Hélène Poirson
French Institute of Health and Medical Research
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Gastroenterologie Clinique Et Biologique | 2006
Jean-Marie Péron; Jean-Michel Mansuy; Hélène Poirson; Christophe Bureau; Emmanuel Dupuis; Laurent Alric; Jacques Izopet; Jean-Pierre Vinel
OBJECTIVES Hepatitis E virus (HEV) is responsible for acute hepatitis predominantly in developing countries. In Western Europe and in the US, cases of acute HEV infection are uncommon and occur primarily in travelers returning from endemic countries. The aim of this study was to describe patients with acute hepatitis E in South West France and compare them with patients with acute hepatitis A. METHODS 23 consecutive patients over 13 months were analysed. Acute hepatitis E was diagnosed on the presence of specific serum antibodies or viral RNA detection in serum or stools. Real time PCR products from viraemic patients were sequenced. RESULTS All the HEV sequences belonged to genotype 3. Two patients (8%) died during their hospital stay, both suffered from severe underlying disease. Only 3 patients (13%) had travelled outside of Europe, within 3 months of the onset of disease. When compared to 23 patients with acute hepatitis A at the same hospital and during the same time frame, HEV-infected patients were older (54.4 +/- 16.6 vs 24.5 +/- 16.6, P<0.05), had lower ALT levels (55.4 X upper normal limit +/- 48.6 vs 107.8 X upper normal limit +/- 82.8, P<0.05) and had lower incidence of recent travel outside of Europe (13% in the hepatitis E group vs 60% in the hepatitis A group, P<0.05). CONCLUSIONS Hepatitis E can be considered an autochthonous infection in South West France. All strains sequenced were related to genotype III. When compared to hepatitis A, HEV-infected patients were older, had lower ALT levels and had a lower incidence of travel outside of Europe.
Journal of Medical Virology | 2004
Jean Michel Mansuy; Jean Marie Peron; Florence Abravanel; Hélène Poirson; Martine Dubois; Marcel Miedouge; Françoise Vischi; Laurent Alric; Jean Pierre Vinel; Jacques Izopet
Journal of Gastroenterology and Hepatology | 2006
Jean-Marie Péron; Jean-Michel Mansuy; Christian Recher; Christophe Bureau; Hélène Poirson; Laurent Alric; Jacques Izopet; Jean-Pierre Vinel
Gastroenterologie Clinique Et Biologique | 2003
Christophe Bureau; Hélène Poirson; Jean-Marie Péron; Jean-Pierre Vinel
Hepatology | 2003
Hélène Poirson; Jean Marie Peron; Laurent Alric; Christophe Bureau; Sophie Metivier; Emmanuel Dupuis; Jacques Izopet; Jean-Pierre Vinel
Gastroenterologie Clinique Et Biologique | 2005
Jean-Marie Péron; Jean-Michel Mansuy; Hélène Poirson; Christophe Bureau; Jacques Izopet; Jean-Pierre Vinel
Gastroenterologie Clinique Et Biologique | 2005
Jean-Marie Péron; Jean-Michel Mansuy; Hélène Poirson; Christophe Bureau; Jacques Izopet; Jean-Pierre Vinel
Gastroenterologie Clinique Et Biologique | 2009
Jean-Marie Péron; Jean-Michel Mansuy; Christian Recher; C. Merviel; Christophe Bureau; Emmanuel Dupuis; Sophie Metivier; Hélène Poirson; Karl Barange; Laurent Alric; Louis Buscail; Jean-Pierre Vinel; Jacques Izopet
Gastroenterologie Clinique Et Biologique | 2009
Jean Marie Peron; Jean Michel Mansuy; Christian Recher; C. Merviel; Christophe Bureau; Emmanuel Dupuis; Sophie Metivier; Hélène Poirson; Karl Barange; Laurent Alric; Louis Buscail; Jean Pierre Vinel; Jacques Izopet
/data/revues/03998320/00300005/757/ | 2008
Jean-Marie Péron; Jean-Michel Mansuy; Hélène Poirson; Christophe Bureau; Emmanuel Dupuis; Laurent Alric; Jacques Izopet; Jean-Pierre Vinel