Henrik Nienhüser
Heidelberg University
Network
Latest external collaboration on country level. Dive into details by clicking on the dots.
Publication
Featured researches published by Henrik Nienhüser.
Oncotarget | 2017
Susanne Blank; Henrik Nienhüser; Lena Dreikhausen; Leila Sisic; Ulrike Heger; Katja Ott; Thomas Schmidt
Background Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The tumor microenvironment and circulating factors as possible predictors of response and prognosis gain interest. This study aimed to investigate cytokines in patients’ serum and tumor tissue with regard to response and prognosis. Results Median survival between SCC and AC was not different (published previously). Lower levels of CCL11 (Eotaxin-1) and CXCL10 (IP-10) in the tumor tissue were associated with a better prognosis (p = 0.022; p = 0.002). In the AC subgroup higher concentrations of TGF-β3 in serum and corresponding tumor tissue were associated with adverse prognosis (p = 0.035; p = 0.006). An association with histopathological response was found for IL-12(p70) and CXCL10 in patients’ sera (p = 0.041; p = 0.032). The tissue levels of TGF-β1 and TGF-β2 were significantly lower in histopathological responders than in nonresponders (p = 0.033; p = 0.007). A similar trend was seen for TGF-β3, without statistical significance (p = 0.097). Materials and Methods Preoperative serum samples and corresponding tumor tissue (n = 54), only serum (n = 20) or only tissue (n = 4) were collected from patients undergoing surgery for cT3/4 esophageal squamous cell cancer (SCC) (n = 34) and adenocarcinoma (AC) (n = 44). All samples were taken after neoadjuvant treatment. All patients received perioperative chemo(radio)therapy. Cytokine levels of 17 different cytokines were measured by multiplex immunoassay and correlated with clinicopathological factors. Conclusions Two chemokines (CCL11 and CXCL10) in posttherapeutic tumor tissue were associated with prognosis in patients with esophageal cancer, lower levels indicating a better prognosis. Lower levels of TGF-β were associated with better response and prognosis in patients with AC.
International Journal of Molecular Sciences | 2017
Henrik Nienhüser; Thomas Schmidt
Gastric cancer is one of the most frequent malignancies worldwide. Despite improvements in diagnosis and therapy, the overall prognosis remains poor. In the last decade, several anti-angiogenic drugs for cancer treatment have been approved and lately also introduced to gastric cancer treatment. While the initial trials focused only on unresectable or metastatic cancer, anti-angiogenic treatment is now also investigated in the perioperative and neoadjuvant setting. In this review, an overview of the role of angiogenesis and angiogenic factors in gastric cancer as well as anti-angiogenic treatment of gastric cancer is provided. Findings from in vitro and animal studies are summarized and put in a context with translational data on angiogenesis in gastric cancer. The most important angiogenic factors and their effect in gastric cancer are highlighted and clinical trials including anti-angiogenic drugs are discussed. Finally, an outlook of biomarkers for predicting response to anti-angiogenic treatment is presented, the ongoing trials on this topic are discussed and current challenges of anti-angiogenic therapy are outlined.
Microarrays | 2016
Martin Sill; Christoph Schröder; Ying Shen; Aseel Marzoq; Radovan Komel; Jörg D. Hoheisel; Henrik Nienhüser; Thomas Schmidt; Damjana Kastelic
In this study, protein profiling was performed on gastric cancer tissue samples in order to identify proteins that could be utilized for an effective diagnosis of this highly heterogeneous disease and as targets for therapeutic approaches. To this end, 16 pairs of postoperative gastric adenocarcinomas and adjacent non-cancerous control tissues were analyzed on microarrays that contain 813 antibodies targeting 724 proteins. Only 17 proteins were found to be differentially regulated, with much fewer molecules than the numbers usually identified in studies comparing tumor to healthy control tissues. Insulin-like growth factor-binding protein 7 (IGFBP7), S100 calcium binding protein A9 (S100A9), interleukin-10 (IL‐10) and mucin 6 (MUC6) exhibited the most profound variations. For an evaluation of the proteins’ capacity for discriminating gastric cancer, a Receiver Operating Characteristic curve analysis was performed, yielding an accuracy (area under the curve) value of 89.2% for distinguishing tumor from non-tumorous tissue. For confirmation, immunohistological analyses were done on tissue slices prepared from another cohort of patients with gastric cancer. The utility of the 17 marker proteins, and particularly the four molecules with the highest specificity for gastric adenocarcinoma, is discussed for them to act as candidates for diagnosis, even in serum, and targets for therapeutic approaches.
Surgical Oncology-oxford | 2017
Leila Sisic; Susanne Blank; Henrik Nienhüser; Georg Martin Haag; Dirk Jäger; Tom Bruckner; Katja Ott; Thomas Schmidt; Alexis Ulrich
Lancet Oncology | 2018
Henrik Nienhüser; Thomas Schmidt
Journal of Gastrointestinal Surgery | 2018
Henrik Nienhüser; Patrick Heger; Robin Schmitz; Yakup Kulu; Markus K. Diener; Johannes Klose; Martin Schneider; Beat P. Müller-Stich; Alexis Ulrich; Markus W. Büchler; André L. Mihaljevic; Thomas Schmidt
Ejso | 2018
Thomas Schmidt; Henrik Nienhüser; Constantin Kuna; Johannes Klose; Moritz J. Strowitzki; Markus W. Büchler; Alexis Ulrich; Martin Schneider
Ejso | 2018
Leila Sisic; Susanne Blank; Henrik Nienhüser; Sara Dorr; Georg Martin Haag; Dirk Jäger; Thomas Bruckner; Beat P. Müller-Stich; Katja Ott; Markus W. Büchler; Alexis Ulrich; Thomas Schmidt
Annals of Surgical Oncology | 2018
Ulrike Heger; Leila Sisic; Henrik Nienhüser; Susanne Blank; Ulf Hinz; Georg Martin Haag; Katja Ott; Alexis Ulrich; Markus W. Büchler; Thomas Schmidt
Chirurg | 2017
Henrik Nienhüser; Susanne Blank; Leila Sisic; Romy Kunzmann; Ulrike Heger; K Ott; M.W. Büchler; Thomas Schmidt; Alexis Ulrich