Henrique Martins da Silveira

Primordial odontogenic tumour: clinicopathological analysis of six cases of a previously undescribed entity

To describe the clinicopathological and immuno‐histochemical features of six tumours that do not fulfil the criteria of any of the currently classified odontogenic tumours.

Evaluation of Mandibular Ramus Morphology Using Computed Tomography in Patients With Mandibular Prognathism and Retrognathia: Relevance to the Sagittal Split Ramus Osteotomy

PURPOSE The purpose of this study was to evaluate and compare the thickness of the mandibular ramus in patients with mandibular prognathism and retrognathia, as well as to assess the distribution of cancellous bone between the external and internal cortical plates above and posterior to the lingula. PATIENTS AND METHODS The mandibular ramus of 40 patients, of whom 20 had prognathism and 20 had retrognathia, were evaluated by use of high-resolution computed tomography scanning. RESULTS The mean thickness of the ramus in the prognathism group was 8.17 mm, which differed significantly from the mean value of 8.88 mm in those with retrognathia (P = .014). The mean vertical distance of the point of fusion between the cortical plates above the lingula was 8.95 mm for patients with prognathism and 9.41 mm for those with retrognathia, which was not a significant difference (P = .364). The mean horizontal distance of the point of fusion between the cortical plates posterior to the lingula was 8.32 mm for patients with prognathism and 9.74 mm for those with retrognathia, which was also not a significant difference (P = .066). CONCLUSIONS The mandibular ramus is thinner in patients with prognathism than in those with retrognathia. The distance of the point of fusion between the cortical plates above and posterior to the lingula is not influenced by the 2 types of mandibular deformity evaluated in this study. Computed tomography has proven to be a valuable tool to evaluate the morphology of the mandibular ramus.

Oral perineurioma: clinicopathologic features from two cases and review of literature

The present study reports two cases of oral perineuriomas, including a clinicopathologic review of the 39 published cases (17 intraneural and 22 extraneural perineuriomas) in the English language literature. In the first case, the tumor occurred in an 84-year-old male as a painless, asymptomatic, 20-mm submucosal nodule on the right lower mucobuccal fold near to the premolar area. In the second case, a 46-year-old female presented with a painless, 25-mm, slow-growing, fibrous, pedunculated nodule on the right buccal mucosa. In the first case, the tumor was composed of spindle cells arranged in a storiform pattern, classified as intraneural perineurioma; and in the second, it was an extraneural perineurioma, showing a whorled myxoid stroma. Immunohistochemical analysis confirmed the diagnosis by showing positivity for vimentin, EMA, and Glut-1 in case 1 and EMA, Glut-1, Claudin-1, and CD34 (focally) in case 2. Complete surgical removal was performed for both tumors, and there was no evidence of local recurrence after a long-term follow-up.

Denosumab-related osteonecrosis of the jaws: successful management with a conservative surgical approach

Denosumab-related osteonecrosis of the jaws (DRONJ) is a recently described entity that shares many common clinical and radiological features with bisphosphonate-related osteonecrosis of the jaws (BRONJ). The aim of the present study is to report a case of DRONJ affecting the anterior mandible of a 58-year-old male treated with denosumab to prevent skeletal-related events associated with prostate cancer. Conservative surgery in conjunction with antibiotic therapy and discontinuation of denosumab use were effective in managing the condition and the patient remains free of clinical and radiological changes after a 38 month follow-up.