidermal and dermal antigen-presenting cells (APCs), indeed many subsets of different origin endowed with various functions populate the skin. The idea that the skin could represent a particularly potent site to induce adaptive and protective immune response emerged after the success of vaccinia virus vaccination by skin scarification. Recent advances have shown that multiple subsets of APCs coexist in the skin and participate in immunity to infectious diseases. Induction of an adaptive immune response depends on the initial recognition and capture of antigens by skin APCs and their transport to lymphoid organs. Innovative strategies of vaccination have thus been developed to target skin APCs for tailored immunity, hence this review will discuss recent insights into skin APC subsets characterization and how they can shape adaptive immune responses.

Example of a Quantum Anomaly in the Physics of Ultracold Gases

In this Letter, we propose an experimental scheme for the observation of a quantum anomaly--quantum-mechanical symmetry breaking--in a two-dimensional harmonically trapped Bose gas. The anomaly manifests itself in a shift of the monopole excitation frequency away from the value dictated by the Pitaevskii-Rosch dynamical symmetry [L. P. Pitaevskii and A. Rosch, Phys. Rev. A 55, R853 (1997)]. While the corresponding classical Gross-Pitaevskii equation and the hydrodynamic equations derived from it do exhibit this symmetry, it is--as we show in our paper--violated under quantization. The resulting frequency shift is of the order of 1% of the carrier, well in reach for modern experimental techniques. We propose using the dipole oscillations as a frequency gauge.

A two-dimensional quantum gas in a magnetic trap

We present the first experimental realization of a two-dimensional quantum gas in a purely magnetic trap dressed by a radio frequency field in the presence of gravity. The resulting potential is extremely smooth and very close to harmonic in the two-dimensional plane of confinement. We fully characterize the trap and demonstrate the confinement of a quantum gas to two dimensions. The trap geometry can be modified to a large extent, in particular in a dynamical way. Taking advantage of this possibility, we study the monopole and the quadrupole modes of a two-dimensional Bose gas.

CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.

Muscle injury triggers inflammation in which infiltrating mononuclear phagocytes are crucial for tissue regeneration. The interaction of the CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axis that guides phagocyte infiltration is incompletely understood. Here, we show that CX3CR1 deficiency promotes muscle repair and rescues Ccl2−/− mice from impaired muscle regeneration as a result of altered macrophage function, not infiltration. Transcriptomic analysis of muscle mononuclear phagocytes reveals that Apolipoprotein E (ApoE) is upregulated in mice with efficient regeneration. ApoE treatment enhances phagocytosis by mononuclear phagocytes in vitro, and restores phagocytic activity and muscle regeneration in Ccl2−/− mice. Because CX3CR1 deficiency may compensate for defective CCL2-dependant monocyte recruitment by modulating ApoE-dependent macrophage phagocytic activity, targeting CX3CR1 expressed by macrophages might be a powerful therapeutic approach to improve muscle regeneration.

Critical rotation of an annular superfluid Bose-Einstein condensate

We analyze the excitation spectrum of a superfluid Bose-Einstein condensate rotating in a ring trap. We identify two important branches of the spectrum related to outer and inner edge surface modes that lead to the instability of the superfluid. Depending on the initial circulation of the annular condensate, either the outer or the inner modes become first unstable. This instability is crucially related to the superfluid nature of the rotating gas. In particular, we point out the existence of a maximal circulation above which the superflow decays spontaneously, which cannot be explained by invoking the average speed of sound.

Recent developments in trapping and manipulation of atoms with adiabatic potentials

A combination of static and oscillating magnetic fields can be used to ‘dress’ atoms with radio-frequency (RF), or microwave, radiation. The spatial variation of these fields can be used to create an enormous variety of traps for ultra-cold atoms and quantum gases. This article reviews the type and character of these adiabatic traps and the applications which include atom interferometry and the study of low-dimensional quantum systems. We introduce the main concepts of magnetic traps leading to adiabatic dressed traps. The concept of adiabaticity is discussed in the context of the Landau–Zener model. The first bubble trap experiment is reviewed together with the method used for loading it. Experiments based on atom chips show the production of double wells and ring traps. Dressed atom traps can be evaporatively cooled with an additional RF field, and a weak RF field can be used to probe the spectroscopy of the adiabatic potentials. Several approaches to ring traps formed from adiabatic potentials are discussed, including those based on atom chips, time-averaged adiabatic potentials and induction methods. Several proposals for adiabatic lattices with dressed atoms are also reviewed.

RF spectroscopy in a resonant RF-dressed trap

We study the spectroscopy of atoms dressed by a resonant radiofrequency (RF) field inside an inhomogeneous magnetic field and confined in the resulting adiabatic potential. The spectroscopic probe is a second, weak, RF field. The observed line shape is related to the temperature of the trapped cloud. We demonstrate evaporative cooling of the RF-dressed atoms by sweeping the frequency of the second RF field around the Rabi frequency of the dressing field.

Imaging the collective excitations of an ultracold gas using statistical correlations

Advanced data analysis techniques have proved to be crucial for extracting information from noisy images. Here we show that principal component analysis can be successfully applied to ultracold gases to unveil their collective excitations. By analyzing the correlations in a series of images we are able to identify the collective modes which are excited, determine their population, image their eigenfunction, and measure their frequency. Our method allows us to discriminate the relevant modes from other noise components and is robust with respect to the data sampling procedure. It can be extended to other dynamical systems, including cavity polariton quantum gases and trapped ions.